Bucladesine - Pharmacology
Research News and Information

Saturday, March 20, 2010

Development of functional LH Receptors on pig cumulus-oocyte complexes cultured in vitro by a novel two-step culture system.

30 Jul 2009 We show in the present study that freshly isolated pig cumulus-oocyte complexes (COCs) display a limited response to LH, as assessed by the expression of hyaluronan synthase 2 (Has2) mRNA, activation of protein kinase A (PKA), production of ... Read more...

Salt-inducible kinase 1 in the rat pinealocyte: adrenergic regulation and role in arylalkylamine N-acetyltransferase gene transcription.

19 May 2009 The recognition of the basic leucine zipper domain in the regulation of transcriptional activity of cAMP response element-binding protein by salt-inducible kinase (SIK) prompted our investigation of the regulatory role of this kinase in the ... Read more...

The mechanism of the actions of oxaliplatin on ion currents and action potentials in differentiated NG108-15 neuronal cells.

3 May 2009 Oxaliplatin (OXAL) is a platinum-based chemotherapeutic agent which is effective against advanced or metastatic gastrointestinal cancer. However, the mechanisms responsible for the development of the neuropathy induced by this agent remain unclear. ... Read more...

Latest indexed articles for 'Bucladesine - Pharmacology'

These are the very latest articles for this heading:

• Development of functional LH Receptors on pig cumulus-oocyte complexes cultured in vitro by a novel two-step culture system. 30 Jul 2009
• Salt-inducible kinase 1 in the rat pinealocyte: adrenergic regulation and role in arylalkylamine N-acetyltransferase gene transcription. 19 May 2009
• The mechanism of the actions of oxaliplatin on ion currents and action potentials in differentiated NG108-15 neuronal cells. 3 May 2009
• Phosphorylation of myristoylated alanine-rich C kinase substrate is involved in the cAMP-dependent amylase release in parotid acinar cells. 14 Apr 2009
• The adenylyl cyclase-cAMP system suppresses TARC/CCL17 and MDC/CCL22 production through p38 MAPK and NF-kappaB in HaCaT keratinocytes. 14 Apr 2009
• Mechanisms of protein kinase C signaling in the modulation of 3',5'-cyclic adenosine monophosphate-mediated steroidogenesis in mouse gonadal cells. 10 Mar 2009
• Regulation of relaxin 3 gene expression via cAMP-PKA in a neuroblastoma cell line. 13 Feb 2009
• Induction of senescence by progesterone receptor-B activation in response to cAMP in ovarian cancer cells. 8 Feb 2009
• Selective up-regulation of GLT-1 in cultured astrocytes exposed to soluble mediators released by activated microglia. 5 Feb 2009
• Fatty acid 2-hydroxylase regulates cAMP-induced cell cycle exit in D6P2T schwannoma cells. 20 Jan 2009
• S100B Protein Regulates Astrocyte Shape and Migration via Interaction with Src Kinase: IMPLICATIONS FOR ASTROCYTE DEVELOPMENT, ACTIVATION, AND TUMOR GROWTH. 13 Jan 2009
• Serofendic acid promotes stellation induced by cAMP and cGMP analogs in cultured cortical astrocytes. 31 Dec 2008
• Effect of follicle size and dibutyryl cAMP on the cAMP content and gap junctional communication of porcine prepubertal cumulus-oocyte complexes during IVM. 30 Dec 2008
• Patterned growth and differentiation of human cord blood-derived neural stem cells on bio-functionalized surfaces. 30 Dec 2008
• Expression and in vitro regulation of pituitary adenylate cyclase-activating polypeptide (pacap38) and its type I receptor (pac1-r) in the gonads of tilapia (Oreochromis mossambicus). 21 Dec 2008
• Inhibitory effect of hypochlorous acid on lower esophageal sphincter tone relaxation by vasoactive intestinal peptide. 18 Dec 2008
• Effects of cholesterol and cAMP on progesterone production in cultured luteal cells isolated from pseudopregnant cat ovaries. 4 Dec 2008
• Induction of serum- and glucocorticoid-induced kinase-1 (SGK1) by cAMP regulates increases in alpha-ENaC. 29 Nov 2008
• Hydrogen sulfide evokes neurite outgrowth and expression of high-voltage-activated Ca2+ currents in NG108-15 cells: involvement of T-type Ca2+ channels. 26 Nov 2008
• Ectopic expression of angiopoietin-1 promotes neuronal differentiation in neural progenitor cells through the Akt pathway. 22 Nov 2008

See a longer list of these articles.

Technical information about 'Bucladesine'

Definition: A cyclic nucleotide derivative that mimics the action of endogenous CYCLIC AMP and is capable of permeating the cell membrane. It has vasodilator properties and is used as a cardiac stimulant. (From Merck Index, 11th ed)

Chemical name: Adenosine, N-(1-oxobutyl)-, cyclic 3',5'-(hydrogen phosphate) 2'-butanoate

Registry Number: 362-74-3

Descriptor UI: D003994

Alternative terms: Bucladesine; Dibutyryl Adenosine 3,5 Monophosphate; Dibutyryl Adenosine-3',5'-Monophosphate; Adenosine-3',5'-Monophosphate, Dibutyryl; Dibutyryl Adenosine 3',5' Monophosphate; N',O'-Dibutyryl-cAMP; N',O' Dibutyryl cAMP; N(6),0(2')-Dibutyryl Cyclic AMP; DBcAMP; (But)(2) cAMP; Dibutyryl Cyclic AMP; AMP, Dibutyryl Cyclic; Cyclic AMP, Dibutyryl; Bucladesine, Disodium Salt; Disodium Salt Bucladesine; Bucladesine, Sodium Salt; Sodium Salt Bucladesine; Bucladesine, Monosodium Salt; Monosodium Salt Bucladesine; Bucladesine, Barium (1:1) Salt;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Tree Number: D03.438.759.646.138.395.250; D13.695.462.200.250; D13.695.667.138.395.250; D13.695.827.068.395.250;

Online Note: use BUCLADESINE to search DIBUTYRYL CYCLIC AMP 1974-93

History Note: 94; was DIBUTYRYL CYCLIC AMP 1974-93

Technical Notes: DF: DIBU CYCL AMP