Butyrylcholinesterase
Research News and Information

Tuesday, November 24, 2009

The structure of G117H mutant of butyrylcholinesterase: nerve agents scavenger.

30 Oct 2009 Organophosphate ester (OP) compounds are known for their ubiquitous use as insecticides. At the same time, these chemicals are highly toxic and can be used as nerve agents. G117H mutant of human Butyrylcholinesterase (BChE) was found to be capable ... Read more...

Pyrano[3,2-c]quinoline-6-chlorotacrine hybrids as a novel family of acetylcholinesterase- and beta-amyloid-directed anti-Alzheimer compounds.

8 Sep 2009 Two isomeric series of dual binding site acetylcholinesterase (AChE) inhibitors have been designed, synthesized, and tested for their ability to inhibit AChE, butyrylcholinesterase, AChE-induced and self-induced beta-amyloid (Abeta) aggregation, and ... Read more...

An evaluation of the inhibition of human butyrylcholinesterase and acetylcholinesterase by the organophosphate chlorpyrifos oxon.

17 Aug 2009 Acetylcholinesterase (EC 3.1.1.7) and butyrylcholinesterase (EC 3.1.1.8) are enzymes that belong to the superfamily of alpha/beta-hydrolase fold proteins. While they share many characteristics, they also possess many important differences. For ... Read more...

Latest indexed articles for 'Butyrylcholinesterase'

These are the very latest articles for this heading:

• The structure of G117H mutant of butyrylcholinesterase: nerve agents scavenger. 30 Oct 2009
• Pyrano[3,2-c]quinoline-6-chlorotacrine hybrids as a novel family of acetylcholinesterase- and beta-amyloid-directed anti-Alzheimer compounds. 8 Sep 2009
• An evaluation of the inhibition of human butyrylcholinesterase and acetylcholinesterase by the organophosphate chlorpyrifos oxon. 17 Aug 2009
• CHI's Eighth Annual World Pharmaceutical Congress. Targeting Alzheimer's with novel therapeutics: Part 2. 30 Jul 2009
• Progression from mild cognitive impairment to Alzheimer's disease: effects of sex, butyrylcholinesterase genotype, and rivastigmine treatment. 30 Jul 2009
• Cholinesterase inhibitory activities of some flavonoid derivatives and chosen xanthone and their molecular docking studies. 7 Jul 2009
• Novel 16-substituted bifunctional derivatives of huperzine B: multifunctional cholinesterase inhibitors. 4 Jul 2009
• Adenovirus-transduced human butyrylcholinesterase in mouse blood functions as a bioscavenger of chemical warfare nerve agents. 17 Jun 2009
• Structure-activity analysis of aging and reactivation of human butyrylcholinesterase inhibited by analogues of tabun. 10 Jun 2009
• Post-exposure treatment with nasal atropine methyl bromide protects against microinstillation inhalation exposure to sarin in guinea pigs. 9 Jun 2009
• Serum cholinesterase inhibition in relation to paraoxonase-1 (PON1) status among organophosphate-exposed agricultural pesticide handlers. 7 Jun 2009
• Variability of AChE, BChE, and ChAT genes in the late-onset form of Alzheimer's disease and relationships with response to treatment with Donepezil and Rivastigmine. 3 Jun 2009
• Enzymes cooperating in the hydrolyzing process of benzoylcholines: subcellular and inter-tissue comparison. 30 May 2009
• Synthesis of novel purine nucleosides towards a selective inhibition of human butyrylcholinesterase. 27 May 2009
• Lasting reduction of cocaine action in neostriatum--a hydrolase gene therapy approach. 26 May 2009
• No differences of butyrylcholinesterase protein activity and allele frequency in Lewy body diseases. 25 May 2009
• Synthesis of novel phosphorothioates and phosphorodithioates and their differential inhibition of cholinesterases. 13 May 2009
• Tacripyrines, the first tacrine-dihydropyridine hybrids, as multitarget-directed ligands for the treatment of Alzheimer's disease. 12 May 2009
• Cholinesterase activity, pesticide exposure and health impact in a population exposed to organophosphates. 6 May 2009
• Model of human butyrylcholinesterase tetramer by homology modeling and dynamics simulation. 5 May 2009

See a longer list of these articles.

Technical information about 'Butyrylcholinesterase'

Definition: An aspect of cholinesterase (EC 3.1.1.8).

Registry Number: EC 3.1.1.-

Descriptor UI: D002091

Alternative terms: Butyrylcholinesterase; Butyrylthiocholinesterase;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications;

Tree Number: D08.811.277.352.100.170.250;

History Note: 91(75); was see under CHOLINESTERASES 1975-90

Technical Notes: /antag = CHOLINESTERASE INHIBITORS (IM) + BUTYRYLCHOLINESTERASE (NIM with no qualif)