Carbolines
Research News and Information

Sunday, November 22, 2009

Phosphodiesterase-5 inhibitor, tadalafil, protects against myocardial ischemia/reperfusion through protein-kinase g-dependent generation of hydrogen sulfide.

13 Sep 2009 BACKGROUND: Tadalafil is a novel long-acting inhibitor of phosphodiesterase-5. Because cGMP-dependent protein kinase (PKG) signaling plays a key role in cardioprotection, we hypothesized that PKG activation with tadalafil would limit myocardial ... Read more...

Tobacco mosaic virus (TMV) inhibitors from Picrasma quassioides Benn.

10 Aug 2009 To investigate natural inhibitors against tobacco mosaic virus (TMV) from plants, 10 known beta-carboline alkaloids and one quassinoid have been isolated from MeOH extract of the wood of Picrasma quassioides Benn. These compounds were screened for ... Read more...

Sudden hearing loss from PDE-5 inhibitors: A possible cellular stress etiology.

30 Jul 2009 OBJECTIVES: Phosphodiesterase-5 (PDE) inhibitors are a relatively new class of drugs introduced in 1998 for the treatment of erectile dysfunction and pulmonary artery hypertension. Recent concerns regarding these drugs and sudden sensorineural ... Read more...

Latest indexed articles for 'Carbolines'

These are the very latest articles for this heading:

• Phosphodiesterase-5 inhibitor, tadalafil, protects against myocardial ischemia/reperfusion through protein-kinase g-dependent generation of hydrogen sulfide. 13 Sep 2009
• Penile rehabilitation. 30 Aug 2009
• Tobacco mosaic virus (TMV) inhibitors from Picrasma quassioides Benn. 10 Aug 2009
• Sudden hearing loss from PDE-5 inhibitors: A possible cellular stress etiology. 30 Jul 2009
• Interactions between cyclic nucleotide phosphodiesterase 11 catalytic site and substrates or tadalafil and role of a critical Gln-869 hydrogen bond. 27 Jul 2009
• Effect of tadalafil on renal resistivity and pulsatility index in partial ureteral obstruction. 25 Jul 2009
• Nitric oxide inhibits IFN regulatory factor 1 and nuclear factor-kappaB pathways in rhinovirus-infected epithelial cells. 7 Jul 2009
• Molecular determinants of beta-carboline inhibition of the glycine receptor. 6 Jul 2009
• Inhibitory effect of magnolol on Trp-P-2-induced DNA damage in various organs in mice. 29 Jun 2009
• Metaplasticity of hypothalamic synapses following in vivo challenge. 23 Jun 2009
• Improvements in confidence, sexual relationship and satisfaction measures: results of a randomized trial of tadalafil 5 mg taken once daily. 16 Jun 2009
• One- and two-photon excitation of beta-carbolines in aqueous solution: pH-dependent spectroscopy, photochemistry, and photophysics. 16 Jun 2009
• Dexamethasone but not tadalafil improves exercise capacity in adults prone to high-altitude pulmonary edema. 9 Jun 2009
• [Once daily therapy of erectile dysfunction. "Flexible love life without time constraints"] 2 Jun 2009
• Pharmacological characterization of harmaline-induced tremor activity in mice. 31 May 2009
• [Safety and tolerance of tadalafil in the treatment of erectile dysfunction] 30 May 2009
• DMD mediated formal synthesis of (+/-)-coerulescine. 30 May 2009
• Expression of renewal is dependent on the extinction-test interval rather than the acquisition-extinction interval. 30 May 2009
• Tabernines A-C, beta-carbolines from the leaves of Tabernaemontana elegans. 30 May 2009
• High performance liquid chromatography-diode array and electrospray-mass spectrometry analysis of vardenafil, sildenafil, tadalafil, testosterone and local anesthetics in cosmetic creams sold on the Internet web sites. 28 May 2009

See a longer list of these articles.

Technical information about 'Carbolines'

Definition: A group of pyrido-indole compounds. Included are any points of fusion of pyridine with the five-membered ring of indole and any derivatives of these compounds. These are similar to CARBAZOLES which are benzo-indoles.

Chemical name: Pyrido(4,3-b)Indoles

Registry Number: 0

Descriptor UI: D002243

Alternative terms: Carbolines; Pyrido(4,3-b)Indoles; Beta-Carbolines; Beta Carbolines;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Tree Number: D03.383.725.150; D03.438.473.155; D03.494.154;

History Note: 86(75); was see under INDOLES 1975-85