Butyric Acids - Pharmacology
Research News and Information

Sunday, November 22, 2009

Decursin inhibits retinal neovascularization via suppression of VEGFR-2 activation.

10 Sep 2009 PURPOSE: Pathologic angiogenesis in the retina leads to the catastrophic loss of vision. Retinopathy of prematurity (ROP), a vasoproliferative retinopathy, is a leading cause of blindness in children. We evaluated the inhibitory effect of decursin ... Read more...

Rabies virus glycoprotein expression in Drosophila S2 cells. I: design of expression/selection vectors, subpopulations selection and influence of sodium butyrate and culture medium on protein expression.

13 Jul 2009 The cDNA encoding the rabies virus glycoprotein (RVGP) gene was cloned in expression plasmids under the control of the inductive metallothionein promoter. They were designed in order to bear or not a secretion signal (i) and a cDNA coding for the ... Read more...

Studies on the pharmacokinetics and metabolism of a gamma-secretase inhibitor BMS-299897, and exploratory investigation of CYP enzyme induction.

29 Jun 2009 BMS-299897 is a gamma-secretase inhibitor that was effective in reducing amyloid beta-peptide (A beta) in transgenic mice and guinea pigs. Therefore, pharmacokinetic and drug metabolism studies were conducted in animals to support its clinical ... Read more...

Latest indexed articles for 'Butyric Acids - Pharmacology'

These are the very latest articles for this heading:

• Decursin inhibits retinal neovascularization via suppression of VEGFR-2 activation. 10 Sep 2009
• Rabies virus glycoprotein expression in Drosophila S2 cells. I: design of expression/selection vectors, subpopulations selection and influence of sodium butyrate and culture medium on protein expression. 13 Jul 2009
• Studies on the pharmacokinetics and metabolism of a gamma-secretase inhibitor BMS-299897, and exploratory investigation of CYP enzyme induction. 29 Jun 2009
• The analgesic effect of decursinol. 24 Jun 2009
• Structural and theoretical studies of [6-bromo-1-(4-fluorophenylmethyl)-4(1H)-quinolinon-3-yl)]-4-hydroxy-2-oxo-3-butenoïc acid as HIV-1 integrase inhibitor. 12 Jun 2009
• [Design and synthesis of peroxisome proliferator-activated receptor (PPAR) delta agonists and its implication to the driving force to elicit PPAR delta selectivity] 30 May 2009
• Peroxisome proliferator-activated receptor (PPAR)-gamma positively controls and PPARalpha negatively controls cyclooxygenase-2 expression in rat brain astrocytes through a convergence on PPARbeta/delta via mutual control of PPAR expression levels. 27 May 2009
• HDAC2 negatively regulates memory formation and synaptic plasticity. 5 May 2009
• Central administration of palmitoylethanolamide reduces hyperalgesia in mice via inhibition of NF-kappaB nuclear signalling in dorsal root ganglia. 18 Apr 2009
• Glutamine inhibits ammonia-induced accumulation of cGMP in rat striatum limiting arginine supply for NO synthesis. 16 Apr 2009
• Decursin and decursinol inhibit VEGF-induced angiogenesis by blocking the activation of extracellular signal-regulated kinase and c-Jun N-terminal kinase. Apr 2009
• Decursin and decursinol angelate inhibit VEGF-induced angiogenesis via suppression of the VEGFR-2-signaling pathway. 16 Feb 2009
• Direct regulation by the Vibrio cholerae regulator ToxT to modulate colonization and anticolonization pilus expression. 19 Jan 2009
• Lead acetate induces EGFR activation upstream of SFK and PKCalpha linkage to the Ras/Raf-1/ERK signaling. 22 Dec 2008
• In vitro inhibitory potential of decursin and decursinol angelate on the catalytic activity of cytochrome P-450 1A1/2, 2D15, and 3A12 isoforms in canine hepatic microsomes. 19 Nov 2008
• Rapid non-genomic regulation of Ca2+ signals and insulin secretion by PPAR alpha ligands in mouse pancreatic islets of Langerhans. 16 Nov 2008
• Androgen receptor functional analyses by high throughput imaging: determination of ligand, cell cycle, and mutation-specific effects. Nov 2008
• 15-deoxy-delta 12,14-prostaglandin J(2) inhibits the synthesis of the acute phase protein SIP24 in cartilage: Involvement of COX-2 in resolution of inflammation. 30 Oct 2008
• Thioredoxin-1 and its natural inhibitor, vitamin D3 up-regulated protein 1, are differentially regulated by PPARalpha in human macrophages. 30 Sep 2008
• Effects of isobutyrate on rumen fermentation, urinary excretion of purine derivatives and digestibility in steers. 29 Sep 2008

See a longer list of these articles.

Technical information about 'Butyric Acids'

Definition: 4-carbon acids, salts, and derivatives of BUTYRIC ACID.

Registry Number: 0

Descriptor UI: D002088

Alternative terms: Butyric Acids; Acids, Butyric; Butanoic Acids; Acids, Butanoic;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Tree Number: D02.241.081.160; D10.251.400.241;

History Note: 91(75); was see under BUTYRATES 1975-90

Technical Notes: BUTYRIC ACID is also available