Butyrylcholinesterase - Metabolism
Research News and Information

Monday, November 23, 2009

The structure of G117H mutant of butyrylcholinesterase: nerve agents scavenger.

30 Oct 2009 Organophosphate ester (OP) compounds are known for their ubiquitous use as insecticides. At the same time, these chemicals are highly toxic and can be used as nerve agents. G117H mutant of human Butyrylcholinesterase (BChE) was found to be capable ... Read more...

Pyrano[3,2-c]quinoline-6-chlorotacrine hybrids as a novel family of acetylcholinesterase- and beta-amyloid-directed anti-Alzheimer compounds.

8 Sep 2009 Two isomeric series of dual binding site acetylcholinesterase (AChE) inhibitors have been designed, synthesized, and tested for their ability to inhibit AChE, butyrylcholinesterase, AChE-induced and self-induced beta-amyloid (Abeta) aggregation, and ... Read more...

Novel 16-substituted bifunctional derivatives of huperzine B: multifunctional cholinesterase inhibitors.

4 Jul 2009 AIM: To design novel bifunctional derivatives of huperzine B (HupB) based on the concept of dual binding site of acetylcholinesterase (AChE) and evaluate their pharmacological activities for seeking new drug candidates against Alzheimer's disease ... Read more...

Latest indexed articles for 'Butyrylcholinesterase - Metabolism'

These are the very latest articles for this heading:

• The structure of G117H mutant of butyrylcholinesterase: nerve agents scavenger. 30 Oct 2009
• Pyrano[3,2-c]quinoline-6-chlorotacrine hybrids as a novel family of acetylcholinesterase- and beta-amyloid-directed anti-Alzheimer compounds. 8 Sep 2009
• CHI's Eighth Annual World Pharmaceutical Congress. Targeting Alzheimer's with novel therapeutics: Part 2. 30 Jul 2009
• Novel 16-substituted bifunctional derivatives of huperzine B: multifunctional cholinesterase inhibitors. 4 Jul 2009
• Adenovirus-transduced human butyrylcholinesterase in mouse blood functions as a bioscavenger of chemical warfare nerve agents. 17 Jun 2009
• Structure-activity analysis of aging and reactivation of human butyrylcholinesterase inhibited by analogues of tabun. 10 Jun 2009
• Post-exposure treatment with nasal atropine methyl bromide protects against microinstillation inhalation exposure to sarin in guinea pigs. 9 Jun 2009
• Enzymes cooperating in the hydrolyzing process of benzoylcholines: subcellular and inter-tissue comparison. 30 May 2009
• Synthesis of novel purine nucleosides towards a selective inhibition of human butyrylcholinesterase. 27 May 2009
• Lasting reduction of cocaine action in neostriatum--a hydrolase gene therapy approach. 26 May 2009
• No differences of butyrylcholinesterase protein activity and allele frequency in Lewy body diseases. 25 May 2009
• Synthesis of novel phosphorothioates and phosphorodithioates and their differential inhibition of cholinesterases. 13 May 2009
• Tacripyrines, the first tacrine-dihydropyridine hybrids, as multitarget-directed ligands for the treatment of Alzheimer's disease. 12 May 2009
• Heavy metal uranium affects the brain cholinergic system in rat following sub-chronic and chronic exposure. May 2009
• The butyrylcholinesterase knockout mouse a research tool in the study of drug sensitivity, bio-distribution, obesity and Alzheimer's disease. 29 Apr 2009
• Cholinesterase inhibitory effects of the extracts and compounds of Maclura pomifera (Rafin.) Schneider. 22 Apr 2009
• The butyrylcholinesterase K variant confers structurally derived risks for Alzheimer pathology. 19 Apr 2009
• QSAR studies on N-aryl derivative activity towards Alzheimer's disease. 5 Apr 2009
• Acetylcholinesterase and butyrylcholinesterase inhibition of ethanolic extract and monoterpenes from Pimpinella anisoides V Brig. (Apiaceae). 3 Apr 2009
• Esterase activities in the blood, liver and intestine of several preclinical species and humans. 30 Mar 2009

See a longer list of these articles.

Technical information about 'Butyrylcholinesterase'

Definition: An aspect of cholinesterase (EC 3.1.1.8).

Registry Number: EC 3.1.1.-

Descriptor UI: D002091

Alternative terms: Butyrylcholinesterase; Butyrylthiocholinesterase;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications;

Tree Number: D08.811.277.352.100.170.250;

History Note: 91(75); was see under CHOLINESTERASES 1975-90

Technical Notes: /antag = CHOLINESTERASE INHIBITORS (IM) + BUTYRYLCHOLINESTERASE (NIM with no qualif)