Carbon Radioisotopes
Research News and Information

Sunday, November 22, 2009

Ex vivo [11C]-(+)-PHNO binding is unchanged in animal models displaying increased high-affinity states of the D2 receptor in vitro.

30 Oct 2009 Dopamine (DA) D2 receptor supersensitivity has been linked to an increase in the density of the D2 high-affinity state as measured in vitro. The two- affinity-state model of the D2 receptor predicts that the ex vivo specific binding of ... Read more...

Evaluation of N-benzyl-N-[11C]methyl-2- (7-methyl-8-oxo-2-phenyl-7,8-dihydro-9H-purin-9-yl)acetamide ([11C]DAC) as a novel translocator protein (18 kDa) radioligand in kainic acid-lesioned rat.

30 Oct 2009 The aim of this study was to evaluate N-benzyl-N-[11C]methyl-2-(7-methyl-8-oxo-2-phenyl-7,8-dihydro-9H-purin-9-yl)acetamide ([11C]DAC) as a new translocator protein (18 kDa) [TSPO, formerly known as the peripheral-type benzodiazepine receptor (PBR)] ... Read more...

Synthesis and small-animal positron emission tomography evaluation of [11C]-elacridar as a radiotracer to assess the distribution of P-glycoprotein at the blood-brain barrier.

6 Oct 2009 With the aim to develop a positron emission tomography (PET) tracer to assess the distribution of P-glycoprotein (P-gp) at the blood-brain barrier (BBB) in vivo, the potent third-generation P-gp inhibitor elacridar (1) was labeled with (11)C by ... Read more...

Latest indexed articles for 'Carbon Radioisotopes'

These are the very latest articles for this heading:

• Ex vivo [11C]-(+)-PHNO binding is unchanged in animal models displaying increased high-affinity states of the D2 receptor in vitro. 30 Oct 2009
• Evaluation of N-benzyl-N-[11C]methyl-2- (7-methyl-8-oxo-2-phenyl-7,8-dihydro-9H-purin-9-yl)acetamide ([11C]DAC) as a novel translocator protein (18 kDa) radioligand in kainic acid-lesioned rat. 30 Oct 2009
• Synthesis and small-animal positron emission tomography evaluation of [11C]-elacridar as a radiotracer to assess the distribution of P-glycoprotein at the blood-brain barrier. 6 Oct 2009
• Possible freshwater resource consumption by the earliest directly dated European modern humans: Implications for direct radiometric dating. 3 Oct 2009
• Positron emission tomography measures of endogenous opioid neurotransmission and impulsiveness traits in humans. 29 Sep 2009
• Carbon-ion beam irradiation effectively suppresses migration and invasion of human non-small-cell lung cancer cells. 29 Sep 2009
• Synthesis and evaluation of a full-agonist orvinol for PET-imaging of opioid receptors: [11C]PEO. 22 Sep 2009
• Detection of aggressive primary prostate cancer with 11C-choline PET/CT using multimodality fusion techniques. 14 Sep 2009
• 2-18F-Fluoropropionic acid as a PET imaging agent for prostate cancer. 14 Sep 2009
• Evaluating dopamine reward pathway in ADHD: clinical implications. 7 Sep 2009
• Follow-up of [11C]PIB uptake and brain volume in patients with Alzheimer disease and controls. 31 Aug 2009
• Molecular ultrasound imaging of early vascular response in prostate tumors irradiated with carbon ions. 30 Aug 2009
• Changes in tumor volume of sacral chordoma after carbon ion radiotherapy. 30 Aug 2009
• Imaging left ventricular muscarinic receptor heterogeneity: a tool to evaluate individuals at risk for sudden death? 30 Aug 2009
• Lower level of endogenous dopamine in patients with cocaine dependence: findings from PET imaging of D(2)/D(3) receptors following acute dopamine depletion. 30 Aug 2009
• Influence of trigger PSA and PSA kinetics on 11C-Choline PET/CT detection rate in patients with biochemical relapse after radical prostatectomy. 16 Aug 2009
• The blood-brain barrier transport and cerebral distribution of guanidinoacetate in rats: involvement of creatine and taurine transporters. 15 Aug 2009
• Synthesis, in vitro and in vivo evaluation, and radiolabeling of aryl anandamide analogues as candidate radioligands for in vivo imaging of fatty acid amide hydrolase in the brain. 11 Aug 2009
• Decreased GABA-A binding on FMZ-PET in succinic semialdehyde dehydrogenase deficiency. 9 Aug 2009
• Age dependency of cerebral P-gp function measured with (R)-[11C]verapamil and PET. 3 Aug 2009

See a longer list of these articles.

Technical information about 'Carbon Radioisotopes'

Definition: Unstable isotopes of carbon that decay or disintegrate emitting radiation. C atoms with atomic weights 10, 11, and 14-16 are radioactive carbon isotopes.

Registry Number: 0

Descriptor UI: D002250

Alternative terms: Carbon Radioisotopes; Radioisotopes, Carbon;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; blood; cerebrospinal fluid; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Tree Number: D01.496.123.328; D01.496.749.154;

Online Note: search CARBON ISOTOPES 1966-73

History Note: 74

Technical Notes: C-10,11,14-16; NIM; /blood-csf-urine /metab permitted but not for tracer studies ( = /diag use)