Carcinogens - Toxicity
Research News and Information

Sunday, November 22, 2009

FoxO3a gene is a target of deletion in mouse lung adenocarcinoma.

29 Sep 2009 Lung adenocarcinomas (LAC) of smokers and never-smokers differ from one another in epidemiology, and clinical and molecular characteristics. The pathogenetic differences between these tumors are potential biomarkers and therapeutic targets. Mouse ... Read more...

Epigenetic modulation of the retinoid X receptor alpha by green tea in the azoxymethane-Apc Min/+ mouse model of intestinal cancer.

29 Sep 2009 We investigated the possible mechanisms of inhibition of colorectal carcinogenesis by green tea (GT) in azoxymethane-treated (AOM) Apc(Min/+) mice. Mice received water or a 0.6% (w/v) solution of GT as the only source of beverage. GT treatment ... Read more...

Targeted disruption of Bcl-xL in mouse keratinocytes inhibits both UVB- and chemically induced skin carcinogenesis.

29 Sep 2009 Bcl-x(L) is one of several antiapoptotic proteins regulated by signal transducer and activator of transcription 3 (Stat3). We have recently shown that Stat3 is required for chemically induced and ultraviolet B (UVB)-induced skin carcinogenesis. In ... Read more...

Latest indexed articles for 'Carcinogens - Toxicity'

These are the very latest articles for this heading:

• FoxO3a gene is a target of deletion in mouse lung adenocarcinoma. 29 Sep 2009
• Epigenetic modulation of the retinoid X receptor alpha by green tea in the azoxymethane-Apc Min/+ mouse model of intestinal cancer. 29 Sep 2009
• Targeted disruption of Bcl-xL in mouse keratinocytes inhibits both UVB- and chemically induced skin carcinogenesis. 29 Sep 2009
• Determinants of urinary 8-hydroxy-2'-deoxyguanosine in Chinese children with acute leukemia. 29 Sep 2009
• Morphological and biochemical changes associated with apoptosis induced by okadaic acid in human amniotic FL cells. 29 Sep 2009
• MMR/c-Abl-dependent activation of ING2/p73alpha signaling regulates the cell death response to N-methyl-N'-nitro-N-nitrosoguanidine. 15 Sep 2009
• Gene expression profiling during rat mammary carcinogenesis induced by 7,12-dimethylbenz[a]anthracene. 13 Sep 2009
• Correlations and co-localizations of Hsp70 with XPA, XPG in human bronchial epithelia cells exposed to benzo[a]pyrene. 9 Sep 2009
• Application of key events analysis to chemical carcinogens and noncarcinogens. 30 Aug 2009
• Molecular pathology of early stage chemically induced hepatocarcinogenesis. 30 Aug 2009
• Proteomics of rat prostate lobes treated with 2-N-hydroxylamino-1-methyl-6-phenylimidazo[4,5-b]pyridine, 5alpha-dihydrotestosterone, individually and in combination. 30 Aug 2009
• Cyclin D1 overexpression increases susceptibility to 4-nitroquinoline-1-oxide-induced dysplasia and neoplasia in murine squamous oral epithelium. 30 Aug 2009
• Multi-stage chemical carcinogenesis in mouse skin: fundamentals and applications. 25 Aug 2009
• Mutagenicity and potential carcinogenicity of thiopurine treatment in patients with inflammatory bowel disease. 23 Aug 2009
• Persistence of DNA damage following exposure of human bladder cells to chronic monomethylarsonous acid. 18 Aug 2009
• Finding transcriptomics biomarkers for in vivo identification of (non-)genotoxic carcinogens using wild-type and Xpa/p53 mutant mouse models. 18 Aug 2009
• A maternal high-fat diet during pregnancy in rats results in a greater risk of carcinogen-induced mammary tumors in the female offspring than exposure to a high-fat diet in postnatal life. 13 Aug 2009
• Indicators of oxidative stress and apoptosis in mouse whole lung and Clara cells following exposure to styrene and its metabolites. 6 Aug 2009
• [Nature is healthy] 30 Jul 2009
• 3,3'-diindolylmethane attenuates colonic inflammation and tumorigenesis in mice. 30 Jul 2009

See a longer list of these articles.

Technical information about 'Carcinogens'

Definition: Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.

Registry Number: 0

Descriptor UI: D002273

Alternative terms: Carcinogens; Oncogens; Tumor Initiators; Initiators, Tumor; Tumor Promoters; Promoters, Tumor;

Related Mesh Headings: Cocarcinogenesis; Mutagens; Oncogenic Viruses; Anticarcinogenic Agents;

Allowable Qualifiers: administration & dosage; analysis; chemical synthesis; classification; economics; history; isolation & purification; metabolism; pharmacokinetics; pharmacology; radiation effects; standards; supply & distribution; toxicity; chemistry; contraindications; antagonists & inhibitors;

Tree Number: D27.888.569.100;

Technical Notes: Manual 24.5.6.2+