Cholera Toxin - Metabolism
Research News and Information

Sunday, November 22, 2009

Vibrio cholerae LexA coordinates CTX prophage gene expression.

5 Aug 2009 The filamentous bacteriophage CTX Phi transmits the cholera toxin genes by infecting and lysogenizing its host, Vibrio cholerae. CTX Phi genes required for virion production initiate transcription from the strong P(A) promoter, which is dually ... Read more...

The density of GM1-enriched lipid rafts correlates inversely with the efficiency of transfection mediated by cationic liposomes.

30 Jul 2009 Although cationic liposome-mediated transfection has become a standard procedure, the mechanistic details of the process are unknown. It has been suggested that endocytic uptake of lipoplexes is efficient, and transfectability is largely determined ... Read more...

The efficacy of the fluorescent conjugates of cholera toxin subunit B for multiple retrograde tract tracing in the central nervous system.

19 Jul 2009 Cholera toxin subunit B (CTB) is a sensitive neuroanatomical tracer that generally transports retrogradely in the nervous system, and has been used extensively in brightfield microscopy. Recently, Alexa Fluor (AF) conjugates of CTB have been made ... Read more...

Latest indexed articles for 'Cholera Toxin - Metabolism'

These are the very latest articles for this heading:

• A new twist on a classic paradigm: illumination of a genetic switch in Vibrio cholerae phage CTX Phi. 9 Sep 2009
• Vibrio cholerae LexA coordinates CTX prophage gene expression. 5 Aug 2009
• The density of GM1-enriched lipid rafts correlates inversely with the efficiency of transfection mediated by cationic liposomes. 30 Jul 2009
• The efficacy of the fluorescent conjugates of cholera toxin subunit B for multiple retrograde tract tracing in the central nervous system. 19 Jul 2009
• Structural and molecular mechanism for autoprocessing of MARTX toxin of Vibrio cholerae at multiple sites. 18 Jul 2009
• The formation of acetylcholine receptor clusters visualized with quantum dots. 14 Jul 2009
• Production of Ascaris suum As14 protein and its fusion protein with cholera toxin B subunit in rice seeds. 29 Jun 2009
• Nitric oxide as an endogenous peripheral modulator of visceral sensory neuronal function. Jun 2009
• Differential modulation of NF-kappaB-mediated pro-inflammatory response in human intestinal epithelial cells by cheY homologues of Vibrio cholerae. 30 May 2009
• Cholera toxin inhibits IL-12 production and CD8alpha+ dendritic cell differentiation by cAMP-mediated inhibition of IRF8 function. 30 May 2009
• Characteristics of rostral solitary tract nucleus neurons with identified afferent connections that project to the parabrachial nucleus in rats. 11 May 2009
• Tight junctions, intestinal permeability, and autoimmunity: celiac disease and type 1 diabetes paradigms. 29 Apr 2009
• Selective toxin sequestrants for the treatment of bacterial infections. 27 Apr 2009
• Galactooligosaccharides (GOS) inhibit Vibrio cholerae toxin binding to its GM1 receptor. 20 Apr 2009
• Endocytosis of MHC molecules by distinct membrane rafts. 19 Apr 2009
• Cloning, expression, purification and characterization of the cholera toxin B subunit and triple glutamic acid decarboxylase epitopes fusion protein in Escherichia coli. 9 Apr 2009
• ADP-ribosylation factors regulate the development of CT signaling in immature human enterocytes. 7 Apr 2009
• Sorting of lipids and proteins in membrane curvature gradients. 6 Apr 2009
• Zonulin is not increased in the cardiac and esophageal mucosa of patients with gastroesophageal reflux disease. 3 Apr 2009
• Single nanoparticle tracking-based detection of membrane receptor-ligand interactions. 30 Mar 2009

See a longer list of these articles.

Technical information about 'Cholera Toxin'

Definition: An ENTEROTOXIN from VIBRIO CHOLERAE. It consists of two major protomers, the heavy (H) or A subunit and the B protomer which consists of 5 light (L) or B subunits. The catalytic A subunit is proteolytically cleaved into fragments A1 and A2. The A1 fragment is a MONO(ADP-RIBOSE) TRANSFERASE. The B protomer binds cholera toxin to intestinal epithelial cells, and facilitates the uptake of the A1 fragment. The A1 catalyzed transfer of ADP-RIBOSE to the alpha subunits of heterotrimeric G PROTEINS activates the production of CYCLIC AMP. Increased levels of cyclic AMP are thought to modulate release of fluid and electrolytes from intestinal crypt cells.

Registry Number: 9012-63-9

Descriptor UI: D002772

Alternative terms: Cholera Toxin; Toxin, Cholera; Cholera Exotoxin; Exotoxin, Cholera; Choleragen; Cholera Enterotoxin CT; CT, Cholera Enterotoxin; Enterotoxin CT, Cholera; Procholeragenoid; Cholera Toxin Protomer A; Cholera Toxin A Subunit; Choleragenoid; Cholera Toxin Protomer B; Cholera Toxin B Subunit;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: Poisons; Adjuvants, Immunologic;

Tree Number: D08.811.913.400.725.115.180; D23.946.123.194; D23.946.330.150;

History Note: 78

Technical Notes: /antag permitted but consider also ANTITOXINS