Chlordecone
Research News and Information

Sunday, March 21, 2010

Long-term pollution by chlordecone of tropical volcanic soils in the French West Indies: a simple leaching model accounts for current residue.

21 Jan 2009 Chlordecone was applied between 1972 and 1993 in banana fields of the French West Indies. This resulted in long-term pollution of soils and contamination of waters, aquatic biota, and crops. To assess pollution level and duration according to soil ... Read more...

A comparison of relative quantification with isobaric tags on a subset of the murine hepatic proteome using electrospray ionization quadrupole time-of-flight and matrix-assisted laser desorption/ionization tandem time-of-flight.

29 Sep 2008 The use of isobaric tagging for relative and absolute quantification (iTRAQ) has increased dramatically over the past few years. Many factors can affect the accuracy of quantification. Some of these include the number of biological/technical ... Read more...

Comparison of chlordecone and estradiol effects on splenic T-cells in (NZBxNZW)F(1) mice.

16 Sep 2008 Previous studies have shown that treatment of ovariectomized females with 17-beta estradiol (E2) accelerates the development of autoimmunity in the (NZBxNZW)F(1) murine lupus model. Treatment with estrogenic organochlorine pesticides (OCPs) such as ... Read more...

Latest indexed articles for 'Chlordecone'

These are the very latest articles for this heading:

• Long-term pollution by chlordecone of tropical volcanic soils in the French West Indies: a simple leaching model accounts for current residue. 21 Jan 2009
• A comparison of relative quantification with isobaric tags on a subset of the murine hepatic proteome using electrospray ionization quadrupole time-of-flight and matrix-assisted laser desorption/ionization tandem time-of-flight. 29 Sep 2008
• Comparison of chlordecone and estradiol effects on splenic T-cells in (NZBxNZW)F(1) mice. 16 Sep 2008
• Chlordecone, a mixed pregnane X receptor (PXR) and estrogen receptor alpha (ERalpha) agonist, alters cholesterol homeostasis and lipoprotein metabolism in C57BL/6 mice. 24 Aug 2008
• [Chlordecone and cancer in French-West Indies] 6 Aug 2008
• Ligand structure-dependent activation of estrogen receptor alpha/Sp by estrogens and xenoestrogens. 21 Feb 2008
• Chlordecone altered hepatic disposition of [14C]cholesterol and plasma cholesterol distribution but not SR-BI or ABCG8 proteins in livers of C57BL/6 mice. 4 Feb 2008
• Diminished prolactin from chlordecone treatment in ovariectomized (NZBxNZW)F(1) mice. 15 Sep 2007
• Increased level of cellular Bip critically determines estrogenic potency for a xenoestrogen kepone in the mouse uterus. 17 Jul 2007
• Acceleration of autoimmunity by organochlorine pesticides: a comparison of splenic B-cell effects of chlordecone and estradiol in (NZBxNZW)F1 mice. 17 Jun 2007
• Cytotoxic effects and aromatase inhibition by xenobiotic endocrine disrupters alone and in combination. 23 May 2007
• Impact of subsistence production on the management options to reduce the food exposure of the Martinican population to Chlordecone. 4 May 2007
• Hepatic sequestration of chlordecone and hexafluoroacetone evaluated by pharmacokinetic modeling. 15 Feb 2007
• Effect of sublethal exposure to chlordecone on life history characteristics of freshwater rotifer Brachionus calyciflorus pallas. 30 Dec 2006
• Binding and activation of the seven-transmembrane estrogen receptor GPR30 by environmental estrogens: a potential novel mechanism of endocrine disruption. 5 Nov 2006
• QSAR prediction of estrogen activity for a large set of diverse chemicals under the guidance of OECD principles. 30 Oct 2006
• Effects of prenatal chlordecone on sexually differentiated behavior in adult rats. 18 Oct 2006
• Activation of alpha- and beta-estrogen receptors by persistent pesticides in reporter cell lines. 25 Mar 2006
• Rapid effects of pesticides on human granulosa-lutein cells. 30 Jan 2006
• Activation of kinase pathways in MCF-7 cells by 17beta-estradiol and structurally diverse estrogenic compounds. 16 Jan 2006

See a longer list of these articles.

Technical information about 'Chlordecone'

Definition: A highly chlorinated polycyclic hydrocarbon insecticide whose large number of chlorine atoms makes it resistant to degradation. It has been shown to be toxic to mammals and causes abnormal cellular changes in laboratory animals.

Chemical name: 1,3,4-Metheno-2H-cyclobuta(cd)pentalen-2-one, 1,1a,3,3a,4,5,5,5a,5b,6-decachlorooctahydro-

Registry Number: 143-50-0

Descriptor UI: D007631

Alternative terms: Chlordecone; Kepone;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: Insecticides;

Tree Number: D02.455.526.439.190;

History Note: 96; was KEPONE 1977-95 (see under INSECTICIDES, ORGANOCHLORINE 1977-90); CHLORDECONE was see KEPONE 1977-95

Technical Notes: TN 111 for eff on insects