Clonidine
Research News and Information

Saturday, November 21, 2009

Perineural dexmedetomidine added to ropivacaine causes a dose-dependent increase in the duration of thermal antinociception in sciatic nerve block in rat.

30 Oct 2009 BACKGROUND: The current study was designed to test the hypothesis that dexmedetomidine added to ropivacaine would increase the duration of antinociception to a thermal stimulus in a dose-dependent fashion in a rat model of sciatic nerve blockade. ... Read more...

Protein kinase C mediates the synergistic interaction between agonists acting at alpha2-adrenergic and delta-opioid receptors in spinal cord.

19 Oct 2009 Coactivation of spinal alpha(2)-adrenergic receptors (ARs) and opioid receptors produces antinociceptive synergy. Antinociceptive synergy between intrathecally administered alpha(2)AR and opioid agonists is well documented, but the mechanism ... Read more...

Toxicity from a clonidine suspension.

30 Aug 2009 BACKGROUND: Clonidine is frequently prescribed to children. Clonidine overdose in children has resulted in major clinical effects and deaths. CASE REPORT: A 3.5-year-old male with a history of a seizure disorder and night terrors presented following ... Read more...

Latest indexed articles for 'Clonidine'

These are the very latest articles for this heading:

• Perineural dexmedetomidine added to ropivacaine causes a dose-dependent increase in the duration of thermal antinociception in sciatic nerve block in rat. 30 Oct 2009
• Protein kinase C mediates the synergistic interaction between agonists acting at alpha2-adrenergic and delta-opioid receptors in spinal cord. 19 Oct 2009
• The possible mechanism of clonidine to suppress fentanyl-induced coughing. 29 Sep 2009
• Re: Addition of clonidine or dexmedetomidine to bupivacaine prolongs caudal analgesia in children. 29 Sep 2009
• Toxicity from a clonidine suspension. 30 Aug 2009
• An Osteoblast-dependent mechanism contributes to the leptin regulation of insulin secretion. 30 Aug 2009
• Current pharmacologic testing for Horner syndrome. 30 Aug 2009
• A phase II clinical trial to assess the safety of clonidine in acute organophosphorus pesticide poisoning. 18 Aug 2009
• Noradrenergic modulation of neuronal responses to glutamate in the vestibular complex. 18 Aug 2009
• Alpha2-receptor agonists for treatment and prevention of iatrogenic opioid abstinence syndrome in critically ill patients. 16 Aug 2009
• Clonidine in perioperative medicine and intensive care unit: more than an anti-hypertensive drug. 30 Jul 2009
• New drugs for epidural analgesia. 30 Jul 2009
• CFTR Cl- channel functional regulation by phosphorylation of focal adhesion kinase at tyrosine 407 in osmosensitive ion transporting mitochondria rich cells of euryhaline killifish. 30 Jul 2009
• Examination of reinforcement magnitude on the pharmacological disruption of fixed-ratio performance. 30 Jul 2009
• Possible effect of systemic sympathicolytic drugs on apraclonidine test. 30 Jul 2009
• Clonidine as an adjuvant to local anesthetics for peripheral nerve and plexus blocks: a meta-analysis of randomized trials. 30 Jul 2009
• The antinociceptive effects of intravenous dexmedetomidine in colorectal distension-induced visceral pain in rats: the role of opioid receptors. 30 Jul 2009
• Buprenorphine for the management of opioid withdrawal. 6 Jul 2009
• [Severe differed respiratory depression after intrathecal administration of morphine and clonidine on a 70-year-old patient] 5 Jul 2009
• [Efficacy of intraoperative methadone and clonidine in pain control in the immediate postoperative period after the use of remifentanil] 29 Jun 2009

See a longer list of these articles.

Technical information about 'Clonidine'

Definition: An alpha-2 adrenergic agonist that crosses the blood-brain barrier. Clonidine acts centrally by reducing sympathetic tone, resulting in a fall in diastolic and systolic blood pressure and a reduction in heart rate. It also acts peripherally, and this peripheral activity may be responsible for the transient increase in blood pressure seen during rapid intravenous administration. (From Martindale, the Extra Pharmacopoeia, 30th ed, p350)

Chemical name: 1H-Imidazol-2-amine, N-(2,6-dichlorophenyl)-4,5-dihydro-

Registry Number: 4205-90-7

Descriptor UI: D003000

Alternative terms: Clonidine; Klofenil; Clofenil; M-5041T; M 5041T; M5041T; ST-155; ST 155; ST155; Clonidine Monohydrobromide; Monohydrobromide, Clonidine; Clonidine Monohydrochloride; Monohydrochloride, Clonidine; Dixarit; Clonidine Hydrochloride; Hydrochloride, Clonidine; Hemiton; Isoglaucon; Catapres; Catapresan; Catapressan; Chlophazolin; Clonidine Dihydrochloride; Dihydrochloride, Clonidine; Klofelin; Clopheline; Clofelin; Gemiton;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: Adrenergic alpha-Agonists; Analgesics; Antihypertensive Agents; Sympatholytics;

Tree Number: D03.383.129.308.436.500;

History Note: 73(72)