Cannabidiol - Pharmacology
Research News and Information

Sunday, November 22, 2009

The putative cannabinoid receptor GPR55 affects osteoclast function in vitro and bone mass in vivo.

Sep 2009 GPR55 is a G protein-coupled receptor recently shown to be activated by certain cannabinoids and by lysophosphatidylinositol (LPI). However, the physiological role of GPR55 remains unknown. Given the recent finding that the cannabinoid receptors ... Read more...

Cannabidiol in medicine: a review of its therapeutic potential in CNS disorders.

29 Apr 2009 Cannabidiol (CBD) is the main non-psychotropic component of the glandular hairs of Cannabis sativa. It displays a plethora of actions including anticonvulsive, sedative, hypnotic, antipsychotic, antiinflammatory and neuroprotective properties. ... Read more...

Cannabidiol-2',6'-dimethyl ether, a cannabidiol derivative, is a highly potent and selective 15-lipoxygenase inhibitor.

28 Apr 2009 The inhibitory effect of nordihydroguaiaretic acid (NDGA) (a nonselective lipoxygenase (LOX) inhibitor)-mediated 15-LOX inhibition has been reported to be affected by modification of its catechol ring, such as methylation of the hydroxyl group. ... Read more...

Latest indexed articles for 'Cannabidiol - Pharmacology'

These are the very latest articles for this heading:

• The putative cannabinoid receptor GPR55 affects osteoclast function in vitro and bone mass in vivo. Sep 2009
• Cannabidiol in medicine: a review of its therapeutic potential in CNS disorders. 29 Apr 2009
• Cannabidiol-2',6'-dimethyl ether, a cannabidiol derivative, is a highly potent and selective 15-lipoxygenase inhibitor. 28 Apr 2009
• Cannabidiol reverses the reduction in social interaction produced by low dose Delta(9)-tetrahydrocannabinol in rats. 21 Apr 2009
• Modulation of mediotemporal and ventrostriatal function in humans by Delta9-tetrahydrocannabinol: a neural basis for the effects of Cannabis sativa on learning and psychosis. 30 Mar 2009
• Time-dependent vascular actions of cannabidiol in the rat aorta. 9 Mar 2009
• Cannabidiol targets mitochondria to regulate intracellular Ca2+ levels. 16 Feb 2009
• Psychomotor performance in relation to acute oral administration of Delta9-tetrahydrocannabinol and standardized cannabis extract in healthy human subjects. 15 Feb 2009
• The nonpsychotropic cannabinoid cannabidiol modulates and directly activates alpha-1 and alpha-1-Beta glycine receptor function. 8 Feb 2009
• Delta9-tetrahydrocannabinol and cannabidiol modulate mitogen-induced tryptophan degradation and neopterin formation in peripheral blood mononuclear cells in vitro. 20 Jan 2009
• 5-HT1A receptors are involved in the cannabidiol-induced attenuation of behavioural and cardiovascular responses to acute restraint stress in rats. 30 Dec 2008
• Cannabidiol: a promising drug for neurodegenerative disorders? 30 Dec 2008
• Distinct effects of {delta}9-tetrahydrocannabinol and cannabidiol on neural activation during emotional processing. 30 Dec 2008
• Cannabidiol attenuates cisplatin-induced nephrotoxicity by decreasing oxidative/nitrosative stress, inflammation, and cell death. 10 Dec 2008
• Neuroprotective effects of cannabidiol in endotoxin-induced uveitis: critical role of p38 MAPK activation. Dec 2008
• Antiaversive effects of cannabinoids: is the periaqueductal gray involved? 30 Nov 2008
• The nonpsychoactive Cannabis constituent cannabidiol is a wake-inducing agent. 29 Nov 2008
• Neuroprotective effects of the nonpsychoactive cannabinoid cannabidiol in hypoxic-ischemic newborn piglets. 29 Nov 2008
• Facilitation of contextual fear memory extinction and anti-anxiogenic effects of AM404 and cannabidiol in conditioned rats. 13 Aug 2008
• The effects of cannabidiol and tetrahydrocannabinol on motion-induced emesis in Suncus murinus. 30 Jul 2008

See a longer list of these articles.

Technical information about 'Cannabidiol'

Definition: Compound isolated from Cannabis sativa extract.

Chemical name: 1,3-Benzenediol, 2-(3-methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl)-5-pentyl-, (1R-trans)-

Registry Number: 13956-29-1

Descriptor UI: D002185

Alternative terms: Cannabidiol;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Tree Number: D02.455.849.090.100;

History Note: 91(75); was see under CANNABINOIDS 1977-90; was see under CANNABIS 1975-76