Cannabidiol
Research News and Information

Monday, November 23, 2009

The putative cannabinoid receptor GPR55 affects osteoclast function in vitro and bone mass in vivo.

Sep 2009 GPR55 is a G protein-coupled receptor recently shown to be activated by certain cannabinoids and by lysophosphatidylinositol (LPI). However, the physiological role of GPR55 remains unknown. Given the recent finding that the cannabinoid receptors ... Read more...

High pressure Diels-Alder approach to hydroxy-substituted 6a-cyano-tetrahydro-6H-benzo[c]chromen-6-ones: a route to delta(6)-cis-cannabidiol.

3 Jun 2009 Diels-Alder cycloaddition reactions of 3-cyanocoumarin, hydroxy-substituted 3-cyanocoumarins and mesyl-substituted 3-cyano-coumarins with methyl-1,3-butadienes carried out under high pressure (11 kbar) are reported. Activation by high pressure ... Read more...

Cannabidiol in medicine: a review of its therapeutic potential in CNS disorders.

29 Apr 2009 Cannabidiol (CBD) is the main non-psychotropic component of the glandular hairs of Cannabis sativa. It displays a plethora of actions including anticonvulsive, sedative, hypnotic, antipsychotic, antiinflammatory and neuroprotective properties. ... Read more...

Latest indexed articles for 'Cannabidiol'

These are the very latest articles for this heading:

• The putative cannabinoid receptor GPR55 affects osteoclast function in vitro and bone mass in vivo. Sep 2009
• High pressure Diels-Alder approach to hydroxy-substituted 6a-cyano-tetrahydro-6H-benzo[c]chromen-6-ones: a route to delta(6)-cis-cannabidiol. 3 Jun 2009
• Cannabidiol in medicine: a review of its therapeutic potential in CNS disorders. 29 Apr 2009
• Cannabidiol-2',6'-dimethyl ether, a cannabidiol derivative, is a highly potent and selective 15-lipoxygenase inhibitor. 28 Apr 2009
• Cannabidiol reverses the reduction in social interaction produced by low dose Delta(9)-tetrahydrocannabinol in rats. 21 Apr 2009
• Modulation of mediotemporal and ventrostriatal function in humans by Delta9-tetrahydrocannabinol: a neural basis for the effects of Cannabis sativa on learning and psychosis. 30 Mar 2009
• Evaluation of principal cannabinoids in airborne particulates. 29 Mar 2009
• Time-dependent vascular actions of cannabidiol in the rat aorta. 9 Mar 2009
• Cannabidiol targets mitochondria to regulate intracellular Ca2+ levels. 16 Feb 2009
• Psychomotor performance in relation to acute oral administration of Delta9-tetrahydrocannabinol and standardized cannabis extract in healthy human subjects. 15 Feb 2009
• The nonpsychotropic cannabinoid cannabidiol modulates and directly activates alpha-1 and alpha-1-Beta glycine receptor function. 8 Feb 2009
• Delta9-tetrahydrocannabinol and cannabidiol modulate mitogen-induced tryptophan degradation and neopterin formation in peripheral blood mononuclear cells in vitro. 20 Jan 2009
• Psychopathological and cognitive effects of therapeutic cannabinoids in multiple sclerosis: a double-blind, placebo controlled, crossover study. 30 Dec 2008
• 5-HT1A receptors are involved in the cannabidiol-induced attenuation of behavioural and cardiovascular responses to acute restraint stress in rats. 30 Dec 2008
• Cannabidiol: a promising drug for neurodegenerative disorders? 30 Dec 2008
• Distinct effects of {delta}9-tetrahydrocannabinol and cannabidiol on neural activation during emotional processing. 30 Dec 2008
• Cannabidiol attenuates cisplatin-induced nephrotoxicity by decreasing oxidative/nitrosative stress, inflammation, and cell death. 10 Dec 2008
• Cannabidiol decreases bone resorption by inhibiting RANK/RANKL expression and pro-inflammatory cytokines during experimental periodontitis in rats. 10 Dec 2008
• Neuroprotective effects of cannabidiol in endotoxin-induced uveitis: critical role of p38 MAPK activation. Dec 2008
• Antiaversive effects of cannabinoids: is the periaqueductal gray involved? 30 Nov 2008

See a longer list of these articles.

Technical information about 'Cannabidiol'

Definition: Compound isolated from Cannabis sativa extract.

Chemical name: 1,3-Benzenediol, 2-(3-methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl)-5-pentyl-, (1R-trans)-

Registry Number: 13956-29-1

Descriptor UI: D002185

Alternative terms: Cannabidiol;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Tree Number: D02.455.849.090.100;

History Note: 91(75); was see under CANNABINOIDS 1977-90; was see under CANNABIS 1975-76