Chromatography, High Pressure Liquid
Research News and Information

Saturday, November 21, 2009

Directed "in situ" inhibitor elongation as a strategy to structurally characterize the covalent glycosyl-enzyme intermediate of human pancreatic alpha-amylase.

15 Nov 2009 While covalent catalytic intermediates of retaining alpha-transglycosylases have been structurally characterized previously, no such information for a hydrolytic alpha-amylase has been obtained. This study presents a new "in situ" enzymatic ... Read more...

Antitumor activity of delimotecan against human metastatic melanoma: pharmacokinetics and molecular determinants.

13 Nov 2009 Delimotecan (MEN 4901/T-0128) is a new cytotoxic prodrug constituted by a camptothecin analog (T-2513) bound to carboxymethyl dextran through a triglycine linker. A significant antitumor activity of delimotecan against human metastatic melanoma ... Read more...

Biologically active sequences in the mouse laminin alpha3 chain G domain.

8 Nov 2009 The laminin alpha3 chain is mainly expressed at the skin, and its C-terminal G domain has a critical role in multiple biological functions. We screened for biologically active sites on the mouse laminin alpha3 chain G domain using 107 synthetic ... Read more...

Latest indexed articles for 'Chromatography, High Pressure Liquid'

These are the very latest articles for this heading:

• Directed "in situ" inhibitor elongation as a strategy to structurally characterize the covalent glycosyl-enzyme intermediate of human pancreatic alpha-amylase. 15 Nov 2009
• Antitumor activity of delimotecan against human metastatic melanoma: pharmacokinetics and molecular determinants. 13 Nov 2009
• Biologically active sequences in the mouse laminin alpha3 chain G domain. 8 Nov 2009
• The ATP-dependent amide ligases DdaG and DdaF assemble the fumaramoyl-dipeptide scaffold of the dapdiamide antibiotics. Nov 2009
• A flavin cofactor-binding PAS domain regulates c-di-GMP synthesis in AxDGC2 from Acetobacter xylinum. Nov 2009
• Mutual exchange of kinetic properties by extended mutagenesis in two short LOV domain proteins from Pseudomonas putida. Nov 2009
• Evaluation of N-benzyl-N-[11C]methyl-2- (7-methyl-8-oxo-2-phenyl-7,8-dihydro-9H-purin-9-yl)acetamide ([11C]DAC) as a novel translocator protein (18 kDa) radioligand in kainic acid-lesioned rat. 30 Oct 2009
• In vivo measurement of somatodendritic release of dopamine in the ventral tegmental area. 30 Oct 2009
• Hereditary multiple exostoses and juvenile colon carcinoma: A case with a common genetic background? 30 Oct 2009
• Depletion of selective serotonin reuptake inhibitors during sewage sludge composting. 30 Oct 2009
• Design of proteolytically stable RI-anchoring disruptor peptidomimetics for in vivo studies of anchored type I protein kinase A-mediated signalling. 21 Oct 2009
• The cis-(5R,6S)-thymine glycol lesion occupies the wobble position when mismatched with deoxyguanosine in DNA. 18 Oct 2009
• Transition state analogues rescue ribosomes from saporin-L1 ribosome inactivating protein. 18 Oct 2009
• Evaluation of monoclonal antibody and phenolic extraction from transgenic Lemna for purification process development. 13 Oct 2009
• Mimics of the self-assembling chlorosomal bacteriochlorophylls: regio- and stereoselective synthesis and stereoanalysis of acyl(1-hydroxyalkyl)porphyrins. 12 Oct 2009
• Altered myocardial substrate metabolism and decreased diastolic function in nonischemic human diabetic cardiomyopathy: studies with cardiac positron emission tomography and magnetic resonance imaging. 11 Oct 2009
• Two sampling time profiles for the abbreviated estimation of mycophenolic acid area under the curve in adult renal transplant recipients treated with mycophenolate mofetil and concomitant tacrolimus. 29 Sep 2009
• American ginseng berry enhances chemopreventive effect of 5-FU on human colorectal cancer cells. 29 Sep 2009
• In vitro anti-neoplastic activity of the ethno-pharmaceutical plant Hypericum adenotrichum Spach endemic to Western Turkey. 29 Sep 2009
• Comparison of the pharmacokinetics and pharmacodynamic profile of carumonam in cystic fibrosis patients and healthy volunteers. 29 Sep 2009

See a longer list of these articles.

Technical information about 'Chromatography, High Pressure Liquid'

Definition: Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.

Descriptor UI: D002851

Alternative terms: Chromatography, High Pressure Liquid; Chromatography, Liquid, High Pressure; HPLC; Chromatography, High Speed Liquid; Chromatography, High Performance Liquid;

Allowable Qualifiers: classification; economics; history; instrumentation; methods; standards; trends; utilization; veterinary; statistics & numerical data; ethics;

Tree Number: E05.196.181.400.300;

Online Note: use CHROMATOGRAPHY, HIGH PRESSURE LIQUID to search CHROMATOGRAPHY, HIGH SPEED LIQUID 1976-80

History Note: 81; was CHROMATOGRAPHY, HIGH SPEED LIQUID 1976-80

Technical Notes: an anal chem technique; NIM; DF: note short X ref