Chromatin - Drug effects
Research News and Information

Monday, November 23, 2009

Thalidomide alters nuclear architecture without ABCB1 gene modulation in drug-resistant myeloma cells.

30 Aug 2009 ABCB1 gene overexpression has been described as an important mechanism for resistance to conventional chemotherapy in multiple myelomas. In the refractory multiple myelomas, other drug regimens have been successfully applied, including thalidomide ... Read more...

ICAT as a potential enhancer of monocytic differentiation: implications from the comparative proteome analysis of the HL60 cell line stimulated by all-trans retinoic acid and NSC67657.

30 Jul 2009 A novel sterol mesylate compound (NSC67657) was recently identified and reported by National Cancer Institute that could efficiently induce the differentiation of HL60 cells into monocytes in vitro and in vivo. The expression of many proteins would ... Read more...

Realgar-mediated growth inhibition on HaCaT human keratinocytes is associated with induction of apoptosis.

30 Jul 2009 Traditional Chinese medicine has long been used to treat a variety of ailments including skin diseases. Our previous study has revealed the ethanolic extract of realgar, a common ingredient used in psoriasis treatment in Chinese medicine, to possess ... Read more...

Latest indexed articles for 'Chromatin - Drug effects'

These are the very latest articles for this heading:

• Thalidomide alters nuclear architecture without ABCB1 gene modulation in drug-resistant myeloma cells. 30 Aug 2009
• ICAT as a potential enhancer of monocytic differentiation: implications from the comparative proteome analysis of the HL60 cell line stimulated by all-trans retinoic acid and NSC67657. 30 Jul 2009
• Realgar-mediated growth inhibition on HaCaT human keratinocytes is associated with induction of apoptosis. 30 Jul 2009
• Erucylphospho-N,N,N-trimethylpropylammonium shows substantial cytotoxicity in multiple myeloma cells. 30 Jul 2009
• NV-128, a novel isoflavone derivative, induces caspase-independent cell death through the Akt/mammalian target of rapamycin pathway. 13 Jul 2009
• Post-activation treatment with demecolcine improves development of somatic cell nuclear transfer embryos in pigs by modifying the remodeling of donor nuclei. 29 Jun 2009
• Chromosome shattering: a mitotic catastrophe due to chromosome condensation failure. 16 Jun 2009
• Chicken HS4 insulator significantly improves baculovirus-mediated foreign gene expression in insect cells by modifying the structure of neighbouring chromatin in virus minichromosome. 15 Jun 2009
• Imipramine treatment and resiliency exhibit similar chromatin regulation in the mouse nucleus accumbens in depression models. 15 Jun 2009
• Epigenetics in cancer: targeting chromatin modifications. 7 Jun 2009
• Frequent loss of cystatin E/M expression implicated in the progression of prostate cancer. 6 Jun 2009
• Cylindrospermopsin induces alterations of root histology and microtubule organization in common reed (Phragmites australis) plantlets cultured in vitro. 19 May 2009
• Interaction of TFAP2C with the estrogen receptor-alpha promoter is controlled by chromatin structure. 17 May 2009
• Genome-wide analysis of chromatin regulation by cocaine reveals a role for sirtuins. 12 May 2009
• Lithium and neuropsychiatric therapeutics: neuroplasticity via glycogen synthase kinase-3beta, beta-catenin, and neurotrophin cascades. 6 May 2009
• Association between transcriptional activity, local chromatin structure, and the efficiencies of both subpathways of nucleotide excision repair of melphalan adducts. 3 May 2009
• Remodeling of chromatin structure within the promoter is important for bmp-2-induced fgfr3 expression. 26 Apr 2009
• The effect of vinca alkaloid anticancer drug, vinorelbine, on chromatin and histone proteins in solution. 22 Apr 2009
• A tale of tails: how histone tails mediate chromatin compaction in different salt and linker histone environments. 21 Apr 2009
• Calmodulin kinase II activation of mitogen-activated protein kinase in PC12 cell following all-trans retinoic acid treatment. 30 Mar 2009

See a longer list of these articles.

Technical information about 'Chromatin'

Definition: The material of CHROMOSOMES. It is a complex of DNA; HISTONES; and nonhistone proteins (CHROMOSOMAL PROTEINS, NON-HISTONE) found within the nucleus of a cell.

Registry Number: 0

Descriptor UI: D002843

Alternative terms: Chromatin; Chromatins;

Allowable Qualifiers: classification; drug effects; enzymology; immunology; metabolism; microbiology; parasitology; pathology; physiology; radiation effects; radiography; radionuclide imaging; secretion; transplantation; ultrastructure; ultrasonography; chemistry; virology; genetics; isolation & purification;

Tree Number: A11.284.430.106.279.345.190.160.180; D12.776.664.224; G05.360.160.180;

History Note: 72