Central Nervous System Stimulants - Toxicity
Research News and Information

Sunday, November 22, 2009

Spinal ERK activation via NO-cGMP pathway contributes to nociceptive behavior induced by morphine-3-glucuronide.

5 Jul 2009 Intrathecal (i.t.) injection of morphine-3-glucuronide (M3G), a major metabolite of morphine without analgesic actions, produces a severe hindlimb scratching followed by biting and licking in mice. The pain-related behavior evoked by M3G was ... Read more...

Tissue kallikrein protects cortical neurons against in vitro ischemia-acidosis/reperfusion-induced injury through the ERK1/2 pathway.

30 Jun 2009 Human tissue kallikrein (hTK) gene transfer has been shown to protect neurons against cerebral ischemia/reperfusion (I/R) injury, and exogenous tissue kallikrein (TK) administration can enhance neurogenesis and angiogenesis following focal cortical ... Read more...

Altered neurometabolites and motor integration in children exposed to methamphetamine in utero.

29 Jun 2009 Methamphetamine (METH) is a neurotoxic drug. This study aimed to evaluate brain metabolite levels and cognitive function in young children with prenatal METH exposure. 101 children ages 3-4 years were evaluated with neuropsychological tests and ... Read more...

Latest indexed articles for 'Central Nervous System Stimulants - Toxicity'

These are the very latest articles for this heading:

• Spinal ERK activation via NO-cGMP pathway contributes to nociceptive behavior induced by morphine-3-glucuronide. 5 Jul 2009
• Tissue kallikrein protects cortical neurons against in vitro ischemia-acidosis/reperfusion-induced injury through the ERK1/2 pathway. 30 Jun 2009
• Altered neurometabolites and motor integration in children exposed to methamphetamine in utero. 29 Jun 2009
• Methamphetamine treatment causes delayed decrease in novelty-induced locomotor activity in mice. 22 Jun 2009
• [Differences in neuronal toxicity and its molecular mechanisms between methamphetamine and methylphenidate] 30 May 2009
• Effects of prenatal methamphetamine exposure on verbal memory revealed with functional magnetic resonance imaging. 30 May 2009
• Characterisation of the effects of caffeine on sleep in the rat: a potential model of sleep disruption. 22 Apr 2009
• Priming for L-DOPA-induced abnormal involuntary movements increases the severity of amphetamine-induced dyskinesia in grafted rats. 20 Apr 2009
• Juvenile methylphenidate exposure and factors that influence incentive processing. 15 Apr 2009
• Effects on sleep stages and microarchitecture of caffeine and its combination with zolpidem or trazodone in healthy volunteers. 5 Apr 2009
• Methamphetamine- and trauma-induced brain injuries: comparative cellular and molecular neurobiological substrates. 3 Apr 2009
• Methamphetamine toxicity and messengers of death. 23 Mar 2009
• The effect of naltrexone on amphetamine-induced conditioned place preference and locomotor behaviour in the rat. 3 Mar 2009
• Age-dependent differences in dopamine transporter and vesicular monoamine transporter-2 function and their implications for methamphetamine neurotoxicity. 30 Jan 2009
• Increased synapses in the medial prefrontal cortex are associated with repeated amphetamine administration. 30 Jan 2009
• Effects of neuronal Kv7 potassium channel activators on hyperactivity in a rodent model of mania. 29 Dec 2008
• Synaptic and behavioral interactions of oseltamivir (Tamiflu) with neurostimulants. 29 Nov 2008
• Coffee consumption and risk of type 2 diabetes, cardiovascular diseases, and cancer. 29 Nov 2008
• Methylphenidate and amphetamine do not induce cytogenetic damage in lymphocytes of children with ADHD. 29 Nov 2008
• HIV sex risk behaviors among heterosexual methamphetamine users: literature review from 2000 to present. 30 Oct 2008

See a longer list of these articles.

Technical information about 'Central Nervous System Stimulants'

Definition: A loosely defined group of drugs that tend to increase behavioral alertness, agitation, or excitation. They work by a variety of mechanisms, but usually not by direct excitation of neurons. The many drugs that have such actions as side effects to their main therapeutic use are not included here.

Registry Number: 0

Descriptor UI: D000697

Alternative terms: Central Nervous System Stimulants; Central Stimulants; Stimulants, Central; Analeptics; Analeptic Drugs; Drugs, Analeptic; Analeptic Agents; Agents, Analeptic;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Tree Number: D27.505.696.282; D27.505.954.427.220;

Online Note: use CENTRAL NERVOUS SYSTEM STIMULANTS to search ANALEPTICS 1966-94

History Note: 95; was ANALEPTICS 1963-94; CENTRAL NERVOUS SYSTEM STIMULANTS was see ANALEPTICS 1985-94

Technical Notes: GEN or unspecified; prefer specifics; consider also CENTRAL NERVOUS SYSTEM /drug eff & BRAIN /drug eff; DF: CNS STIMULANTS