Circular Dichroism
Research News and Information

Sunday, November 22, 2009

Synthesis and evaluation of a novel class of G-quadruplex-stabilizing small molecules based on the 1,3-phenylene-bis(piperazinyl benzimidazole) system.

15 Nov 2009 Achieving stabilization of telomeric DNA in G-quadruplex conformation by various organic compounds has been an important goal for the medicinal chemists seeking to develop new anticancer agents. Several compounds are known to stabilize ... Read more...

Influence of aggregation propensity and stability on amyloid fibril formation as studied by Fourier transform infrared spectroscopy and two-dimensional COS analysis.

8 Nov 2009 Understanding the process of amyloidogenesis is important for the future treatment of misfolding-based diseases, such as Alzheimer's, spongiform encephalopathies, and other important disorders affecting humans. In this work, we have used one of the ... Read more...

Structure of chemokine-derived antimicrobial Peptide interleukin-8alpha and interaction with detergent micelles and oriented lipid bilayers.

8 Nov 2009 Interleukin-8alpha (IL-8alpha) is an antimicrobial peptide derived from the chemokine IL-8. Solution NMR was used to determine the atomic-resolution structure of IL-8alpha in SDS micelles. Solid-state NMR and tryptophan fluorescence were used to ... Read more...

Latest indexed articles for 'Circular Dichroism'

These are the very latest articles for this heading:

• Synthesis and evaluation of a novel class of G-quadruplex-stabilizing small molecules based on the 1,3-phenylene-bis(piperazinyl benzimidazole) system. 15 Nov 2009
• Influence of aggregation propensity and stability on amyloid fibril formation as studied by Fourier transform infrared spectroscopy and two-dimensional COS analysis. 8 Nov 2009
• Structure of chemokine-derived antimicrobial Peptide interleukin-8alpha and interaction with detergent micelles and oriented lipid bilayers. 8 Nov 2009
• Requirement of a unique Ca(2+)-binding loop for folding of Tk-subtilisin from a hyperthermophilic archaeon. 8 Nov 2009
• The SufBCD Fe-S scaffold complex interacts with SufA for Fe-S cluster transfer. 8 Nov 2009
• A novel domain in translational GTPase BipA mediates interaction with the 70S ribosome and influences GTP hydrolysis. 8 Nov 2009
• Interactions of the acidic domain and SRF interacting motifs with the NKX3.1 homeodomain. 8 Nov 2009
• Solution structure and functional characterization of human plasminogen kringle 5. Nov 2009
• Role of tryptophan-tryptophan interactions in Trpzip beta-hairpin formation, structure, and stability. Nov 2009
• Biophysical characterization of Chlamydia trachomatis CT584 supports its potential role as a type III secretion needle tip protein. Nov 2009
• EIN2, the central regulator of ethylene signalling, is localized at the ER membrane where it interacts with the ethylene receptor ETR1. 21 Oct 2009
• Effects of pH on the Rieske protein from Thermus thermophilus: a spectroscopic and structural analysis. 18 Oct 2009
• Comprehensive secondary-structure analysis of disulfide variants of lysozyme by synchrotron-radiation vacuum-ultraviolet circular dichroism. 29 Sep 2009
• Identification of trypsin-inhibitory site and structure determination of human SPINK2 serine proteinase inhibitor. 29 Sep 2009
• In vitro study of damaging effects of 2,4-dichlorophenoxyacetic acid on DNA structure by spectroscopic and voltammetric techniques. 29 Sep 2009
• Specific DNA G-quadruplexes bind to ethanolamines. 29 Sep 2009
• N-terminal truncated pyroglutamyl beta amyloid peptide Abetapy3-42 shows a faster aggregation kinetics than the full-length Abeta1-42. 29 Sep 2009
• Membrane-induced conformational change of alpha1-acid glycoprotein characterized by vacuum-ultraviolet circular dichroism spectroscopy. 27 Sep 2009
• Evaluation of copper2+ affinities for the prion protein. 27 Sep 2009
• De novo molecular modeling and biophysical characterization of Manduca sexta eclosion hormone. 27 Sep 2009

See a longer list of these articles.

Technical information about 'Circular Dichroism'

Definition: A change from planar to elliptic polarization when an initially plane-polarized light wave traverses an optically active medium. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)

Descriptor UI: D002942

Alternative terms: Circular Dichroism; Dichroism, Circular; Circular Dichroism, Vibrational; Vibrational Circular Dichroism;

Allowable Qualifiers: classification; economics; history; instrumentation; methods; standards; trends; utilization; veterinary; statistics & numerical data; ethics;

Tree Number: E05.196.867.151;

History Note: 91(70); was see under SPECTRUM ANALYSIS 1970-90