Cell Degranulation
Research News and Information

Sunday, November 22, 2009

Kinetics of early T cell receptor signaling regulate the pathway of lytic granule delivery to the secretory domain.

14 Oct 2009 Cytolytic granules mediate killing of virus-infected cells by cytotoxic T lymphocytes. We show here that the granules can take long or short paths to the secretory domain. Both paths utilized the same intracellular molecular events, which have ... Read more...

The strength of T cell receptor signal controls the polarization of cytotoxic machinery to the immunological synapse.

14 Oct 2009 Killing by cytotoxic T lymphocytes (CTLs) is mediated by the secretion of lytic granules. The centrosome plays a key role in granule delivery, polarizing to the central supramolecular activation complex (cSMAC) within the immunological synapse upon ... Read more...

A view to a kill: how ligand quality controls lethal hits.

14 Oct 2009 In this issue of Immunity, Beal et al. (2009) and Jenkins et al. (2009) demonstrate that relatively weak stimuli support synapse formation and microtubule polarization, but fail to trigger efficient killing because of their inability to recruit ... Read more...

Latest indexed articles for 'Cell Degranulation'

These are the very latest articles for this heading:

• Kinetics of early T cell receptor signaling regulate the pathway of lytic granule delivery to the secretory domain. 14 Oct 2009
• The strength of T cell receptor signal controls the polarization of cytotoxic machinery to the immunological synapse. 14 Oct 2009
• A view to a kill: how ligand quality controls lethal hits. 14 Oct 2009
• Synthesis and evaluation of lysophosphatidylserine analogues as inducers of mast cell degranulation. Potent activities of lysophosphatidylthreonine and its 2-deoxy derivative. 6 Oct 2009
• Mast cell-mediated antigen presentation regulates CD8+ T cell effector functions. 6 Oct 2009
• Mechanisms of mast cell signaling in anaphylaxis. 29 Sep 2009
• Phospholipase d promotes lipid microdomain-associated signaling events in mast cells. 28 Sep 2009
• Eosinophils oxidize damage-associated molecular pattern molecules derived from stressed cells. 28 Sep 2009
• Dendritic cells support the in vivo development and maintenance of NK cells via IL-15 trans-presentation. 26 Sep 2009
• SH2 domain-containing phosphatase-2 protein-tyrosine phosphatase promotes Fc(epsilon)RI-induced activation of Fyn and Erk pathways leading to TNF(alpha) release from bone marrow-derived mast cells. 26 Sep 2009
• Effect of permethrin insecticide on rat polymorphonuclear neutrophils. 18 Sep 2009
• Molecular hydrogen suppresses FcepsilonRI-mediated signal transduction and prevents degranulation of mast cells. 15 Sep 2009
• Heat shock protein-90 inhibitors increase MHC class I-related chain A and B ligand expression on multiple myeloma cells and their ability to trigger NK cell degranulation. 9 Sep 2009
• Eosinophil degranulation patterns in nasal polyposis: an ultrastructural study. 30 Aug 2009
• Inhibition of IgE-induced mast cell activation by ethyl tertiary-butyl ether, a bioethanol-derived fuel oxygenate. 30 Aug 2009
• Interleukin-21 induces the differentiation of human umbilical cord blood CD34-lineage- cells into pseudomature lytic NK cells. 25 Aug 2009
• Inhibitory effect of carotenoids on the degranulation of mast cells via suppression of antigen-induced aggregation of high affinity IgE receptors. 19 Aug 2009
• Influence of timing of postexercise carbohydrate-protein ingestion on selected immune indices. 30 Jul 2009
• The basophil activation test in immediate-type drug allergy. 30 Jul 2009
• Neutrophils launch monocyte extravasation by release of granule proteins. 30 Jul 2009

See a longer list of these articles.

Technical information about 'Cell Degranulation'

Definition: The process of losing secretory granules (SECRETORY VESICLES). This occurs, for example, in mast cells, basophils, neutrophils, eosinophils, and platelets when secretory products are released from the granules by EXOCYTOSIS.

Descriptor UI: D015550

Alternative terms: Cell Degranulation; Degranulation, Cell;

Related Mesh Headings: Exocytosis; Secretory Vesicles;

Allowable Qualifiers: drug effects; genetics; immunology; physiology; radiation effects; ethics;

Tree Number: G04.299.490.160;

History Note: 90

Technical Notes: IM; coord with specific cell /physiol (IM)