Cholinesterase Inhibitors - Pharmacology
Research News and Information

Saturday, November 21, 2009

Acetylcholinesterase inhibitive activity-guided isolation of two new alkaloids from seeds of Peganum nigellastrum Bunge by an in vitro TLC- bioautographic assay.

24 Sep 2009 Acetylcholinesterase inhibitors (AChEIs) currently form the basis of the newest drugs available for the treatment of Alzheimer's disease. For the aim of screening effective AChEIs, the methanol extracts of the seeds of genus Peganum were found to ... Read more...

Pyrano[3,2-c]quinoline-6-chlorotacrine hybrids as a novel family of acetylcholinesterase- and beta-amyloid-directed anti-Alzheimer compounds.

8 Sep 2009 Two isomeric series of dual binding site acetylcholinesterase (AChE) inhibitors have been designed, synthesized, and tested for their ability to inhibit AChE, butyrylcholinesterase, AChE-induced and self-induced beta-amyloid (Abeta) aggregation, and ... Read more...

A fluorescence "turn-on" ensemble for acetylcholinesterase activity assay and inhibitor screening.

Sep 2009 By making use of the aggregation-induced emission feature of compound 1 and the cascade reactions among acetylthiocholine iodide (ATC), AChE, and compound 2, a new fluorescence "turn-on" method is developed for AChE assay and ... Read more...

Latest indexed articles for 'Cholinesterase Inhibitors - Pharmacology'

These are the very latest articles for this heading:

• Acetylcholinesterase inhibitive activity-guided isolation of two new alkaloids from seeds of Peganum nigellastrum Bunge by an in vitro TLC- bioautographic assay. 24 Sep 2009
• Pyrano[3,2-c]quinoline-6-chlorotacrine hybrids as a novel family of acetylcholinesterase- and beta-amyloid-directed anti-Alzheimer compounds. 8 Sep 2009
• A fluorescence "turn-on" ensemble for acetylcholinesterase activity assay and inhibitor screening. Sep 2009
• Retrospective population pharmacokinetic/pharmacodynamic analysis of pyridostigmine, a cholinesterase inhibitor, in Chinese males. 30 Aug 2009
• Physostigmine-induced hypothermic response in rats and its relationship with endogenous arginine vasopressin. 29 Aug 2009
• Studies on the influence of esterase inhibitor to the pharmacokinetic profiles of oseltamivir and oseltamivir carboxylate in rats using an improved LC/MS/MS method. 30 Jul 2009
• Green tea polyphenol (-)-epigallocatechin-3-gallate enhances the inhibitory effect of huperzine A on acetylcholinesterase by increasing the affinity with serum albumin. 30 Jul 2009
• Acute cognitive effects of donepezil in young, healthy volunteers. 30 Jul 2009
• Donepezil improves episodic memory in young individuals vulnerable to the effects of sleep deprivation. 30 Jul 2009
• Update on neuromuscular pharmacology. 30 Jul 2009
• Progression from mild cognitive impairment to Alzheimer's disease: effects of sex, butyrylcholinesterase genotype, and rivastigmine treatment. 30 Jul 2009
• Galantamine is a novel post-exposure therapeutic against lethal VX challenge. 28 Jul 2009
• Site-activated multifunctional chelator with acetylcholinesterase and neuroprotective-neurorestorative moieties for Alzheimer's therapy. 21 Jul 2009
• Predicting inhibitors of acetylcholinesterase by regression and classification machine learning approaches with combinations of molecular descriptors. 13 Jul 2009
• Effects of galantamine on L-NAME-induced behavioral impairment in Y-maze task in mice. 13 Jul 2009
• The aryl acylamidase activity is much more sensitive to Alzheimer drugs than the esterase activity of acetylcholinesterase in chicken embryonic brain. 12 Jul 2009
• Cholinesterase inhibitory activities of some flavonoid derivatives and chosen xanthone and their molecular docking studies. 7 Jul 2009
• Novel 16-substituted bifunctional derivatives of huperzine B: multifunctional cholinesterase inhibitors. 4 Jul 2009
• Involvement of lipids in dimethoate-induced inhibition of testosterone biosynthesis in rat interstitial cells. 3 Jul 2009
• Development of semagacestat (LY450139), a functional gamma-secretase inhibitor, for the treatment of Alzheimer's disease. 29 Jun 2009

See a longer list of these articles.

Technical information about 'Cholinesterase Inhibitors'

Definition: Drugs that inhibit cholinesterases. The neurotransmitter ACETYLCHOLINE is rapidly hydrolyzed, and thereby inactivated, by cholinesterases. When cholinesterases are inhibited, the action of endogenously released acetylcholine at cholinergic synapses is potentiated. Cholinesterase inhibitors are widely used clinically for their potentiation of cholinergic inputs to the gastrointestinal tract and urinary bladder, the eye, and skeletal muscles; they are also used for their effects on the heart and the central nervous system.

Registry Number: 0

Descriptor UI: D002800

Alternative terms: Cholinesterase Inhibitors; Inhibitors, Cholinesterase; Anticholinesterase Drugs; Drugs, Anticholinesterase; Anticholinesterases; Anticholinesterase Agents; Agents, Anticholinesterase; Anti-Cholinesterases; Anti Cholinesterases; Cholinesterase Inhibitors, Irreversible; Inhibitors, Irreversible Cholinesterase; Irreversible Cholinesterase Inhibitors; Cholinesterase Inhibitors, Reversible; Inhibitors, Reversible Cholinesterase; Reversible Cholinesterase Inhibitors; Acetylcholinesterase Inhibitors; Inhibitors, Acetylcholinesterase;

Related Mesh Headings: Insecticides;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications;

Tree Number: D27.505.519.389.275; D27.505.519.625.120.300; D27.505.696.577.120.300;

Online Note: use CHOLINESTERASE INHIBITORS to search CHOLINESTERASE INHIBITORS, IRREVERSIBLE & CHOLINESTERASE INHIBITORS, REVERSIBLE 1971-83 (as Prov 1971-74)

History Note: 65; CHOLINESTERASE INHIBITORS, IRREVERSIBLE & CHOLINESTERASE INHIBITORS, REVERSIBLE were see under CHOLINESTERASE INHIBITORS 1975-83, were Prov 1971-74; CHOLINESTERASE INHIBITORS, ORGANIC was see PHOSPHORUS POISONS, ORGANIC 1963-64 (PHOSPHORUS POISONS, ORGANIC deleted 1965)

Technical Notes: DF: CHOLINESTERASE INHIB