Catechol O-Methyltransferase
Research News and Information

Sunday, November 22, 2009

Common germline polymorphisms in COMT, CYP19A1, ESR1, PGR, SULT1E1 and STS and survival after a diagnosis of breast cancer.

29 Nov 2009 Although preliminary evidence suggests that germline variation in genes involved in steroid hormone metabolism may alter breast cancer prognosis, this has not been systematically evaluated. We examined associations between germline polymorphisms in ... Read more...

The functional Val158Met polymorphism of COMT predicts interindividual differences in brain alpha oscillations in young men.

31 Aug 2009 Individual patterns of the electroencephalogram (EEG) in wakefulness and sleep are among the most heritable traits in humans, yet distinct genetic and neurochemical mechanisms underlying EEG phenotypes are largely unknown. A functional polymorphism ... Read more...

[Implication of genetic polymorphism on neuropathic pain]

30 Aug 2009 Various conditions are categorized to neuropathic pain, many of which are intractable requiring investigation using multiple approaches. Genetic polymorphism is one of such research fields that have provided much insight into conditions including ... Read more...

Latest indexed articles for 'Catechol O-Methyltransferase'

These are the very latest articles for this heading:

• Common germline polymorphisms in COMT, CYP19A1, ESR1, PGR, SULT1E1 and STS and survival after a diagnosis of breast cancer. 29 Nov 2009
• The functional Val158Met polymorphism of COMT predicts interindividual differences in brain alpha oscillations in young men. 31 Aug 2009
• [Implication of genetic polymorphism on neuropathic pain] 30 Aug 2009
• [Genetic polymorphisms and human sensitivity to pain and opioids] 30 Aug 2009
• Aromatic hydroxylation is a major metabolic pathway of the mycotoxin zearalenone in vitro. 30 Aug 2009
• The C-glycosyl flavonoid, aspalathin, is absorbed, methylated and glucuronidated intact in humans. 30 Aug 2009
• Association between COMT gene and Chinese male schizophrenic patients with violent behavior. 30 Aug 2009
• Monoamine oxidase a and catechol-o-methyltransferase functional polymorphisms and the placebo response in major depressive disorder. 30 Jul 2009
• Effect of genetic factors on opioid action. 30 Jul 2009
• Medical treatment of Parkinson disease. 30 Jul 2009
• Catechol O-methyltransferase pharmacogenomics: human liver genotype-phenotype correlation and proximal promoter studies. 30 Jul 2009
• Variants in COMT and spontaneous smoking cessation: retrospective cohort analysis of 925 cessation events. 30 Jul 2009
• Should I stay or should I go: genetic bases for uncertainty-driven exploration. 30 Jul 2009
• COMT val(158)met genotype and smooth pursuit eye movements in schizophrenia. 29 Jul 2009
• Epistasis between the DAT 3' UTR VNTR and the COMT Val158Met SNP on cortical function in healthy subjects and patients with schizophrenia. 26 Jul 2009
• Prefrontal and striatal dopaminergic genes predict individual differences in exploration and exploitation. 18 Jul 2009
• The development of peripartum depressive symptoms is associated with gene polymorphisms of MAOA, 5-HTT and COMT. 17 Jul 2009
• Effects of catechol-O-methyltransferase on normal variation in the cognitive function of children. 13 Jul 2009
• A hotspot of inactivation: The A22S and V108M polymorphisms individually destabilize the active site structure of catechol O-methyltransferase. 12 Jul 2009
• COMT Val 158 Met polymorphism is associated with cognitive flexibility in a signal discrimination task in schizophrenia. 5 Jul 2009

See a longer list of these articles.

Technical information about 'Catechol O-Methyltransferase'

Definition: Enzyme that catalyzes the movement of a methyl group from S-adenosylmethionone to a catechol or a catecholamine. EC 2.1.1.6.

Chemical name: S-Adenosyl-L-methionine:catechol O-methyltransferase

Registry Number: EC 2.1.1.6

Descriptor UI: D002394

Alternative terms: Catechol O-Methyltransferase; O-Methyltransferase, Catechol; Catechol Methyltransferase; Methyltransferase, Catechol; Catechol-O-Methyltransferase; Catechol O Methyltransferase;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications;

Tree Number: D08.811.913.555.500.250;

History Note: 98(72)