Choline - Antagonists & inhibitors
Research News and Information

Monday, November 23, 2009

Depression and cognitive complaints following mild traumatic brain injury.

30 May 2009 Traumatic brain injury (TBI) is a common occurrence with multiple possible neuropsychiatric sequelae, including problems with cognition, emotion, and behavior. While many individuals experience significant improvement over the first months following ... Read more...

Muscarinic agonists for the treatment of cognition in schizophrenia.

30 Oct 2008 It is widely accepted that cholinergic activity at muscarinic receptors is required to maintain cognitive functions, including learning and memory. Memory domains are especially impaired in schizophrenia, which may explain difficulties in ... Read more...

Activity and subcellular trafficking of the sodium-coupled choline transporter CHT is regulated acutely by peroxynitrite.

28 Oct 2007 Excess formation of nitric oxide and superoxide by-products (peroxynitrite, reactive oxygen, and reactive nitrogen species) attenuates cholinergic transmission potentially having a role in Alzheimer disease pathogenesis. In this study, we ... Read more...

Latest indexed articles for 'Choline - Antagonists & inhibitors'

These are the very latest articles for this heading:

• Depression and cognitive complaints following mild traumatic brain injury. 30 May 2009
• Muscarinic agonists for the treatment of cognition in schizophrenia. 30 Oct 2008
• Activity and subcellular trafficking of the sodium-coupled choline transporter CHT is regulated acutely by peroxynitrite. 28 Oct 2007
• Inhibition of choline transport by redox-active cholinomimetic bis-catechol reagents. 20 Aug 2007
• Molecular and functional characterization of an Na+-independent choline transporter in rat astrocytes. 3 Jul 2005
• Classification of the mode of inhibition of high-affinity choline uptake using capillary electrophoresis with electrochemical detection at an enzyme-modified microelectrode. 13 Apr 2005
• Low molecular weight glycosaminoglycan C3 attenuates AF64A-stimulated, low-affinity nerve growth factor receptor-immunoreactive axonal varicosities in the rat septum. 30 Jan 2005
• Novel analogs of choline as potential neuroprotective agents. 29 Nov 2004
• Permeability of human jejunal segments to gonyautoxins measured by the Ussing chamber technique. 29 Sep 2004
• Development of subtype-selective ligands as antagonists at nicotinic receptors mediating nicotine-evoked dopamine release. 17 Apr 2004
• Protection against inflammatory neurodegeneration and glial cell death by 7beta-hydroxy epiandrosterone, a novel neurosteroid. 28 Feb 2004
• Role of alpha7 nicotinic acetylcholine receptors in the pressor response to intracerebroventricular injection of choline: blockade by amyloid peptide Abeta1-42. 17 Feb 2004
• Memory consolidation and reconsolidation of an inhibitory avoidance response in mice: effects of i.c.v. injections of hemicholinium-3. 30 Dec 2003
• Evaluation of the inhibition of choline uptake in synaptosomes by capillary electrophoresis with electrochemical detection. 30 Oct 2002
• Inhibitors of choline uptake and metabolism cause developmental abnormalities in neurulating mouse embryos. 30 Jul 2001
• Central injection of captopril inhibits the blood pressure response to intracerebroventricular choline. 30 May 2001
• Paraoxon sensitive phenylvalerate hydrolase in assessing the severity of acute paraoxon poisoning. 30 Dec 2000
• Crotoxin, the major toxin from the rattlesnake Crotalus durissus terrificus, inhibits 3H-choline uptake in guinea pig ileum. 30 Aug 2000
• [K+ channel modulators] 30 Mar 2000
• [Quantitative evaluation of the role of cholinergic, gastrin, and histamine regulation of pepsinogen production in the stomach of anesthesized rats] 30 Dec 1999

See a longer list of these articles.

Technical information about 'Choline'

Definition: A basic constituent of lecithin that is found in many plants and animal organs. It is important as a precursor of acetylcholine, as a methyl donor in various metabolic processes, and in lipid metabolism.

Chemical name: Ethanaminium, 2-hydroxy-N,N,N-trimethyl-

Registry Number: 62-49-7

Descriptor UI: D002794

Alternative terms: Choline; 2-Hydroxy-N,N,N-trimethylethanaminium; Choline O-Sulfate; Choline O Sulfate; O-Sulfate, Choline; Choline Chloride; Chloride, Choline; Choline Citrate; Citrate, Choline; Bursine; Vidine; Fagine; Choline Bitartrate; Bitartrate, Choline;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: Lipotropic Agents; Nootropic Agents;

Tree Number: D02.033.100.291.211; D02.092.063.291.211; D02.092.877.883.333; D02.675.276.232;

Technical Notes: /biosyn /physiol permitted