Catechin - Analogs & derivatives
Research News and Information

Tuesday, November 24, 2009

Cell growth inhibition and gene expression regulation by (-)-epigallocatechin-3-gallate in human cervical cancer cells.

24 Sep 2009 EGCG [(-)-epigallocatechin-3-gallate] has shown its antitumor ability and perhaps a potential regimen for cancer patients. The goal of this study was to investigate the effect of EGCG on human papilloma virus (HPV) positive cervical cancer cell ... Read more...

Apoptosis induction effects of EGCG in laryngeal squamous cell carcinoma cells through telomerase repression.

24 Sep 2009 Epigallocatechin-3-gallate (EGCG), the major component of green tea polyphenol, has potent efficiency to prevent the growth of a variety of cancer cells. As a novel anticancer agent for treatment of cancers, EGCG is promising and the mechanism has ... Read more...

Suppression of Met activation in human colon cancer cells treated with (-)-epigallocatechin-3-gallate: minor role of hydrogen peroxide.

6 Sep 2009 Colorectal cancer is the second leading cause of cancer-related deaths in the U.S. Met, the receptor for hepatocyte growth factor (HGF), is over-expressed in colon tumors and is associated with poor prognosis. Recently, the green tea polyphenol ... Read more...

Latest indexed articles for 'Catechin - Analogs & derivatives'

These are the very latest articles for this heading:

• Cell growth inhibition and gene expression regulation by (-)-epigallocatechin-3-gallate in human cervical cancer cells. 24 Sep 2009
• Apoptosis induction effects of EGCG in laryngeal squamous cell carcinoma cells through telomerase repression. 24 Sep 2009
• Suppression of Met activation in human colon cancer cells treated with (-)-epigallocatechin-3-gallate: minor role of hydrogen peroxide. 6 Sep 2009
• EGCG inhibits protein synthesis, lipogenesis, and cell cycle progression through activation of AMPK in p53 positive and negative human hepatoma cells. 30 Aug 2009
• Preservation of porcine hepatocytes in three-dimensional bioreactor at room temperature using epigallocatechin-3-gallate. 30 Aug 2009
• Study of the interactions between a proline-rich protein and a flavan-3-ol by NMR: residual structures in the natively unfolded protein provides anchorage points for the ligands. 30 Aug 2009
• Modulation of arsenic trioxide-induced apoptosis by genistein and functionally related agents in U937 human leukaemia cells. Regulation by ROS and mitogen-activated protein kinases. 27 Aug 2009
• Artefacts in cell culture: pyruvate as a scavenger of hydrogen peroxide generated by ascorbate or epigallocatechin gallate in cell culture media. 16 Aug 2009
• (-)-Epigallocatechin-3-gallate induces apoptosis of human hepatoma cells by mitochondrial pathways related to reactive oxygen species. 10 Aug 2009
• Green tea epigallocatechin-3-gallate inhibits microsomal prostaglandin E(2) synthase-1. 4 Aug 2009
• 50 Hz extremely low frequency electromagnetic fields enhance protein carbonyl groups content in cancer cells: effects on proteasomal systems. 3 Aug 2009
• Green tea (-)-epigallocatechin-3-gallate inhibits beta-amyloid-induced cognitive dysfunction through modification of secretase activity via inhibition of ERK and NF-kappaB pathways in mice. 3 Aug 2009
• Green tea polyphenol (-)-epigallocatechin-3-gallate enhances the inhibitory effect of huperzine A on acetylcholinesterase by increasing the affinity with serum albumin. 30 Jul 2009
• (-)-Epigallocatechin gallate attenuates the induction of HSP27 stimulated by sphingosine 1-phosphate via suppression of phosphatidylinositol 3-kinase/Akt pathway in osteoblasts. 30 Jul 2009
• UVB radiation induces human lens epithelial cell migration via NADPH oxidase-mediated generation of reactive oxygen species and up-regulation of matrix metalloproteinases. 30 Jul 2009
• Green tea catechin controls apoptosis in colon cancer cells by attenuation of H2O2-stimulated COX-2 expression via the AMPK signaling pathway at low-dose H2O2. 30 Jul 2009
• Inhibitory effects of green tea catechin on the lipid accumulation in 3T3-L1 adipocytes. 30 Jul 2009
• Effects of epigallocatechin gallate on the oral bioavailability and pharmacokinetics of tamoxifen and its main metabolite, 4-hydroxytamoxifen, in rats. 30 Jul 2009
• (-)-Epigallocatechin gallate prevents carbon tetrachloride-induced rat hepatic fibrosis by inhibiting the expression of the PDGFRbeta and IGF-1R. 28 Jul 2009
• (-)-Epigallocatechin-3-gallate (EGCG) sensitizes melanoma cells to interferon induced growth inhibition in a mouse model of human melanoma. 25 Jul 2009

See a longer list of these articles.

Technical information about 'Catechin'

Definition: An antioxidant flavonoid, occurring especially in woody plants as both (+)-catechin and (-)-epicatechin (cis) forms.

Chemical name: 2H-1-Benzopyran-3,5,7-triol, 2-(3,4-dihydroxyphenyl)-3,4-dihydro-, (2R-trans)-

Registry Number: 154-23-4

Descriptor UI: D002392

Alternative terms: Catechin; (+)-Cyanidanol; Cianidanol; Catechinic Acid; Acid, Catechinic; Catechuic Acid; Acid, Catechuic; (+)-Catechin; 3,3',4',5,7-Flavanpentol; Catergen; Zyma; Epicatechin; 2H-1-Benzopyran-3,5,7-triol, 2-(3,4-dihydroxyphenyl)-3,4-dihydro-, (2R-cis)-; KB-53; KB 53; KB53; Z 7300; (+)-Cyanidanol-3; Cyanidanol-3; Cyanidanol 3;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Tree Number: D03.438.150.240.190; D03.438.150.266.450.206; D03.830.219.240.190; D03.830.219.266.450.206;

History Note: 87(77); was see under BENZOPYRANS 1977-86