Caffeic Acids - Pharmacology
Research News and Information

Sunday, November 22, 2009

Caffeic acid phenethyl ester, an active component of honeybee propolis attenuates osteoclastogenesis and bone resorption via the suppression of RANKL-induced NF-kappaB and NFAT activity.

29 Nov 2009 Receptor activator NF-kappaB ligand (RANKL)-activated signaling is essential for osteoclast differentiation, activation and survival. Caffeic acid phenethyl ester (CAPE), a natural NF-kappaB inhibitor from honeybee propolis has been shown to have ... Read more...

Anti-inflammatory effects of caffeic acid phenethyl ester (CAPE), a nuclear factor-kappaB inhibitor, on Helicobacter pylori-induced gastritis in Mongolian gerbils.

13 Oct 2009 Nuclear factor-kappaB (NF-kappaB) plays a major role in host inflammatory responses and carcinogenesis and as such is an important drug target for adjuvant therapy. In this study, we examined the effect of caffeic acid phenethyl ester (CAPE), an ... Read more...

Effect of salvianolic acid A on vascular reactivity of streptozotocin-induced diabetic rats.

15 Aug 2009 AIMS: The present study aims to evaluate the beneficial effect of salvianolic acid A (SAA) on the alterations in vascular reactivity of streptozotocin (STZ)-induced diabetic rats. MAIN METHODS: Diabetes was induced by a single intraperitoneal ... Read more...

Latest indexed articles for 'Caffeic Acids - Pharmacology'

These are the very latest articles for this heading:

• Caffeic acid phenethyl ester, an active component of honeybee propolis attenuates osteoclastogenesis and bone resorption via the suppression of RANKL-induced NF-kappaB and NFAT activity. 29 Nov 2009
• Anti-inflammatory effects of caffeic acid phenethyl ester (CAPE), a nuclear factor-kappaB inhibitor, on Helicobacter pylori-induced gastritis in Mongolian gerbils. 13 Oct 2009
• Effect of salvianolic acid A on vascular reactivity of streptozotocin-induced diabetic rats. 15 Aug 2009
• Evaluation of radioprotective effects of propolis and its flavonoid constituents: in vitro study on human white blood cells. 30 Jul 2009
• Caffeic acid phenethyl ester decreases cholangiocarcinoma growth by inhibition of NF-kappaB and induction of apoptosis. 30 Jul 2009
• Effect of caffeic acid and rofecoxib and their combination against intrastriatal quinolinic acid induced oxidative damage, mitochondrial and histological alterations in rats. 24 Jul 2009
• The effect of caffeic acid phenethyl ester on the functions of human monocyte-derived dendritic cells. 14 Jul 2009
• The protective effect of caffeic acid phenethyl ester (CAPE) on oxidative stress in rat liver exposed to the 900 MHz electromagnetic field. 29 Jun 2009
• Production of hydrogen peroxide is responsible for the induction of apoptosis by hydroxytyrosol on HL60 cells. 29 Jun 2009
• Dihydroxylated phenolic acids derived from microbial metabolism reduce lipopolysaccharide-stimulated cytokine secretion by human peripheral blood mononuclear cells. 29 Jun 2009
• Caffeic acid phenethyl ester decreases the level of S-100B protein after middle cerebral artery [correction for after] occlusion in rabbits. 29 Jun 2009
• Effects of Bidens pilosa L. var. radiata SCHERFF treated with enzyme on histamine-induced contraction of guinea pig ileum and on histamine release from mast cells. 30 May 2009
• Chemical constituents from the aerial parts of Artemisia minor. 30 May 2009
• Caffeic Acid inhibits colitis in a mouse model--is a drug-metabolizing gene crucial? 30 May 2009
• Protections of SMND-309, a novel derivate of salvianolic acid B, on brain mitochondria contribute to injury amelioration in cerebral ischemia rats. 26 May 2009
• Molecular modifications on carboxylic acid derivatives as potent histone deacetylase inhibitors: Activity and docking studies. 21 May 2009
• Anti-hepatitis B virus activity of chlorogenic acid, quinic acid and caffeic acid in vivo and in vitro. 18 May 2009
• Cardioprotective effect of salvianolic acid A on isoproterenol-induced myocardial infarction in rats. 11 May 2009
• Caffeic and chlorogenic acids in Ilex paraguariensis extracts are the main inhibitors of AGE generation by methylglyoxal in model proteins. 2 May 2009
• Caffeic acid phenethyl ester protects against tamoxifen-induced hepatotoxicity in rats. 22 Apr 2009

See a longer list of these articles.

Technical information about 'Caffeic Acids'

Definition: A class of phenolic acids related to chlorogenic acid, p-coumaric acid, vanillic acid, etc., which are found in plant tissues. It is involved in plant growth regulation.

Registry Number: 0

Descriptor UI: D002109

Alternative terms: Caffeic Acids; Acids, Caffeic;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Tree Number: D02.241.223.201.170;

History Note: 91(75); was see under CINNAMATES 1975-90