Clonidine - Therapeutic use
Research News and Information

Sunday, November 22, 2009

Alpha2-receptor agonists for treatment and prevention of iatrogenic opioid abstinence syndrome in critically ill patients.

16 Aug 2009 OBJECTIVE: To review the literature regarding the use of alpha(2)-agonists in the treatment and prevention of iatrogenic opioid abstinence syndrome (IOAS) in critically ill patients. DATA SOURCES: Primary literature was identified through a search ... Read more...

Clonidine in perioperative medicine and intensive care unit: more than an anti-hypertensive drug.

30 Jul 2009 Clonidine is classified as an imidazoline and it is the prototypical alpha-2 receptor agonists. It has been used for several years to treat hypertension. It has also been used, "off label", for a variety of purposes, including opioid and anesthetic ... Read more...

Buprenorphine for the management of opioid withdrawal.

6 Jul 2009 BACKGROUND: Managed withdrawal is a necessary step prior to drug-free treatment or as the end point of substitution treatment. OBJECTIVES: To assess the effectiveness of interventions involving the use of buprenorphine to manage opioid withdrawal, ... Read more...

Latest indexed articles for 'Clonidine - Therapeutic use'

These are the very latest articles for this heading:

• The possible mechanism of clonidine to suppress fentanyl-induced coughing. 29 Sep 2009
• Alpha2-receptor agonists for treatment and prevention of iatrogenic opioid abstinence syndrome in critically ill patients. 16 Aug 2009
• Clonidine in perioperative medicine and intensive care unit: more than an anti-hypertensive drug. 30 Jul 2009
• Buprenorphine for the management of opioid withdrawal. 6 Jul 2009
• [Severe differed respiratory depression after intrathecal administration of morphine and clonidine on a 70-year-old patient] 5 Jul 2009
• [Efficacy of intraoperative methadone and clonidine in pain control in the immediate postoperative period after the use of remifentanil] 29 Jun 2009
• Use of clonidine in the prevention and management of neonatal abstinence syndrome. 29 Jun 2009
• Pharmacological analysis of alpha(2)-adrenoceptor subtypes mediating analgesic, anti-inflammatory and gastroprotective actions. 11 Jun 2009
• Case report: postoperative analgesia and preserved motor function with clonidine and buprenorphine via a sciatic perineural catheter. 4 Jun 2009
• [Spinal granuloma in a patient receiving a spinal infusion of morphine and clonidine] 30 May 2009
• Preoperative clonidine or levobupivacaine--effect on systemic inflammatory stress response. 30 May 2009
• Double-blind, crossover study of clonidine and levetiracetam in Tourette syndrome. 30 May 2009
• The efficacy of intrathecal morphine with or without clonidine for postoperative analgesia after radical prostatectomy. 30 May 2009
• Intrathecal administration of clonidine attenuates spinal neuroimmune activation in a rat model of neuropathic pain with existing hyperalgesia. May 2009
• Clonidine as an adjunct therapy to opioids for neonatal abstinence syndrome: a randomized, controlled trial. 25 Apr 2009
• Detoxification treatments for opiate dependent adolescents. 13 Apr 2009
• Clonidine improves hyperarousal in borderline personality disorder with or without comorbid posttraumatic stress disorder: a randomized, double-blind, placebo-controlled trial. 30 Mar 2009
• Alpha2-adrenergic agonists and their role in the prevention of perioperative adverse cardiac events. 30 Mar 2009
• Botulinum toxin should be first-line treatment for poststroke spasticity. 30 Mar 2009
• Intensity of opiate withdrawal in relation to the 825C>T polymorphism of the G-protein beta 3 subunit gene. 17 Mar 2009

See a longer list of these articles.

Technical information about 'Clonidine'

Definition: An alpha-2 adrenergic agonist that crosses the blood-brain barrier. Clonidine acts centrally by reducing sympathetic tone, resulting in a fall in diastolic and systolic blood pressure and a reduction in heart rate. It also acts peripherally, and this peripheral activity may be responsible for the transient increase in blood pressure seen during rapid intravenous administration. (From Martindale, the Extra Pharmacopoeia, 30th ed, p350)

Chemical name: 1H-Imidazol-2-amine, N-(2,6-dichlorophenyl)-4,5-dihydro-

Registry Number: 4205-90-7

Descriptor UI: D003000

Alternative terms: Clonidine; Klofenil; Clofenil; M-5041T; M 5041T; M5041T; ST-155; ST 155; ST155; Clonidine Monohydrobromide; Monohydrobromide, Clonidine; Clonidine Monohydrochloride; Monohydrochloride, Clonidine; Dixarit; Clonidine Hydrochloride; Hydrochloride, Clonidine; Hemiton; Isoglaucon; Catapres; Catapresan; Catapressan; Chlophazolin; Clonidine Dihydrochloride; Dihydrochloride, Clonidine; Klofelin; Clopheline; Clofelin; Gemiton;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: Adrenergic alpha-Agonists; Analgesics; Antihypertensive Agents; Sympatholytics;

Tree Number: D03.383.129.308.436.500;

History Note: 73(72)