Carbonic Anhydrase Inhibitors
Research News and Information

Friday, March 19, 2010

The taste of carbonation.

14 Oct 2009 Carbonated beverages are commonly available and immensely popular, but little is known about the cellular and molecular mechanisms underlying the perception of carbonation in the mouth. In mammals, carbonation elicits both somatosensory and ... Read more...

Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-binding, more isoform-selective inhibitors.

6 Oct 2009 Two approaches were used to design inhibitors of the metalloenzyme carbonic anhydrase (CA, EC 4.2.1.1): the tail and the ring approaches. Aliphatic sulfamates constitute a class of CA inhibitors (CAIs) that cannot be classified in either one of ... Read more...

Carbonic anhydrase-encoded dynamic constitutional libraries: toward the discovery of isozyme-specific inhibitors.

11 Aug 2009 A constitutional dynamic library (CDL) was generated under thermodynamic control by using the amino-carbonyl/imine interconversion as reversible chemistry, combined with noncovalent bonding within the active site of the metalloenzyme carbonic ... Read more...

Latest indexed articles for 'Carbonic Anhydrase Inhibitors'

These are the very latest articles for this heading:

• The taste of carbonation. 14 Oct 2009
• Neuroscience. Enzyme lets you enjoy the bubbly. 14 Oct 2009
• Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-binding, more isoform-selective inhibitors. 6 Oct 2009
• Carbonic anhydrase-encoded dynamic constitutional libraries: toward the discovery of isozyme-specific inhibitors. 11 Aug 2009
• Brinzolamide/timolol fixed combination: a new ocular suspension for the treatment of open-angle glaucoma and ocular hypertension. 30 Jul 2009
• Sildenafil is a strong activator of mammalian carbonic anhydrase isoforms I-XIV. 15 Jul 2009
• Discovery of low nanomolar and subnanomolar inhibitors of the mycobacterial beta-carbonic anhydrases Rv1284 and Rv3273. 7 Jul 2009
• Clinical Reasoning: a 22-year-old woman with headache and diplopia. 5 Jul 2009
• Coma resulting from spontaneous intracranial hypotension treated with the epidural blood patch in the Trendelenburg position pre-medicated with acetazolamide. Jul 2009
• Prevalence of uveitic secondary glaucoma and success of nonsurgical treatment in adults and children in a tertiary referral center. 29 Jun 2009
• Inhibition of carbonic anhydrase IX: a new strategy against cancer. 29 Jun 2009
• Taste disturbances related to medication use. 29 Jun 2009
• Perfusion computed tomography evaluation of cerebral hemodynamic impairment in patients with unilateral chronic steno-occlusive disease: a comparison with the acetazolamide challenge 99mTc-hexamethylpropyleneamine oxime single-photon emission computed tomography. 29 Jun 2009
• Expression and activity of carbonic anhydrase IX is associated with metabolic dysfunction in MDA-MB-231 breast cancer cells. 29 Jun 2009
• Bicarbonate Induces Vibrio cholerae virulence gene expression by enhancing ToxT activity. 27 Jun 2009
• Methazolamide does not impair respiratory work performance in anesthetized rabbits. 22 Jun 2009
• Carbonic anhydrase inhibitors: inhibition of cytosolic carbonic anhydrase isozymes II and VII with simple aromatic sulfonamides and some azo dyes. 20 Jun 2009
• An integrated microfluidic device for large-scale in situ click chemistry screening. 15 Jun 2009
• Carbonic anhydrase inhibitors. Inhibition of the beta-class enzyme from the pathogenic yeast Candida glabrata with anions. 14 Jun 2009
• Small-molecule suppression of misfolding of mutated human carbonic anhydrase II linked to marble brain disease. 14 Jun 2009

See a longer list of these articles.

Technical information about 'Carbonic Anhydrase Inhibitors'

Definition: A class of compounds that reduces the secretion of H+ ions by the proximal kidney tubule through inhibition of CARBONIC ANHYDRASES.

Registry Number: 0

Descriptor UI: D002257

Alternative terms: Carbonic Anhydrase Inhibitors; Inhibitors, Carbonic Anhydrase; Carbonate Dehydratase Inhibitors; Inhibitors, Carbonate Dehydratase; Carboxyanhydrase Inhibitors; Inhibitors, Carboxyanhydrase;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Tree Number: D27.505.519.389.200;

History Note: 65(64)

Technical Notes: DF: CARBONIC ANHYDRASE INHIB