Cholinesterase Inhibitors - Isolation & purification
Research News and Information

Saturday, November 21, 2009

Acetylcholinesterase inhibitive activity-guided isolation of two new alkaloids from seeds of Peganum nigellastrum Bunge by an in vitro TLC- bioautographic assay.

24 Sep 2009 Acetylcholinesterase inhibitors (AChEIs) currently form the basis of the newest drugs available for the treatment of Alzheimer's disease. For the aim of screening effective AChEIs, the methanol extracts of the seeds of genus Peganum were found to ... Read more...

Pyrrolidinoindoline alkaloids from Selaginella moellendorfii.

30 May 2009 Eight new pyrrolidinoindoline alkaloids (1-8) were isolated from the whole plant of Selaginella moellendorfii. Their structures were determined by mass spectrometry, 1D and 2D NMR spectroscopy, and chemical interconversions. These alkaloids have a ... Read more...

Cognitive-enhancing activity of loganin isolated from Cornus officinalis in scopolamine-induced amnesic mice.

25 May 2009 We examined anti-amnesic activity of the methanolic extract of Cornus officinalis fruits (COT) and a major constituent, loganin using scopolamine-induced (1 mg/kg body weight, s.c.) amnesic mice with both passive avoidance and the Morris water maze ... Read more...

Latest indexed articles for 'Cholinesterase Inhibitors - Isolation & purification'

These are the very latest articles for this heading:

• Acetylcholinesterase inhibitive activity-guided isolation of two new alkaloids from seeds of Peganum nigellastrum Bunge by an in vitro TLC- bioautographic assay. 24 Sep 2009
• Pyrrolidinoindoline alkaloids from Selaginella moellendorfii. 30 May 2009
• Cognitive-enhancing activity of loganin isolated from Cornus officinalis in scopolamine-induced amnesic mice. 25 May 2009
• Inhibitory effect of Poncirus trifoliate on acetylcholinesterase and attenuating activity against trimethyltin-induced learning and memory impairment. 5 May 2009
• Serratezomines D and E, new Lycopodium alkaloids from Lycopodium serratum var. serratum. 3 May 2009
• Acetylcholinesterase and butyrylcholinesterase inhibition of ethanolic extract and monoterpenes from Pimpinella anisoides V Brig. (Apiaceae). 3 Apr 2009
• New diterpenoid alkaloids from Aconitum heterophyllum Wall: Selective butyrylcholinestrase inhibitors. 30 Jan 2009
• Cholinesterase inhibitors from Sargassum and Gracilaria gracilis: seaweeds inhabiting South Indian coastal areas (Hare Island, Gulf of Mannar). 30 Dec 2008
• Triclisia sacleuxii (Pierre) Diels (Menispermaceae), a potential source of acetylcholinesterase inhibitors. 30 Dec 2008
• In silico target fishing for rationalized ligand discovery exemplified on constituents of Ruta graveolens. 16 Dec 2008
• Pressurized liquid extraction and anticholinesterase activity-based thin-layer chromatography with bioautography of Amaryllidaceae alkaloids. 28 Nov 2008
• Acetylcholinesterase inhibitory guided fractionation of Melissa officinalis L. 18 Nov 2008
• Inhibition of acetylcholinesterase activity by dihydro-beta-agarofuran sesquiterpenes isolated from Chilean Celastraceae. 30 Oct 2008
• A new stilbene glucoside gallate from the roots of Polygonum multiflorum. 27 Oct 2008
• Acetylcholinesterase-inhibiting activity of pyrrole derivatives from a novel marine gliding bacterium, Rapidithrix thailandica. 11 Oct 2008
• Immobilized butyrylcholinesterase in the characterization of new inhibitors that could ease Alzheimer's disease. 2 Oct 2008
• New butyrylcholinesterase inhibitory steroid and peroxy acid from Leucas urticifolia. 10 Sep 2008
• Two fast screening methods (GC-MS and TLC-ChEI assay) for rapid evaluation of potential anticholinesterasic indole alkaloids in complex mixtures. 30 Aug 2008
• Chromatographic resolution, characterisation and quantification of VX enantiomers in hemolysed swine blood samples. 4 Aug 2008
• Bioactive 5alpha-pregnane-type steroidal alkaloids from Sarcococca hookeriana. 4 Aug 2008

See a longer list of these articles.

Technical information about 'Cholinesterase Inhibitors'

Definition: Drugs that inhibit cholinesterases. The neurotransmitter ACETYLCHOLINE is rapidly hydrolyzed, and thereby inactivated, by cholinesterases. When cholinesterases are inhibited, the action of endogenously released acetylcholine at cholinergic synapses is potentiated. Cholinesterase inhibitors are widely used clinically for their potentiation of cholinergic inputs to the gastrointestinal tract and urinary bladder, the eye, and skeletal muscles; they are also used for their effects on the heart and the central nervous system.

Registry Number: 0

Descriptor UI: D002800

Alternative terms: Cholinesterase Inhibitors; Inhibitors, Cholinesterase; Anticholinesterase Drugs; Drugs, Anticholinesterase; Anticholinesterases; Anticholinesterase Agents; Agents, Anticholinesterase; Anti-Cholinesterases; Anti Cholinesterases; Cholinesterase Inhibitors, Irreversible; Inhibitors, Irreversible Cholinesterase; Irreversible Cholinesterase Inhibitors; Cholinesterase Inhibitors, Reversible; Inhibitors, Reversible Cholinesterase; Reversible Cholinesterase Inhibitors; Acetylcholinesterase Inhibitors; Inhibitors, Acetylcholinesterase;

Related Mesh Headings: Insecticides;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications;

Tree Number: D27.505.519.389.275; D27.505.519.625.120.300; D27.505.696.577.120.300;

Online Note: use CHOLINESTERASE INHIBITORS to search CHOLINESTERASE INHIBITORS, IRREVERSIBLE & CHOLINESTERASE INHIBITORS, REVERSIBLE 1971-83 (as Prov 1971-74)

History Note: 65; CHOLINESTERASE INHIBITORS, IRREVERSIBLE & CHOLINESTERASE INHIBITORS, REVERSIBLE were see under CHOLINESTERASE INHIBITORS 1975-83, were Prov 1971-74; CHOLINESTERASE INHIBITORS, ORGANIC was see PHOSPHORUS POISONS, ORGANIC 1963-64 (PHOSPHORUS POISONS, ORGANIC deleted 1965)

Technical Notes: DF: CHOLINESTERASE INHIB