Carbachol - Pharmacology
Research News and Information

Sunday, November 22, 2009

Negative regulation of endogenous protein kinase Calpha on the dynamic change of carbachol-induced intracellular calcium response in different melanoma cells.

30 Oct 2009 Regulations of intracellular protein kinase C (PKC) on carbachol (CCh)-induced intracellular calcium ([Ca(2+)]i) responses were investigated in different stages of melanoma cells. We found that CCh (1 mM) significantly increased [Ca(2+)]i with 6-, ... Read more...

Inbred mouse strains differ in multiple hippocampal activity traits.

2 Sep 2009 A major challenge in neuroscience is to identify genes that influence specific behaviors and to understand the intermediary neuronal mechanisms. One approach is to identify so-called endophenotypes at different levels of neuronal organization from ... Read more...

Cholinergic modulation of GABAergic and glutamatergic transmission in the dorsal subcoeruleus: mechanisms for REM sleep control.

30 Aug 2009 STUDY OBJECTIVES: Dorsal subcoeruleus (SubCD) neurons are thought to promote PGO waves and to be modulated by cholinergic afferents during REM sleep. We examined the differential effect of the cholinergic agonist carbachol (CAR) on excitatory and ... Read more...

Latest indexed articles for 'Carbachol - Pharmacology'

These are the very latest articles for this heading:

• Negative regulation of endogenous protein kinase Calpha on the dynamic change of carbachol-induced intracellular calcium response in different melanoma cells. 30 Oct 2009
• Inbred mouse strains differ in multiple hippocampal activity traits. 2 Sep 2009
• Cholinergic modulation of GABAergic and glutamatergic transmission in the dorsal subcoeruleus: mechanisms for REM sleep control. 30 Aug 2009
• Regulation of neuronal activities within REM sleep-sign generators. 30 Aug 2009
• Targets, receptors and effects of muscarinic neuromodulation on giant neurones of the rat dorsal cochlear nucleus. 25 Aug 2009
• Effects of Chinese herbs on salivary fluid secretion by isolated and perfused rat submandibular glands. 19 Aug 2009
• Variable luminal sarcoplasmic reticulum Ca(2+) buffer capacity in smooth muscle cells. 10 Aug 2009
• Synchronization of pancreatic islet oscillations by intrapancreatic ganglia: a modeling study. 3 Aug 2009
• M1 receptors mediate cholinergic modulation of excitability in neocortical pyramidal neurons. 3 Aug 2009
• Boosting cholinergic activity in gustatory cortex enhances the salience of a familiar conditioned stimulus in taste aversion learning. 30 Jul 2009
• A novel fluorescent alpha-conotoxin for the study of alpha7 nicotinic acetylcholine receptors. 21 Jul 2009
• Deletion of TRPC3 in mice reduces store-operated Ca2+ influx and the severity of acute pancreatitis. 17 Jul 2009
• Carbachol induces p70S6K1 activation through an ERK-dependent but Akt-independent pathway in human colonic epithelial cells. 14 Jul 2009
• Defects in muscarinic receptor cell signaling in bladder urothelial cancer cell lines. 30 Jun 2009
• Carbachol induces Ca(2+)-dependent contraction via muscarinic M2 and M3 receptors in rat intestinal subepithelial myofibroblasts. 29 Jun 2009
• [The significance of extracellular Ca2+ in contractile responses in chick amnion] 29 Jun 2009
• Expression of muscarinic receptors in human and mouse sclera and their role in the regulation of scleral fibroblasts proliferation. 28 Jun 2009
• Deletion of TRPC4 and TRPC6 in mice impairs smooth muscle contraction and intestinal motility in vivo. 19 Jun 2009
• Loss of M2 muscarinic receptor function inhibits development of hypoxic bradycardia and alters cardiac beta-adrenergic sensitivity in larval zebrafish (Danio rerio). 8 Jun 2009
• In vitro and in vivo characterization of opioid activities of C-terminal esterified endomorphin-2 analogs. 7 Jun 2009

See a longer list of these articles.

Technical information about 'Carbachol'

Definition: A slowly hydrolyzed cholinergic agonist that acts at both muscarinic and nicotinic receptors.

Chemical name: Ethanaminium, 2-((aminocarbonyl)oxy)-N,N,N-trimethyl-, chloride

Registry Number: 51-83-2

Descriptor UI: D002217

Alternative terms: Carbachol; NutraMax Brand of Carbachol; Carbocholine; Bioniche Brand of Carbachol; Carbacholine; Carboptic; Optopics Brand of Carbachol; Doryl; Merck Brand of Carbachol; Isopto Carbachol; Carbachol, Isopto; Allphar Brand of Carbachol; Bipharma Brand of Carbachol; Alcon Brand 1 of Carbachol; Jestryl; Chauvin Brand of Carbachol; Carbamann; Mann Brand of Carbachol; Carbamylcholine; Carbamoylcholine; Carbastat; Novartis Brand of Carbachol; Miostat; Alcon Brand 2 of Carbachol;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: Cardiotonic Agents; Miotics; Cholinergic Agonists; Analgesics, Non-Narcotic;

Tree Number: D02.092.877.883.333.115; D02.675.276.232.115;