Carcinogens
Research News and Information

Sunday, November 22, 2009

Exposure to the carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in smokers from 3 populations with different risks of lung cancer.

13 Nov 2009 Native Hawaiian smokers are at higher risk and Japanese-American smokers at lower risk of lung cancer (LC), compared with white smokers, even after accounting for smoking history. Because variation in carcinogen exposure/metabolism may occur ... Read more...

Involvement of cytosolic phospholipase A2alpha in MMP-9 up-regulation.

30 Oct 2009 Matrix metalloproteinase-9 (MMP-9) is important in the pathogenesis of periodontitis. Cytosolic phospholipase A(2)alpha (cPLA(2)alpha) is involved in MMP-9 up-regulation in human monocytes. We tested the hypothesis that cPLA(2)alpha also regulates ... Read more...

FoxO3a gene is a target of deletion in mouse lung adenocarcinoma.

29 Sep 2009 Lung adenocarcinomas (LAC) of smokers and never-smokers differ from one another in epidemiology, and clinical and molecular characteristics. The pathogenetic differences between these tumors are potential biomarkers and therapeutic targets. Mouse ... Read more...

Latest indexed articles for 'Carcinogens'

These are the very latest articles for this heading:

• Exposure to the carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in smokers from 3 populations with different risks of lung cancer. 13 Nov 2009
• Adiponectin is not effective against AOM-induced colon cancer but more evidence is required for its role in obesity-associated colon cancer: comment on the study by Ealey and Archer (2009). 13 Nov 2009
• Involvement of cytosolic phospholipase A2alpha in MMP-9 up-regulation. 30 Oct 2009
• FoxO3a gene is a target of deletion in mouse lung adenocarcinoma. 29 Sep 2009
• Epigenetic modulation of the retinoid X receptor alpha by green tea in the azoxymethane-Apc Min/+ mouse model of intestinal cancer. 29 Sep 2009
• Targeted disruption of Bcl-xL in mouse keratinocytes inhibits both UVB- and chemically induced skin carcinogenesis. 29 Sep 2009
• Determinants of urinary 8-hydroxy-2'-deoxyguanosine in Chinese children with acute leukemia. 29 Sep 2009
• Morphological and biochemical changes associated with apoptosis induced by okadaic acid in human amniotic FL cells. 29 Sep 2009
• Photodynamic therapy with 5-aminolevulinic acid and diamino acid derivatives of protoporphyrin IX reduces papillomas in mice without eliminating transformation into squamous cell carcinoma of the skin. 29 Sep 2009
• Inhibitory effects of honokiol on LPS and PMA-induced cellular responses of macrophages and monocytes. 28 Sep 2009
• MMR/c-Abl-dependent activation of ING2/p73alpha signaling regulates the cell death response to N-methyl-N'-nitro-N-nitrosoguanidine. 15 Sep 2009
• Gene expression profiling during rat mammary carcinogenesis induced by 7,12-dimethylbenz[a]anthracene. 13 Sep 2009
• Non-dioxin-like-PCBs phosphorylate Mdm2 at Ser166 and attenuate the p53 response in HepG2 cells. 10 Sep 2009
• Correlations and co-localizations of Hsp70 with XPA, XPG in human bronchial epithelia cells exposed to benzo[a]pyrene. 9 Sep 2009
• Elevated epithelial insulin-like growth factor expression is a risk factor for lung cancer development. 6 Sep 2009
• Artisanal alcohol production in Mayan Guatemala: chemical safety evaluation with special regard to acetaldehyde contamination. Sep 2009
• FDA: Electronic cigarettes may be risky. 31 Aug 2009
• Application of key events analysis to chemical carcinogens and noncarcinogens. 30 Aug 2009
• Molecular pathology of early stage chemically induced hepatocarcinogenesis. 30 Aug 2009
• Measuring microenvironment mechanical stress of rat liver during diethylnitrosamine induced hepatocarcinogenesis by atomic force microscope. 30 Aug 2009

See a longer list of these articles.

Technical information about 'Carcinogens'

Definition: Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.

Registry Number: 0

Descriptor UI: D002273

Alternative terms: Carcinogens; Oncogens; Tumor Initiators; Initiators, Tumor; Tumor Promoters; Promoters, Tumor;

Related Mesh Headings: Cocarcinogenesis; Mutagens; Oncogenic Viruses; Anticarcinogenic Agents;

Allowable Qualifiers: administration & dosage; analysis; chemical synthesis; classification; economics; history; isolation & purification; metabolism; pharmacokinetics; pharmacology; radiation effects; standards; supply & distribution; toxicity; chemistry; contraindications; antagonists & inhibitors;

Tree Number: D27.888.569.100;

Technical Notes: Manual 24.5.6.2+