Clonidine - Adverse effects
Research News and Information

Saturday, November 21, 2009

A phase II clinical trial to assess the safety of clonidine in acute organophosphorus pesticide poisoning.

18 Aug 2009 BACKGROUND: An estimated 2-3 million people are acutely poisoned by organophosphorus pesticides each year, mostly in the developing world. There is a pressing need for new affordable antidotes and clonidine has been shown to be effective in animal ... Read more...

Clonidine as an adjuvant to local anesthetics for peripheral nerve and plexus blocks: a meta-analysis of randomized trials.

30 Jul 2009 The effect of adding clonidine to local anesthetics for nerve or plexus blocks remains unclear. The authors searched for randomized placebo-controlled trials testing the impact of adding clonidine to local anesthetics for peripheral single-injection ... Read more...

[Severe differed respiratory depression after intrathecal administration of morphine and clonidine on a 70-year-old patient]

5 Jul 2009 We report a case of severe and differed respiratory depression to a 70-year-old patient after spinal anaesthesia for prostatic adenomectomy. Ten milligram of bupivacaine, 30 microg of clonidine and 100 microg of morphine has been administrated ... Read more...

Latest indexed articles for 'Clonidine - Adverse effects'

These are the very latest articles for this heading:

• A phase II clinical trial to assess the safety of clonidine in acute organophosphorus pesticide poisoning. 18 Aug 2009
• Clonidine as an adjuvant to local anesthetics for peripheral nerve and plexus blocks: a meta-analysis of randomized trials. 30 Jul 2009
• [Severe differed respiratory depression after intrathecal administration of morphine and clonidine on a 70-year-old patient] 5 Jul 2009
• [Efficacy of clonidine transdermal patch for treatment of Tourette's syndrome in children] 29 Jun 2009
• Addition of clonidine or dexmedetomidine to bupivacaine prolongs caudal analgesia in children. 16 Jun 2009
• Case report: postoperative analgesia and preserved motor function with clonidine and buprenorphine via a sciatic perineural catheter. 4 Jun 2009
• Exposure to topical apraclonidine in children with glaucoma. 30 May 2009
• Cephalad migration of intrathecal clonidine in an infant undergoing bilateral herniorrhaphy. 26 May 2009
• Electrocardiographic effects of lofexidine and methadone coadministration: secondary findings from a safety study. 29 Apr 2009
• Unilateral spinal anaesthesia for outpatient surgery: a comparison between hyperbaric bupivacaine and bupivacaine-clonidine combination. 12 Apr 2009
• Amlodipine-induced myoclonus. 30 Mar 2009
• Interaction between clonidine and escitalopram. 30 Mar 2009
• The analgesic effect of epidural clonidine after spinal surgery: a randomized placebo-controlled trial. 30 Jan 2009
• Is norepinephrine an etiological factor in some types of cancer? 13 Jan 2009
• Be vigilant, always! 30 Dec 2008
• Be vigilant during use of intrathecal clonidine in former preterm infants. 30 Dec 2008
• Alpha 2A-adrenergic receptor signaling underlies synergistic enhancement of ethanol-induced behavioral impairment by clonidine. 11 Dec 2008
• Relative bioavailability of tizanidine hydrochloride capsule formulation compared with capsule contents administered in applesauce: a single-dose, open-label, randomized, two-way, crossover study in fasted healthy adult subjects. 29 Nov 2008
• [Peridural application of ropivacaine and clonidine for pain therapy after prostatectomy] 29 Nov 2008
• Insomnia, night terror, and depression related to clonidine in attention-deficit/hyperactivity disorder. 29 Nov 2008

See a longer list of these articles.

Technical information about 'Clonidine'

Definition: An alpha-2 adrenergic agonist that crosses the blood-brain barrier. Clonidine acts centrally by reducing sympathetic tone, resulting in a fall in diastolic and systolic blood pressure and a reduction in heart rate. It also acts peripherally, and this peripheral activity may be responsible for the transient increase in blood pressure seen during rapid intravenous administration. (From Martindale, the Extra Pharmacopoeia, 30th ed, p350)

Chemical name: 1H-Imidazol-2-amine, N-(2,6-dichlorophenyl)-4,5-dihydro-

Registry Number: 4205-90-7

Descriptor UI: D003000

Alternative terms: Clonidine; Klofenil; Clofenil; M-5041T; M 5041T; M5041T; ST-155; ST 155; ST155; Clonidine Monohydrobromide; Monohydrobromide, Clonidine; Clonidine Monohydrochloride; Monohydrochloride, Clonidine; Dixarit; Clonidine Hydrochloride; Hydrochloride, Clonidine; Hemiton; Isoglaucon; Catapres; Catapresan; Catapressan; Chlophazolin; Clonidine Dihydrochloride; Dihydrochloride, Clonidine; Klofelin; Clopheline; Clofelin; Gemiton;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: Adrenergic alpha-Agonists; Analgesics; Antihypertensive Agents; Sympatholytics;

Tree Number: D03.383.129.308.436.500;

History Note: 73(72)