Cholinesterase Inhibitors - Therapeutic use
Research News and Information

Sunday, November 22, 2009

Pyrano[3,2-c]quinoline-6-chlorotacrine hybrids as a novel family of acetylcholinesterase- and beta-amyloid-directed anti-Alzheimer compounds.

8 Sep 2009 Two isomeric series of dual binding site acetylcholinesterase (AChE) inhibitors have been designed, synthesized, and tested for their ability to inhibit AChE, butyrylcholinesterase, AChE-induced and self-induced beta-amyloid (Abeta) aggregation, and ... Read more...

Successful use of donepezil in treatment of cognitive impairment caused by maintenance electroconvulsive therapy: a case report.

30 Aug 2009 Cognitive deficits are commonly associated with maintenance electroconvulsive therapy (ECT). Treatment of these cognitive deficits is important but difficult. Cholinergic pathways are involved in these side effects, and donepezil, a cholinesterase ... Read more...

Current Alzheimer's disease clinical trials: methods and placebo outcomes.

30 Aug 2009 BACKGROUND: Eighteen-month-long randomized, placebo-controlled clinical trials are common for phase II and phase III drug development for Alzheimer's disease (AD). Yet, no 18-month trial has shown statistically significant outcomes favoring the test ... Read more...

Latest indexed articles for 'Cholinesterase Inhibitors - Therapeutic use'

These are the very latest articles for this heading:

• Donepezil treatment of patients with MCI: a 48-week randomized, placebo- controlled trial. Nov 2009
• Teaching NeuroImages: reversible ectropion in myasthenia gravis. 18 Oct 2009
• Adverse events in patients receiving cholinesterase inhibitors due to dissimilar follow-up periods. 10 Oct 2009
• Pyrano[3,2-c]quinoline-6-chlorotacrine hybrids as a novel family of acetylcholinesterase- and beta-amyloid-directed anti-Alzheimer compounds. 8 Sep 2009
• Successful use of donepezil in treatment of cognitive impairment caused by maintenance electroconvulsive therapy: a case report. 30 Aug 2009
• Current Alzheimer's disease clinical trials: methods and placebo outcomes. 30 Aug 2009
• The effects of counseling spouse caregivers of people with Alzheimer disease taking donepezil and of country of residence on rates of admission to nursing homes and mortality. 30 Aug 2009
• Atomoxetine augmentation of cholinesterase inhibitor therapy in patients with Alzheimer disease: 6-month, randomized, double-blind, placebo-controlled, parallel-trial study. 30 Aug 2009
• Brief psychosocial therapy for the treatment of agitation in Alzheimer disease (the CALM-AD trial). 30 Aug 2009
• Medication for dementia. 30 Aug 2009
• Can cognitive enhancers reduce the risk of falls in older people with mild cognitive impairment? A protocol for a randomised controlled double blind trial. 10 Aug 2009
• CHI's Eighth Annual World Pharmaceutical Congress. Targeting Alzheimer's with novel therapeutics: Part 2. 30 Jul 2009
• Changes in utilisation of anticholinergic drugs after initiation of cholinesterase inhibitors. 30 Jul 2009
• Smell identification test as a treatment response marker in patients with Alzheimer disease receiving donepezil. 30 Jul 2009
• How to manage overactive bladder in elderly individuals with dementia? A combined use of donepezil, a central acetylcholinesterase inhibitor, and propiverine, a peripheral muscarine receptor antagonist. 30 Jul 2009
• Epidural neostigmine: will it replace lipid soluble opioids for postoperative and labor analgesia? 30 Jul 2009
• Pharmacological treatment of apathy in neurodegenerative diseases: a systematic review. 15 Jul 2009
• A comparative analysis of sensory visual evoked oscillations with visual cognitive event related oscillations in Alzheimer's disease. 14 Jul 2009
• Acute colonic pseudo-obstruction (Ogilvie's syndrome): radiologic diagnosis and medical treatment with neostigmine. Report of 4 cases. 29 Jun 2009
• Development of semagacestat (LY450139), a functional gamma-secretase inhibitor, for the treatment of Alzheimer's disease. 29 Jun 2009

See a longer list of these articles.

Technical information about 'Cholinesterase Inhibitors'

Definition: Drugs that inhibit cholinesterases. The neurotransmitter ACETYLCHOLINE is rapidly hydrolyzed, and thereby inactivated, by cholinesterases. When cholinesterases are inhibited, the action of endogenously released acetylcholine at cholinergic synapses is potentiated. Cholinesterase inhibitors are widely used clinically for their potentiation of cholinergic inputs to the gastrointestinal tract and urinary bladder, the eye, and skeletal muscles; they are also used for their effects on the heart and the central nervous system.

Registry Number: 0

Descriptor UI: D002800

Alternative terms: Cholinesterase Inhibitors; Inhibitors, Cholinesterase; Anticholinesterase Drugs; Drugs, Anticholinesterase; Anticholinesterases; Anticholinesterase Agents; Agents, Anticholinesterase; Anti-Cholinesterases; Anti Cholinesterases; Cholinesterase Inhibitors, Irreversible; Inhibitors, Irreversible Cholinesterase; Irreversible Cholinesterase Inhibitors; Cholinesterase Inhibitors, Reversible; Inhibitors, Reversible Cholinesterase; Reversible Cholinesterase Inhibitors; Acetylcholinesterase Inhibitors; Inhibitors, Acetylcholinesterase;

Related Mesh Headings: Insecticides;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications;

Tree Number: D27.505.519.389.275; D27.505.519.625.120.300; D27.505.696.577.120.300;

Online Note: use CHOLINESTERASE INHIBITORS to search CHOLINESTERASE INHIBITORS, IRREVERSIBLE & CHOLINESTERASE INHIBITORS, REVERSIBLE 1971-83 (as Prov 1971-74)

History Note: 65; CHOLINESTERASE INHIBITORS, IRREVERSIBLE & CHOLINESTERASE INHIBITORS, REVERSIBLE were see under CHOLINESTERASE INHIBITORS 1975-83, were Prov 1971-74; CHOLINESTERASE INHIBITORS, ORGANIC was see PHOSPHORUS POISONS, ORGANIC 1963-64 (PHOSPHORUS POISONS, ORGANIC deleted 1965)

Technical Notes: DF: CHOLINESTERASE INHIB