Clinical Trials as Topic - Statistics & numerical data
Research News and Information

Saturday, November 21, 2009

The present efficacy of multiple sclerosis therapeutics: Is the new 66% just the old 33%?

20 Sep 2009 A challenge for the clinician treating patients with multiple sclerosis (MS) is to determine the most effective treatment while weighing the benefits and risks. Results of the phase 2 and phase 3 studies on natalizumab were received with great ... Read more...

Meta-analytic interval estimation for standardized and unstandardized mean differences.

30 Aug 2009 The fixed-effects (FE) meta-analytic confidence intervals for unstandardized and standardized mean differences are based on an unrealistic assumption of effect-size homogeneity and perform poorly when this assumption is violated. The random-effects ... Read more...

A review of dissociative disorders treatment studies.

30 Aug 2009 This review examines empirical reports of treatment for Dissociative Disorders (DD), including 16 DD treatment outcome studies and 4 case studies that used standardized measures. Collectively, these reports suggest that treatment for DD is ... Read more...

Latest indexed articles for 'Clinical Trials as Topic - Statistics & numerical data'

These are the very latest articles for this heading:

• Dropouts and missing data in psychiatric clinical trials. 30 Oct 2009
• The present efficacy of multiple sclerosis therapeutics: Is the new 66% just the old 33%? 20 Sep 2009
• Pitfalls in meta-analysis of observational studies: lessons from a systematic review of the risks of stenting for intracranial atherosclerosis. 8 Sep 2009
• Analysis of SPARCL trial data for reduction of future stroke risk in older stroke patients with recent stroke or TIA. 6 Sep 2009
• Meta-analytic interval estimation for standardized and unstandardized mean differences. 30 Aug 2009
• Bringing arts-based therapies in from the scientific cold. 30 Aug 2009
• Assessment: botulinum neurotoxin for the treatment of spasticity (an evidence-based review). 30 Aug 2009
• A change is in the wind as 'adaptive' clinical trials catch on. 30 Aug 2009
• A review of dissociative disorders treatment studies. 30 Aug 2009
• A hundred (and one) graphs tell only part of the story. 30 Aug 2009
• Thrombolysis in stroke: still not ready for community hospital use by emergency physicians. 30 Aug 2009
• Testing new ideas: is a picture worth a thousand words? 30 Aug 2009
• The effect of the European Clinical Trials Directive on published drug research in anaesthesia. 30 Aug 2009
• A behavioral Bayes method to determine the sample size of a clinical trial considering efficacy and safety. 13 Aug 2009
• Varying cluster sizes in trials with clusters in one treatment arm: sample size adjustments when testing treatment effects with linear mixed models. 13 Aug 2009
• Disagreements in meta-analyses using outcomes measured on continuous or rating scales: observer agreement study. 11 Aug 2009
• From trial and error to trial simulation. Part 2: an appraisal of current beliefs in the design and analysis of clinical trials for antidepressant drugs. 10 Aug 2009
• Same, better, or worse? Neurocognitive effects of radiotherapy for low-grade gliomas remain unknown. 5 Aug 2009
• From trial and error to trial simulation. Part 1: the importance of model-based drug development for antidepressant drugs. 3 Aug 2009
• Use of statins and incidence of dementia and cognitive impairment without dementia in a cohort study. 2 Aug 2009

See a longer list of these articles.

Technical information about 'Clinical Trials as Topic'

Definition: Pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.

Descriptor UI: D002986

Alternative terms: Clinical Trials as Topic; Clinical Trial as Topic;

Related Mesh Headings: Meta-Analysis as Topic; Drug Approval; Clinical Trials Data Monitoring Committees; Therapies, Investigational;

Allowable Qualifiers: adverse effects; classification; economics; history; instrumentation; methods; mortality; nursing; psychology; standards; trends; utilization; veterinary; statistics & numerical data; contraindications; ethics; legislation & jurisprudence;

Tree Number: E05.318.760.535; E05.337.250; N05.715.360.775.235; N06.850.520.450.535;

History Note: 2008(1965)

Technical Notes: for general design, methodology, economics, etc. of clinical trials; a different heading CLINICAL TRIAL is used for reports of a specific clinical trial