 |
Caffeine
Research News and Information
Definition of 'Caffeine'A methylxanthine naturally occurring in some beverages and also used as a pharmacological agent. Caffeine's most notable pharmacological effect is as a central nervous system stimulant, increasing alertness and producing agitation. It also relaxes SMOOTH MUSCLE, stimulates CARDIAC MUSCLE, stimulates DIURESIS, and appears to be useful in the treatment of some types of headache. Several cellular actions of caffeine have been observed, but it is not entirely clear how each contributes to its pharmacological profile. Among the most important are inhibition of cyclic nucleotide PHOSPHODIESTERASES, antagonism of ADENOSINE RECEPTORS, and modulation of intracellular calcium handling. |
Sunday, November 08, 2009
The role of CACNA1S in predisposition to malignant hyperthermia.
11 Oct 2009 
BACKGROUND: Malignant hyperthermia (MH) is an inherited pharmacogenetic disorder of skeletal muscle, characterised by an elevated calcium release from the skeletal muscle sarcoplasmic reticulum. The dihydropyridine receptor (DHPR) plays an essential ... Read more...
Centrosome abnormalities during porcine oocyte aging.
29 Sep 2009 Centrosomes are critically important for maintaining meiotic spindle integrity in the meiosis II (MII) stage where oocytes are arrested in most mammalian species before fertilization takes place. In women of advanced ages or during in vitro ... Read more...
Regulation of cerebrospinal fluid production by caffeine consumption.
Sep 2009 BACKGROUND: Caffeine is the most commonly consumed psycho-stimulant in the world. The effects of caffeine on the body have been extensively studied; however, its effect on the structure of the brain has not been investigated to date. RESULTS: In the ... Read more...
Latest indexed articles for 'Caffeine'
These are the very latest articles for this heading:
- The role of CACNA1S in predisposition to malignant hyperthermia. 11 Oct 2009
- Centrosome abnormalities during porcine oocyte aging. 29 Sep 2009
- Regulation of cerebrospinal fluid production by caffeine consumption. Sep 2009
- The effects of caffeine on sleep in Drosophila require PKA activity, but not the adenosine receptor. 31 Aug 2009
- Caffeine, artificial sweetener, and fluid intake in anorexia nervosa. 30 Aug 2009
- Caffeine expectancy: instrument development in the Rasch measurement framework. 30 Aug 2009
- Antineoplastic and cytogenetic effects of chlorpromazine on human lymphocytes in vitro and on Ehrlich ascites tumor cells in vivo. 30 Aug 2009
- Less Smad2 is good for you! A scientific update on coffee's liver benefits. 30 Aug 2009
- Ca2+- and thromboxane-dependent distribution of MaxiK channels in cultured astrocytes: from microtubules to the plasma membrane. 30 Aug 2009
- Panic disorder and social anxiety disorder subtypes in a caffeine challenge test. 18 Aug 2009
- Comparison of sarcoplasmic reticulum calcium content in atrial and ventricular myocytes of three fish species. 17 Aug 2009
- Caffeine consumption attenuates neurochemical modifications in the hippocampus of streptozotocin-induced diabetic rats. 16 Aug 2009
- [Physical activity and dietary supplements] 15 Aug 2009
- Variable luminal sarcoplasmic reticulum Ca(2+) buffer capacity in smooth muscle cells. 10 Aug 2009
- Relation between fractures and mortality: results from the Canadian Multicentre Osteoporosis Study. 2 Aug 2009
- Mountain Dew or mountain don't?: a pilot investigation of caffeine use parameters and relations to depression and anxiety symptoms in 5th- and 10th-grade students. 30 Jul 2009
- Effect of caffeine as an ergogenic aid during anaerobic exercise performance in caffeine naïve collegiate football players. 30 Jul 2009
- The effects of energy drinks alone and with alcohol on neuropsychological functioning. 30 Jul 2009
- Relationship of blood pressure, behavioral mood state, and physical activity following caffeine ingestion in younger and older women. 30 Jul 2009
- The effect of a carbohydrate-caffeine sports drink on simulated golf performance. 30 Jul 2009
See a longer list of these articles.
Technical information about 'Caffeine'
Definition: A methylxanthine naturally occurring in some beverages and also used as a pharmacological agent. Caffeine's most notable pharmacological effect is as a central nervous system stimulant, increasing alertness and producing agitation. It also relaxes SMOOTH MUSCLE, stimulates CARDIAC MUSCLE, stimulates DIURESIS, and appears to be useful in the treatment of some types of headache. Several cellular actions of caffeine have been observed, but it is not entirely clear how each contributes to its pharmacological profile. Among the most important are inhibition of cyclic nucleotide PHOSPHODIESTERASES, antagonism of ADENOSINE RECEPTORS, and modulation of intracellular calcium handling.
Chemical name: 1H-Purine-2,6-dione, 3,7-dihydro-1,3,7-trimethyl-
Registry Number: 58-08-2
Descriptor UI: D002110
Alternative terms: Caffeine; 1,3,7-Trimethylxanthine; Coffeinum N; Merck dura Brand of Caffeine; Coffeinum Purrum; Berlin-Chemie Brand of Caffeine; Dexitac; Republic Drug Brand of Caffeine; Vivarin; GlaxoSmithKline Brand of Caffeine; No Doz; Bristol-Myers Squibb Brand of Caffeine; Percoffedrinol N; Passauer Brand of Caffeine; Percutaféine; Pierre Fabre Brand of Caffeine; Quick-Pep; Thompson Brand 2 of Caffeine; Caffedrine; Thompson Brand 1 of Caffeine; Durvitan; Seid Brand of Caffeine;
Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;
Pharmacological Action: Phosphodiesterase Inhibitors; Central Nervous System Stimulants;
Tree Number: D03.132.960.175; D03.438.759.758.824.175;