Cell Death - Drug effects
Research News and Information

Monday, November 23, 2009

Brain-derived neurotrophic factor protects cementoblasts from serum starvation-induced cell death.

29 Nov 2009 Our previous studies have shown that brain-derived neurotrophic factor (BDNF) enhances bone/cementum-related protein gene expression through the TrkB-c-Raf-ERK1/2-Elk-1 signaling pathway in cementoblasts, which play a critical role in the ... Read more...

Estrogen attenuates ischemic oxidative damage via an estrogen receptor alpha-mediated inhibition of NADPH oxidase activation.

2 Nov 2009 The goal of this study was to elucidate the mechanisms of 17beta-estradiol (E(2)) antioxidant and neuroprotective actions in stroke. The results reveal a novel extranuclear receptor-mediated antioxidant mechanism for E(2) during stroke, as well as a ... Read more...

Disruption of the axon initial segment cytoskeleton is a new mechanism for neuronal injury.

19 Oct 2009 Many factors contribute to nervous system dysfunction and failure to regenerate after injury or disease. Here, we describe a previously unrecognized mechanism for nervous system injury. We show that neuronal injury causes rapid, irreversible, and ... Read more...

Latest indexed articles for 'Cell Death - Drug effects'

These are the very latest articles for this heading:

• Brain-derived neurotrophic factor protects cementoblasts from serum starvation-induced cell death. 29 Nov 2009
• Estrogen attenuates ischemic oxidative damage via an estrogen receptor alpha-mediated inhibition of NADPH oxidase activation. 2 Nov 2009
• Disruption of the axon initial segment cytoskeleton is a new mechanism for neuronal injury. 19 Oct 2009
• Endogenous Jmjd6 gene product is expressed at the cell surface and regulates phagocytosis in immature monocyte-like activated THP-1 cells. 29 Sep 2009
• Inhibition of the c-Abl-TAp63 pathway protects mouse oocytes from chemotherapy-induced death. 25 Sep 2009
• Endothelial protein C receptor is expressed in rat cortical and hippocampal neurons and is necessary for protective effect of activated protein C at glutamate excitotoxicity. 23 Sep 2009
• Critical role of TLR4 response in the activation of microglia induced by ethanol. 12 Sep 2009
• Decursin inhibits retinal neovascularization via suppression of VEGFR-2 activation. 10 Sep 2009
• Immunotoxin-induced ablation of melanopsin retinal ganglion cells in a non-murine mammalian model. 8 Sep 2009
• Cis-urocanic acid suppresses UV-B-induced interleukin-6 and -8 secretion and cytotoxicity in human corneal and conjunctival epithelial cells in vitro. 6 Sep 2009
• CaMKII phosphorylates collapsin response mediator protein 2 and modulates axonal damage during glutamate excitotoxicity. 5 Sep 2009
• Suppression of hippocampal TRPM7 protein prevents delayed neuronal death in brain ischemia. 4 Sep 2009
• In vitro translocation of quantum dots and influence of oxidative stress. 2 Sep 2009
• Oxidative injury triggers autophagy in astrocytes: the role of endogenous zinc. 30 Aug 2009
• Postischemic treatment of neonatal cerebral ischemia should target autophagy. 30 Aug 2009
• Endothelial cell loss during pterygium surgery: importance of timing of mitomycin C application. 30 Aug 2009
• Cell death induced by N-methyl-N-nitrosourea, a model S(N)1 methylating agent, in two lung cancer cell lines of human origin. 30 Aug 2009
• Rapamycin, the mTOR kinase inhibitor, sensitizes acute myeloid leukemia cells, HL-60 cells, to the cytotoxic effect of arabinozide cytarabine. 30 Aug 2009
• The antipsychotic drug chlorpromazine enhances the cytotoxic effect of tamoxifen in tamoxifen-sensitive and tamoxifen-resistant human breast cancer cells. 30 Aug 2009
• Involvement of N-acetyltransferase human in the cytotoxic activity of 5-fluorouracil. 30 Aug 2009

See a longer list of these articles.

Technical information about 'Cell Death'

Definition: The termination of the cell's ability to carry out vital functions such as metabolism, growth, reproduction, responsiveness, and adaptability.

Descriptor UI: D016923

Alternative terms: Cell Death; Death, Cell;

Related Mesh Headings: Necrosis; Apoptosis;

Allowable Qualifiers: drug effects; genetics; immunology; physiology; radiation effects; ethics;

Tree Number: G04.299.139;

Online Note: use CELL SURVIVAL to search CELL DEATH 1978-91

History Note: 92; was see CELL SURVIVAL 1978-91

Technical Notes: NIM; not for micro-organisms