Cholinergic Agents
Research News and Information

Sunday, November 22, 2009

Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system.

30 Aug 2009 Nicotinic receptors - a family of ligand-gated ion channels that mediate the effects of the neurotransmitter acetylcholine - are among the most well understood allosteric membrane proteins from a structural and functional perspective. There is also ... Read more...

Targets, receptors and effects of muscarinic neuromodulation on giant neurones of the rat dorsal cochlear nucleus.

25 Aug 2009 Although cholinergic modulation of the cochlear nucleus (CN) is functionally important, neither its cellular consequences nor the types of receptors conveying it are precisely known. The aim of this work was to characterise the cholinergic effects ... Read more...

A hydrosoluble triphenylene that preferentially binds acetylcholine, epibatidine, and nicotine.

15 Jul 2009 Synthesis and binding properties of a new hydrosoluble triphenylene 1b are reported. Selective recognition of acetylcholine (ACh) against other aliphatic ammoniums is achieved by this flat receptor, which also forms complexes with epibatidine and ... Read more...

Latest indexed articles for 'Cholinergic Agents'

These are the very latest articles for this heading:

• Factors influencing variability in clinical outcomes from imidacloprid self-poisoning. 30 Aug 2009
• Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system. 30 Aug 2009
• Targets, receptors and effects of muscarinic neuromodulation on giant neurones of the rat dorsal cochlear nucleus. 25 Aug 2009
• A hydrosoluble triphenylene that preferentially binds acetylcholine, epibatidine, and nicotine. 15 Jul 2009
• Phytochemical analyses and gastroprotective effects of Eugenia umbelliflora (Myrtaceae) on experimental gastric ulcers. 29 Jun 2009
• Nicotinic acetylcholine receptors as therapeutic targets: emerging frontiers in basic research and clinical science--editorial perspective. 29 Jun 2009
• A novel gel based vehicle for the delivery of acetylcholine in quantitative sudomotor axon reflex testing. 8 Jun 2009
• Pharmacological analysis of tonic activity in motoneurons during stick insect walking. 8 Jun 2009
• Effects of amphetamine on salivary secretion. 30 May 2009
• [The cholinergic non-excitability phenomenon in the atrial myocardium of lower vertebrates] 30 May 2009
• Kinetics of desensitization and recovery from desensitization for human alpha4beta2-nicotinic acetylcholine receptors stably expressed in SH-EP1 cells. 30 May 2009
• Cholinergic control of inflammation. 30 May 2009
• Retinoic acid prevents virus-induced airway hyperreactivity and M2 receptor dysfunction via anti-inflammatory and antiviral effects. 20 May 2009
• Constitutive expression of the alpha10 nicotinic acetylcholine receptor subunit fails to maintain cholinergic responses in inner hair cells after the onset of hearing. 17 May 2009
• Food allergy alters jejunal circular muscle contractility and induces local inflammatory cytokine expression in a mouse model. 16 May 2009
• Mechanisms of stretch-induced atrial fibrillation in the presence and the absence of adrenocholinergic stimulation: interplay between rotors and focal discharges. 12 May 2009
• Role of SREBP-1 in the development of parasympathetic dysfunction in the hearts of type 1 diabetic Akita mice. 5 May 2009
• The basal forebrain cholinergic system is required specifically for behaviorally mediated cortical map plasticity. 4 May 2009
• Tacrine-melatonin hybrids as multifunctional agents for Alzheimer's disease, with cholinergic, antioxidant, and neuroprotective properties. 29 Apr 2009
• Differentiating COPD from asthma in clinical practice. 29 Apr 2009

See a longer list of these articles.

Technical information about 'Cholinergic Agents'

Definition: Any drug used for its actions on cholinergic systems. Included here are agonists and antagonists, drugs that affect the life cycle of ACETYLCHOLINE, and drugs that affect the survival of cholinergic neurons. The term cholinergic agents is sometimes still used in the narrower sense of MUSCARINIC AGONISTS, although most modern texts discourage that usage.

Registry Number: 0

Descriptor UI: D018678

Alternative terms: Cholinergic Agents; Agents, Cholinergic; Cholinergic Drugs; Drugs, Cholinergic; Cholinergics; Acetylcholine Agents; Agents, Acetylcholine; Muscarinic Agents; Agents, Muscarinic; Muscarinics; Nicotinic Agents; Agents, Nicotinic; Cholinomimetics;

Related Mesh Headings: Botulinum Toxins; Bungarotoxins;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications;

Tree Number: D27.505.519.625.120; D27.505.696.577.120;

Online Note: use PARASYMPATHOMIMETICS to search CHOLINERGIC AGENTS 1975-94, CHOLINOMIMETICS 1974-94, & MUSCARINIC AGENTS 1969-94; use GANGLIONIC STIMULANTS to search NICOTINIC AGENTS 1978-94

History Note: 95; was see PARASYMPATHOMIMETICS 1975-94; NICOTINIC AGENTS was see GANGLIONIC STIMULANTS 1978-94; CHOLINOMIMETICS was see PARASYMPATHOMIMETICS 1974-94; MUSCARINIC AGENTS was see PARASYMPATHOMIMETICS 1969-94

Technical Notes: GEN or unspecified; prefer specifics