Citric Acid Cycle - Drug effects
Research News and Information

Monday, November 23, 2009

Experimental evidence that ornithine and homocitrulline disrupt energy metabolism in brain of young rats.

14 Jul 2009 Tissue accumulation of ornithine (Orn), homocitrulline (Hcit), ammonia and orotic acid (Oro) is the biochemical hallmark of patients affected by hyperornithinemia-hyperammonemia-homocitrullinuria (HHH) syndrome, a disorder clinically characterized ... Read more...

Dietary Ascophyllum nodosum increases urinary excretion of tricarboxylic acid cycle intermediates in male Sprague-dawley rats.

15 Jun 2009 We used a (1)H NMR-based metabonomics approach to examine the physiological effects of the seaweed Ascophyllum nodosum in a mammalian model, assess the dosage level required to elicit a response in the urinary profile, and identify potential toxic ... Read more...

Palladium alpha-lipoic acid complex formulation enhances activities of Krebs cycle dehydrogenases and respiratory complexes I-IV in the heart of aged rats.

11 Jun 2009 Age-related decline in the capacity to withstand stress, such as ischemia and reperfusion, results in congestive heart failure. Though the mechanisms underlying cardiac decay are not clear, age dependent somatic damages to mitochondrial DNA (mtDNA), ... Read more...

Latest indexed articles for 'Citric Acid Cycle - Drug effects'

These are the very latest articles for this heading:

• Experimental evidence that ornithine and homocitrulline disrupt energy metabolism in brain of young rats. 14 Jul 2009
• Dietary Ascophyllum nodosum increases urinary excretion of tricarboxylic acid cycle intermediates in male Sprague-dawley rats. 15 Jun 2009
• Palladium alpha-lipoic acid complex formulation enhances activities of Krebs cycle dehydrogenases and respiratory complexes I-IV in the heart of aged rats. 11 Jun 2009
• Effect of changes in fat availability on exercise capacity in McArdle disease. 30 May 2009
• Rescue of Abeta(1-42)-induced memory impairment in day-old chick by facilitation of astrocytic oxidative metabolism: implications for Alzheimer's disease. 29 Apr 2009
• Cross-talk between type three secretion system and metabolism in Yersinia. 23 Feb 2009
• Creatine administration prevents Na+,K+-ATPase inhibition induced by intracerebroventricular administration of isovaleric acid in cerebral cortex of young rats. 11 Jan 2009
• Untargeted metabolomic profiling as an evaluative tool of fenofibrate-induced toxicology in Fischer 344 male rats. 30 Dec 2008
• Effects of an alfalfa protein hydrolysate on the gene expression and activity of enzymes of the tricarboxylic acid (TCA) cycle and nitrogen metabolism in Zea mays L. 22 Dec 2008
• Antioxidant effect of ethyl pyruvate in respiring neonatal cerebrocortical slices after H(2)O(2) stress. 6 Nov 2008
• A target based therapeutic approach towards diabetes mellitus using medicinal plants. 30 Oct 2008
• Modulation of tricarboxylic acid cycle dehydrogenases during hepatocarcinogenesis induced by hexachlorocyclohexane in mice. 29 Oct 2008
• Targeting aspartate aminotransferase in breast cancer. 13 Oct 2008
• Robust glycogen shunt activity in astrocytes: Effects of glutamatergic and adrenergic agents. 12 Oct 2008
• Effect of FeSO4 treatment on glucose metabolism in diabetic rats. 5 Aug 2008
• Long-term effects of corticosterone on behavior, oxidative and energy metabolism of parietotemporal cerebral cortex and hippocampus of rats: comparison to intracerebroventricular streptozotocin. 3 Aug 2008
• Effect of carnitine on cutaneous wound healing in immunosuppressed rats. 9 Jul 2008
• Domoic acid impairment of cardiac energetics. 29 Jun 2008
• Effect of mangiferin on benzo(a)pyrene induced lung carcinogenesis in experimental Swiss albino mice. 18 May 2008
• Proteomic and metabolomic analyses of the white-rot fungus Phanerochaete chrysosporium exposed to exogenous benzoic acid. 23 Apr 2008

See a longer list of these articles.

Technical information about 'Citric Acid Cycle'

Definition: A series of oxidative reactions in the breakdown of acetyl units derived from GLUCOSE; FATTY ACIDS; or AMINO ACIDS by means of tricarboxylic acid intermediates. The end products are CARBON DIOXIDE, water, and energy in the form of phosphate bonds.

Descriptor UI: D002952

Alternative terms: Citric Acid Cycle; Citric Acid Cycles; Cycle, Citric Acid; Cycles, Citric Acid; Tricarboxylic Acid Cycle; Cycle, Tricarboxylic Acid; Cycles, Tricarboxylic Acid; Tricarboxylic Acid Cycles; Krebs Cycle; Cycle, Krebs;

Allowable Qualifiers: drug effects; genetics; immunology; physiology; radiation effects;

Tree Number: G02.111.087.165; G02.149.115.165; G03.495.335.342; G03.495.553.170;

Online Note: use CITRIC ACID CYCLE to search KREBS CYCLE 1966-84

History Note: 85; was KREBS CYCLE 1963-84