Cholinesterase Inhibitors - Chemistry
Research News and Information

Sunday, November 22, 2009

Acetylcholinesterase inhibitive activity-guided isolation of two new alkaloids from seeds of Peganum nigellastrum Bunge by an in vitro TLC- bioautographic assay.

24 Sep 2009 Acetylcholinesterase inhibitors (AChEIs) currently form the basis of the newest drugs available for the treatment of Alzheimer's disease. For the aim of screening effective AChEIs, the methanol extracts of the seeds of genus Peganum were found to ... Read more...

Pyrano[3,2-c]quinoline-6-chlorotacrine hybrids as a novel family of acetylcholinesterase- and beta-amyloid-directed anti-Alzheimer compounds.

8 Sep 2009 Two isomeric series of dual binding site acetylcholinesterase (AChE) inhibitors have been designed, synthesized, and tested for their ability to inhibit AChE, butyrylcholinesterase, AChE-induced and self-induced beta-amyloid (Abeta) aggregation, and ... Read more...

A fluorescence "turn-on" ensemble for acetylcholinesterase activity assay and inhibitor screening.

Sep 2009 By making use of the aggregation-induced emission feature of compound 1 and the cascade reactions among acetylthiocholine iodide (ATC), AChE, and compound 2, a new fluorescence "turn-on" method is developed for AChE assay and ... Read more...

Latest indexed articles for 'Cholinesterase Inhibitors - Chemistry'

These are the very latest articles for this heading:

• Acetylcholinesterase inhibitive activity-guided isolation of two new alkaloids from seeds of Peganum nigellastrum Bunge by an in vitro TLC- bioautographic assay. 24 Sep 2009
• Pyrano[3,2-c]quinoline-6-chlorotacrine hybrids as a novel family of acetylcholinesterase- and beta-amyloid-directed anti-Alzheimer compounds. 8 Sep 2009
• A fluorescence "turn-on" ensemble for acetylcholinesterase activity assay and inhibitor screening. Sep 2009
• An evaluation of the inhibition of human butyrylcholinesterase and acetylcholinesterase by the organophosphate chlorpyrifos oxon. 17 Aug 2009
• Stereoisomeric separation and bioassay of a new organophosphorus compound, O,S-dimethyl-N-(2,2,2-trichloro-1-methoxyethyl)phosphoramidothioate: some implications for chiral switch. 10 Aug 2009
• Clinical investigation of neuraxially administered drugs: a regulatory perspective. 30 Jul 2009
• Site-activated multifunctional chelator with acetylcholinesterase and neuroprotective-neurorestorative moieties for Alzheimer's therapy. 21 Jul 2009
• Comparing the inhibitory effects of five protoxicant organophosphates (azinphos-methyl, parathion-methyl, chlorpyriphos-methyl, methamidophos and diazinon) on the spontaneously beating auricle of Sparus aurata: an in vitro study. 14 Jul 2009
• Recombinant expression and biochemical characterization of the catalytic domain of acetylcholinesterase-1 from the African malaria mosquito, Anopheles gambiae. 12 Jul 2009
• Novel 16-substituted bifunctional derivatives of huperzine B: multifunctional cholinesterase inhibitors. 4 Jul 2009
• Development of a bioactive paper sensor for detection of neurotoxins using piezoelectric inkjet printing of sol-gel-derived bioinks. 29 Jun 2009
• Thiourea-catalyzed highly enantio- and diastereoselective additions of oxindoles to nitroolefins: application to the formal synthesis of (+)-physostigmine. 29 Jun 2009
• Adsorption and inhibition of acetylcholinesterase by different nanoparticles. 19 Jun 2009
• Boerhaavia diffusa: metabolite profiling of a medicinal plant from Nyctaginaceae. 11 Jun 2009
• Structure-activity analysis of aging and reactivation of human butyrylcholinesterase inhibited by analogues of tabun. 10 Jun 2009
• Research into selective biomarkers of erythrocyte exposure to organophosphorus compounds. 31 May 2009
• Acetylcholinesterase inhibition and antioxidant activity of essential oils from Schinus areira L. and Schinus longifolia (Lindl.) Speg. 30 May 2009
• Consensus superiority of the pharmacophore-based alignment, over maximum common substructure (MCS): 3D-QSAR studies on carbamates as acetylcholinesterase inhibitors. 30 May 2009
• Pyrrolidinoindoline alkaloids from Selaginella moellendorfii. 30 May 2009
• Development of square wave voltammetry method for the assessment of organophosphorus compound impact on the cholinesterase of Pheretima with 2,6-dichloroindophenol as a redox indicator. 29 May 2009

See a longer list of these articles.

Technical information about 'Cholinesterase Inhibitors'

Definition: Drugs that inhibit cholinesterases. The neurotransmitter ACETYLCHOLINE is rapidly hydrolyzed, and thereby inactivated, by cholinesterases. When cholinesterases are inhibited, the action of endogenously released acetylcholine at cholinergic synapses is potentiated. Cholinesterase inhibitors are widely used clinically for their potentiation of cholinergic inputs to the gastrointestinal tract and urinary bladder, the eye, and skeletal muscles; they are also used for their effects on the heart and the central nervous system.

Registry Number: 0

Descriptor UI: D002800

Alternative terms: Cholinesterase Inhibitors; Inhibitors, Cholinesterase; Anticholinesterase Drugs; Drugs, Anticholinesterase; Anticholinesterases; Anticholinesterase Agents; Agents, Anticholinesterase; Anti-Cholinesterases; Anti Cholinesterases; Cholinesterase Inhibitors, Irreversible; Inhibitors, Irreversible Cholinesterase; Irreversible Cholinesterase Inhibitors; Cholinesterase Inhibitors, Reversible; Inhibitors, Reversible Cholinesterase; Reversible Cholinesterase Inhibitors; Acetylcholinesterase Inhibitors; Inhibitors, Acetylcholinesterase;

Related Mesh Headings: Insecticides;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications;

Tree Number: D27.505.519.389.275; D27.505.519.625.120.300; D27.505.696.577.120.300;

Online Note: use CHOLINESTERASE INHIBITORS to search CHOLINESTERASE INHIBITORS, IRREVERSIBLE & CHOLINESTERASE INHIBITORS, REVERSIBLE 1971-83 (as Prov 1971-74)

History Note: 65; CHOLINESTERASE INHIBITORS, IRREVERSIBLE & CHOLINESTERASE INHIBITORS, REVERSIBLE were see under CHOLINESTERASE INHIBITORS 1975-83, were Prov 1971-74; CHOLINESTERASE INHIBITORS, ORGANIC was see PHOSPHORUS POISONS, ORGANIC 1963-64 (PHOSPHORUS POISONS, ORGANIC deleted 1965)

Technical Notes: DF: CHOLINESTERASE INHIB