Carbolines - Pharmacology
Research News and Information

Saturday, November 21, 2009

Phosphodiesterase-5 inhibitor, tadalafil, protects against myocardial ischemia/reperfusion through protein-kinase g-dependent generation of hydrogen sulfide.

13 Sep 2009 BACKGROUND: Tadalafil is a novel long-acting inhibitor of phosphodiesterase-5. Because cGMP-dependent protein kinase (PKG) signaling plays a key role in cardioprotection, we hypothesized that PKG activation with tadalafil would limit myocardial ... Read more...

Tobacco mosaic virus (TMV) inhibitors from Picrasma quassioides Benn.

10 Aug 2009 To investigate natural inhibitors against tobacco mosaic virus (TMV) from plants, 10 known beta-carboline alkaloids and one quassinoid have been isolated from MeOH extract of the wood of Picrasma quassioides Benn. These compounds were screened for ... Read more...

Interactions between cyclic nucleotide phosphodiesterase 11 catalytic site and substrates or tadalafil and role of a critical Gln-869 hydrogen bond.

27 Jul 2009 Poor understanding of the topography of cyclic nucleotide (CN) phosphodiesterase (PDE) catalytic sites compromises development of potent, selective inhibitors for therapeutic use. In the X-ray crystal structures of the catalytic domains of some ... Read more...

Latest indexed articles for 'Carbolines - Pharmacology'

These are the very latest articles for this heading:

• Phosphodiesterase-5 inhibitor, tadalafil, protects against myocardial ischemia/reperfusion through protein-kinase g-dependent generation of hydrogen sulfide. 13 Sep 2009
• Tobacco mosaic virus (TMV) inhibitors from Picrasma quassioides Benn. 10 Aug 2009
• Interactions between cyclic nucleotide phosphodiesterase 11 catalytic site and substrates or tadalafil and role of a critical Gln-869 hydrogen bond. 27 Jul 2009
• Effect of tadalafil on renal resistivity and pulsatility index in partial ureteral obstruction. 25 Jul 2009
• Nitric oxide inhibits IFN regulatory factor 1 and nuclear factor-kappaB pathways in rhinovirus-infected epithelial cells. 7 Jul 2009
• Molecular determinants of beta-carboline inhibition of the glycine receptor. 6 Jul 2009
• Metaplasticity of hypothalamic synapses following in vivo challenge. 23 Jun 2009
• Pharmacological characterization of harmaline-induced tremor activity in mice. 31 May 2009
• Expression of renewal is dependent on the extinction-test interval rather than the acquisition-extinction interval. 30 May 2009
• Tabernines A-C, beta-carbolines from the leaves of Tabernaemontana elegans. 30 May 2009
• Novel N-(3-carboxyl-9-benzyl-beta-carboline-1-yl)ethylamino acids: synthesis, anti-tumor evaluation, intercalating determination, 3D QSAR analysis and docking investigation. 19 May 2009
• Synthesis of hybrid analogues of caffeine and eudistomin D and its affinity for adenosine receptors. 16 May 2009
• NAADP receptors mediate calcium signaling stimulated by endothelin-1 and norepinephrine in renal afferent arterioles. 11 May 2009
• Long-acting phosphodiesterase-5 inhibitor, tadalafil, induces sustained cardioprotection against lethal ischemic injury. 6 May 2009
• Synthesis and biological evaluation of novel gamma-carboline analogues of Dimebon as potent 5-HT6 receptor antagonists. May 2009
• Antiplatelet activity of beta-carboline alkaloids from Perganum harmala: a possible mechanism through inhibiting PLCgamma2 phosphorylation. 29 Apr 2009
• Comparative relaxing effects of sildenafil, vardenafil, and tadalafil in human corpus cavernosum: contribution of endogenous nitric oxide release. 13 Apr 2009
• The impact of NAT2 acetylator genotype on mutagenesis and DNA adducts from 2-amino-9H-pyrido[2,3-b]indole. 30 Mar 2009
• Renewal and spontaneous recovery, but not latent inhibition, are mediated by gamma-aminobutyric acid in appetitive conditioning. 30 Mar 2009
• 5-Bromo-8-methoxy-1-methyl-beta-carboline, an alkaloid from the New Zealand marine bryozoan Pterocella vesiculosa. 30 Mar 2009

See a longer list of these articles.

Technical information about 'Carbolines'

Definition: A group of pyrido-indole compounds. Included are any points of fusion of pyridine with the five-membered ring of indole and any derivatives of these compounds. These are similar to CARBAZOLES which are benzo-indoles.

Chemical name: Pyrido(4,3-b)Indoles

Registry Number: 0

Descriptor UI: D002243

Alternative terms: Carbolines; Pyrido(4,3-b)Indoles; Beta-Carbolines; Beta Carbolines;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Tree Number: D03.383.725.150; D03.438.473.155; D03.494.154;

History Note: 86(75); was see under INDOLES 1975-85