Carcinoma, Non-Small-Cell Lung - Genetics
Research News and Information

Sunday, March 21, 2010

Detection of epidermal growth factor receptor mutations in plasma by mutant-enriched PCR assay for prediction of the response to gefitinib in patients with non-small-cell lung cancer.

13 Nov 2009 The high frequency of epidermal growth factor receptor (EGFR) mutations in tyrosine kinase inhibitor-responsive non-small-cell lung cancer (NSCLC) cases is now well established, highlighting the predictive value of activating EGFR mutations in ... Read more...

Molecular predictive and prognostic markers in non-small-cell lung cancer.

29 Sep 2009 Non-small-cell lung cancer (NSCLC) remains the leading cause of cancer death in the developed world. Platinum-based chemotherapy is the therapeutic foundation of treatment both in the metastatic and adjuvant setting and targeted therapies are ... Read more...

Lack of prognostic significance of serum DNA methylation of DAPK, MGMT, and GSTPI in patients with non-small cell lung cancer.

29 Sep 2009 BACKGROUND AND OBJECTIVES: To further improve the screening, diagnosis and therapy of patients with non-small cell lung cancer (NSCLC) additional diagnostic tools are desperately warranted. Aim of this study was to investigate the potential of the ... Read more...

Latest indexed articles for 'Carcinoma, Non-Small-Cell Lung - Genetics'

These are the very latest articles for this heading:

• Detection of epidermal growth factor receptor mutations in plasma by mutant-enriched PCR assay for prediction of the response to gefitinib in patients with non-small-cell lung cancer. 13 Nov 2009
• Molecular predictive and prognostic markers in non-small-cell lung cancer. 29 Sep 2009
• Lack of prognostic significance of serum DNA methylation of DAPK, MGMT, and GSTPI in patients with non-small cell lung cancer. 29 Sep 2009
• In situ evidence of KRAS amplification and association with increased p21 levels in non-small cell lung carcinoma. 29 Sep 2009
• Amplification of the ABCB1 region accompanied by a short sequence of 200bp from chromosome 2 in lung cancer cells. 29 Sep 2009
• Carbon-ion beam irradiation effectively suppresses migration and invasion of human non-small-cell lung cancer cells. 29 Sep 2009
• Apoptosis and autophagy: BIM as a mediator of tumour cell death in response to oncogene-targeted therapeutics. 27 Sep 2009
• Transcriptional regulation of vascular endothelial growth factor C by oxidative and thermal stress is mediated by lens epithelium-derived growth factor/p75. 30 Aug 2009
• Molecular analysis-based treatment strategies for the management of non-small cell lung cancer. 30 Aug 2009
• Impact of interaction of polymorphic forms of p53 codon 72 and N-acetylation gene (NAT2) on the risk of lung cancer in the North Indian population. 30 Aug 2009
• Morphology and a limited number of immunohistochemical markers may efficiently subtype non-small-cell lung cancer. 29 Aug 2009
• Screening for epidermal growth factor receptor mutations in lung cancer. 17 Aug 2009
• Personalized medicine and inhibition of EGFR signaling in lung cancer. 17 Aug 2009
• TGFBR1 haplotypes and risk of non-small-cell lung cancer. 16 Aug 2009
• Identification of nectin-4 oncoprotein as a diagnostic and therapeutic target for lung cancer. 13 Aug 2009
• Aryl hydrocarbon receptor activation and overexpression upregulated fibroblast growth factor-9 in human lung adenocarcinomas. 13 Aug 2009
• Clinical features and outcome of patients with non-small-cell lung cancer who harbor EML4-ALK. 8 Aug 2009
• EML4-ALK: honing in on a new target in non-small-cell lung cancer. 8 Aug 2009
• Deciphering the impact of common genetic variation on lung cancer risk: a genome-wide association study. 2 Aug 2009
• Nicotine stimulates PPARbeta/delta expression in human lung carcinoma cells through activation of PI3K/mTOR and suppression of AP-2alpha. 2 Aug 2009

See a longer list of these articles.

Technical information about 'Carcinoma, Non-Small-Cell Lung'

Definition: A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.

Descriptor UI: D002289

Alternative terms: Carcinoma, Non-Small-Cell Lung; Carcinoma, Non Small Cell Lung; Carcinomas, Non-Small-Cell Lung; Lung Carcinoma, Non-Small-Cell; Lung Carcinomas, Non-Small-Cell; Non-Small-Cell Lung Carcinomas; Carcinoma, Non-Small Cell Lung; Non-Small-Cell Lung Carcinoma; Non Small Cell Lung Carcinoma;

Related Mesh Headings: Adenocarcinoma; Carcinoma, Squamous Cell; Carcinoma, Large Cell; Carcinoma, Small Cell;

Allowable Qualifiers: blood; blood supply; cerebrospinal fluid; chemically induced; classification; complications; congenital; diagnosis; diet therapy; drug therapy; economics; embryology; enzymology; ethnology; etiology; genetics; history; immunology; metabolism; microbiology; mortality; nursing; epidemiology; parasitology; pathology; physiopathology; prevention & control; psychology; radiography; radionuclide imaging; radiotherapy; rehabilitation; secondary; secretion; surgery; therapy; ultrastructure; urine; veterinary; ultrasonography; chemistry; virology;

Tree Number: C04.588.894.797.520.220.249; C08.381.540.140.500; C08.785.520.140.500;

Online Note: use CARCINOMA, NON-SMALL-CELL LUNG to search CARCINOMA, NON-SMALL CELL LUNG 1987-93

History Note: 94; was CARCINOMA, NON-SMALL CELL LUNG 1987-93

Technical Notes: coordinate IM with LUNG NEOPLASMS (IM); CARCINOMA, LARGE CELL and SMALL CELL LUNG CARCINOMA are also available; DF: NSCLC