Cholinesterase Inhibitors
Research News and Information

Saturday, November 21, 2009

Acetylcholinesterase inhibitive activity-guided isolation of two new alkaloids from seeds of Peganum nigellastrum Bunge by an in vitro TLC- bioautographic assay.

24 Sep 2009 Acetylcholinesterase inhibitors (AChEIs) currently form the basis of the newest drugs available for the treatment of Alzheimer's disease. For the aim of screening effective AChEIs, the methanol extracts of the seeds of genus Peganum were found to ... Read more...

Pyrano[3,2-c]quinoline-6-chlorotacrine hybrids as a novel family of acetylcholinesterase- and beta-amyloid-directed anti-Alzheimer compounds.

8 Sep 2009 Two isomeric series of dual binding site acetylcholinesterase (AChE) inhibitors have been designed, synthesized, and tested for their ability to inhibit AChE, butyrylcholinesterase, AChE-induced and self-induced beta-amyloid (Abeta) aggregation, and ... Read more...

A fluorescence "turn-on" ensemble for acetylcholinesterase activity assay and inhibitor screening.

Sep 2009 By making use of the aggregation-induced emission feature of compound 1 and the cascade reactions among acetylthiocholine iodide (ATC), AChE, and compound 2, a new fluorescence "turn-on" method is developed for AChE assay and ... Read more...

Latest indexed articles for 'Cholinesterase Inhibitors'

These are the very latest articles for this heading:

• Donepezil treatment of patients with MCI: a 48-week randomized, placebo- controlled trial. Nov 2009
• Teaching NeuroImages: reversible ectropion in myasthenia gravis. 18 Oct 2009
• Adverse events in patients receiving cholinesterase inhibitors due to dissimilar follow-up periods. 10 Oct 2009
• Case report: combined use of donepezil and galantamine in mixed dementia. 29 Sep 2009
• Acetylcholinesterase inhibitive activity-guided isolation of two new alkaloids from seeds of Peganum nigellastrum Bunge by an in vitro TLC- bioautographic assay. 24 Sep 2009
• Pyrano[3,2-c]quinoline-6-chlorotacrine hybrids as a novel family of acetylcholinesterase- and beta-amyloid-directed anti-Alzheimer compounds. 8 Sep 2009
• A fluorescence "turn-on" ensemble for acetylcholinesterase activity assay and inhibitor screening. Sep 2009
• Successful use of donepezil in treatment of cognitive impairment caused by maintenance electroconvulsive therapy: a case report. 30 Aug 2009
• Current Alzheimer's disease clinical trials: methods and placebo outcomes. 30 Aug 2009
• Retrospective population pharmacokinetic/pharmacodynamic analysis of pyridostigmine, a cholinesterase inhibitor, in Chinese males. 30 Aug 2009
• The effects of counseling spouse caregivers of people with Alzheimer disease taking donepezil and of country of residence on rates of admission to nursing homes and mortality. 30 Aug 2009
• Atomoxetine augmentation of cholinesterase inhibitor therapy in patients with Alzheimer disease: 6-month, randomized, double-blind, placebo-controlled, parallel-trial study. 30 Aug 2009
• Brief psychosocial therapy for the treatment of agitation in Alzheimer disease (the CALM-AD trial). 30 Aug 2009
• Obidoxime in acute organophosphate poisoning: 1 - clinical effectiveness. 30 Aug 2009
• Obidoxime in acute organophosphate poisoning: 2 - PK/PD relationships. 30 Aug 2009
• Medication for dementia. 30 Aug 2009
• Physostigmine-induced hypothermic response in rats and its relationship with endogenous arginine vasopressin. 29 Aug 2009
• An evaluation of the inhibition of human butyrylcholinesterase and acetylcholinesterase by the organophosphate chlorpyrifos oxon. 17 Aug 2009
• Stereoisomeric separation and bioassay of a new organophosphorus compound, O,S-dimethyl-N-(2,2,2-trichloro-1-methoxyethyl)phosphoramidothioate: some implications for chiral switch. 10 Aug 2009
• Can cognitive enhancers reduce the risk of falls in older people with mild cognitive impairment? A protocol for a randomised controlled double blind trial. 10 Aug 2009

See a longer list of these articles.

Technical information about 'Cholinesterase Inhibitors'

Definition: Drugs that inhibit cholinesterases. The neurotransmitter ACETYLCHOLINE is rapidly hydrolyzed, and thereby inactivated, by cholinesterases. When cholinesterases are inhibited, the action of endogenously released acetylcholine at cholinergic synapses is potentiated. Cholinesterase inhibitors are widely used clinically for their potentiation of cholinergic inputs to the gastrointestinal tract and urinary bladder, the eye, and skeletal muscles; they are also used for their effects on the heart and the central nervous system.

Registry Number: 0

Descriptor UI: D002800

Alternative terms: Cholinesterase Inhibitors; Inhibitors, Cholinesterase; Anticholinesterase Drugs; Drugs, Anticholinesterase; Anticholinesterases; Anticholinesterase Agents; Agents, Anticholinesterase; Anti-Cholinesterases; Anti Cholinesterases; Cholinesterase Inhibitors, Irreversible; Inhibitors, Irreversible Cholinesterase; Irreversible Cholinesterase Inhibitors; Cholinesterase Inhibitors, Reversible; Inhibitors, Reversible Cholinesterase; Reversible Cholinesterase Inhibitors; Acetylcholinesterase Inhibitors; Inhibitors, Acetylcholinesterase;

Related Mesh Headings: Insecticides;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications;

Tree Number: D27.505.519.389.275; D27.505.519.625.120.300; D27.505.696.577.120.300;

Online Note: use CHOLINESTERASE INHIBITORS to search CHOLINESTERASE INHIBITORS, IRREVERSIBLE & CHOLINESTERASE INHIBITORS, REVERSIBLE 1971-83 (as Prov 1971-74)

History Note: 65; CHOLINESTERASE INHIBITORS, IRREVERSIBLE & CHOLINESTERASE INHIBITORS, REVERSIBLE were see under CHOLINESTERASE INHIBITORS 1975-83, were Prov 1971-74; CHOLINESTERASE INHIBITORS, ORGANIC was see PHOSPHORUS POISONS, ORGANIC 1963-64 (PHOSPHORUS POISONS, ORGANIC deleted 1965)

Technical Notes: DF: CHOLINESTERASE INHIB