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Cell Adhesion Molecules, Neuronal - Pharmacology
Research News and Information
Definition of 'Cell Adhesion Molecules, Neuronal'Surface ligands that mediate cell-to-cell adhesion and function in the assembly and interconnection of the vertebrate nervous system. These molecules promote cell adhesion via a homophilic mechanism. These are not to be confused with NEURAL CELL ADHESION MOLECULES, now known to be expressed in a variety of tissues and cell types in addition to nervous tissue. Common names: Cell Adhesion Molecules, Neuronal; Neuronal Cell Adhesion Molecules; Axon-Associated Adhesion Molecules; Adhesion Molecules, Axon-Associated; Axon Associated Adhesion Molecules; Molecules, Axon-Associated Adhesion |
Sunday, March 14, 2010
Reelin signaling antagonizes beta-amyloid at the synapse.
31 Aug 2009 
Abnormal processing of the amyloid precursor protein (APP) and beta-amyloid (Abeta) plaque accumulation are defining features of Alzheimer disease (AD), a genetically complex neurodegenerative disease that is characterized by progressive synapse ... Read more...
Reelin and Notch1 cooperate in the development of the dentate gyrus.
29 Jun 2009 The development of the hippocampal dentate gyrus is a complex process in which several signaling pathways are involved and likely interact with each other. The extracellular matrix molecule Reelin is necessary both for normal development of the ... Read more...
Physiological response of bovine subcommissural organ to endothelin 1 and bradykinin.
20 Apr 2009 The circumventricular organs (CVOs) regulate certain vegetative functions. Receptors for bradykinin (BDK) and endothelin (ET) have been found in some CVOs. The subcommissural organ (SCO) is a CVO expressing BDK-B2 receptors and secreting Reissner's ... Read more...
Latest indexed articles for 'Cell Adhesion Molecules, Neuronal - Pharmacology'
These are the very latest articles for this heading:
- Reelin signaling antagonizes beta-amyloid at the synapse. 31 Aug 2009
- Reelin and Notch1 cooperate in the development of the dentate gyrus. 29 Jun 2009
- Physiological response of bovine subcommissural organ to endothelin 1 and bradykinin. 20 Apr 2009
- Reelin stabilizes the actin cytoskeleton of neuronal processes by inducing n-cofilin phosphorylation at serine3.
5 Jan 2009 - Amalgam, an axon guidance Drosophila adhesion protein belonging to the immunoglobulin superfamily: over-expression, purification and biophysical characterization. 6 Oct 2008
- Morphological and functional characterization of predifferentiation of myelinating glia-like cells from human bone marrow stromal cells through activation of F3/Notch signaling in mouse retina. 30 Oct 2007
- Reelin and mDab1 regulate the development of hippocampal connections. 16 Jul 2007
- Reelin regulates neuronal progenitor migration in intact and epileptic hippocampus. 19 Feb 2007
- Early coevolution of adhesive but not antiadhesive tenascin-R ligand-receptor pairs in vertebrates: a phylogenetic study. 8 Jul 2006
- Reelin induces the detachment of postnatal subventricular zone cells and the expression of the Egr-1 through Erk1/2 activation. 28 Feb 2006
- Long-term engagement of CD6 and ALCAM is essential for T-cell proliferation induced by dendritic cells. 11 Dec 2005
- Both the phosphoinositide and receptor binding activities of Dab1 are required for Reelin-stimulated Dab1 tyrosine phosphorylation. Oct 2005
- Ninjurin1 increases p21 expression and induces cellular senescence in human hepatoma cells. 29 Sep 2004
- Interaction between Dab1 and CrkII is promoted by Reelin signaling. 15 Aug 2004
- Apolipoprotein E receptors are required for reelin-induced proteasomal degradation of the neuronal adaptor protein Disabled-1. 31 May 2004
- Neuroglian and FasciclinII can promote neurite outgrowth via the FGF receptor Heartless. 30 May 2004
- Activation of a Dab1/CrkL/C3G/Rap1 pathway in Reelin-stimulated neurons. 4 Apr 2004
- Characterization of a fasciclin I-like protein with cell attachment activity from sea urchin (Strongylocentrotus intermedius) ovaries. 30 Mar 2004
- Regulation of protein tyrosine kinase signaling by substrate degradation during brain development. 29 Nov 2003
- F3/contactin acts as a functional ligand for Notch during oligodendrocyte maturation. 15 Oct 2003
See a longer list of these articles.
Technical information about 'Cell Adhesion Molecules, Neuronal'
Definition: Surface ligands that mediate cell-to-cell adhesion and function in the assembly and interconnection of the vertebrate nervous system. These molecules promote cell adhesion via a homophilic mechanism. These are not to be confused with NEURAL CELL ADHESION MOLECULES, now known to be expressed in a variety of tissues and cell types in addition to nervous tissue.
Registry Number: 0
Descriptor UI: D015816
Alternative terms: Cell Adhesion Molecules, Neuronal; Neuronal Cell Adhesion Molecules; Axon-Associated Adhesion Molecules; Adhesion Molecules, Axon-Associated; Axon Associated Adhesion Molecules; Molecules, Axon-Associated Adhesion;
Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists;
Tree Number: D12.776.395.550.200.250; D12.776.543.550.200.250; D23.050.301.350.250;
History Note: 90
Technical Notes: do not confuse with CELL ADHESION MOLECULES, NEURON-GLIA; do not confuse X ref NEURONAL CELL ADHESION MOLECULES with NCAM for X ref NEURAL CELL ADHESION MOLECULE