Captopril
Research News and Information

Sunday, November 22, 2009

Long-term stability of extemporaneously prepared captopril oral liquids in glass bottles.

29 Sep 2009 PURPOSE: The long-term stability of captopril in extemporaneously prepared oral liquids was studied. METHODS: Captopril solutions of 1 and 5 mg/mL were prepared in sterile water for irrigation with sorbitol, disodium edetate, and sodium benzoate. ... Read more...

Polymer-mesoporous silica materials templated with an oppositely charged surfactant/polymer system for drug delivery.

30 Aug 2009 In this paper, polymer-mesoporous silica nanoparticles have been synthesized by a dual-template technology. Cationic polymer quaternized poly[bis(2-chloroethyl)ether-alt-1,3-bis[3-(dimethylamino)propyl]urea] (PEPU) and anionic surfactant sodium ... Read more...

Effects of microinjection of angiotensin II and captopril to VTA on morphine self-administration in rats.

30 Aug 2009 The dopaminergic mesolimbic system is considered to be crucial in rewarding actions of opiates. Recent studies have suggested probable interaction between the renin-angiotensin and mesolimbic dopaminergic systems. The present study was undertaken to ... Read more...

Latest indexed articles for 'Captopril'

These are the very latest articles for this heading:

• Long-term stability of extemporaneously prepared captopril oral liquids in glass bottles. 29 Sep 2009
• Polymer-mesoporous silica materials templated with an oppositely charged surfactant/polymer system for drug delivery. 30 Aug 2009
• Effects of microinjection of angiotensin II and captopril to VTA on morphine self-administration in rats. 30 Aug 2009
• The effect of angiotensin-converting enzyme inhibitor on hemodynamic instability in patients undergoing cardiopulmonary bypass: results of a dose-comparison study. 30 Aug 2009
• Acquisition of the contractile phenotype by murine arterial smooth muscle cells depends on the Mir143/145 gene cluster. 15 Aug 2009
• Effect of melatonin, captopril, spironolactone and simvastatin on blood pressure and left ventricular remodelling in spontaneously hypertensive rats. 30 Jul 2009
• Comparison of the effects of indapamide and captopril on the development of spontaneous hypertension. 30 Jul 2009
• Combinational chelation therapy abrogates lead-induced neurodegeneration in rats. 8 Jul 2009
• Synergistic decrease in blood pressure by captopril combined with losartan in spontaneous hypertensive rats. 24 Jun 2009
• The effect of angiotensin-converting enzyme inhibition using captopril on energy balance and glucose homeostasis. 2 Jun 2009
• Usefulness of beta blockers in high-risk patients after myocardial infarction in conjunction with captopril and/or valsartan (from the VALsartan In Acute Myocardial Infarction [VALIANT] trial). Jun 2009
• Advantages of standardized criteria for the interpretation of angiotensin-converting enzyme inhibition renography. 30 May 2009
• Ethyl-propiolate as a novel and promising analytical reagent for the derivatization of thiols: study of the reaction under flow conditions. 26 May 2009
• Angiotensin-converting enzyme inhibition and angiotensin AT(1)-receptor antagonism equally improve doxorubicin-induced cardiotoxicity and nephrotoxicity. 21 May 2009
• Angiotensin converting enzyme inhibition lowers body weight and improves glucose tolerance in C57BL/6J mice maintained on a high fat diet. 20 May 2009
• Primary aldosteronism: diagnostic accuracy of the losartan and captopril tests. 12 May 2009
• ACE inhibition and protection from doxorubicin-induced cardiotoxicity in the rat. 29 Apr 2009
• Effect of sodium houttuyfonate on myocardial hypertrophy in mice and rats. 29 Apr 2009
• Effects of microinjection of angiotensin II and captopril into nucleus accumbens on morphine self-administration in rats. 29 Apr 2009
• Rapid analysis of captopril in human plasma and pharmaceutical preparations by headspace solid phase microextraction based on polypyrrole film coupled to ion mobility spectrometry. 14 Apr 2009

See a longer list of these articles.

Technical information about 'Captopril'

Definition: A potent and specific inhibitor of PEPTIDYL-DIPEPTIDASE A. It blocks the conversion of ANGIOTENSIN I to ANGIOTENSIN II, a vasoconstrictor and important regulator of arterial blood pressure. Captopril acts to suppress the RENIN-ANGIOTENSIN SYSTEM and inhibits pressure responses to exogenous angiotensin.

Chemical name: L-Proline, 1-(3-mercapto-2-methyl-1-oxopropyl)-, (S)-

Registry Number: 62571-86-2

Descriptor UI: D002216

Alternative terms: Captopril; (S)-1-(3-Mercapto-2-methyl-1-oxopropyl)-L-proline; SQ-14,534; SQ 14,534; SQ14,534; SQ-14534; SQ 14534; SQ14534; SQ-14,225; SQ 14,225; SQ14,225; SQ-14225; SQ 14225; SQ14225; Capoten; Lopirin;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents;

Tree Number: D12.125.072.401.623.270;

Online Note: use CAPTOPRIL to search SQ 14225 1980-93

History Note: 86(80); was see under PROLINE 1980-85; SQ 14225 was see CAPTOPRIL 1980-93