Coagulants
Research News and Information

Sunday, November 22, 2009

The use of recombinant activated factor VIIa in coagulopathic traumatic brain injuries requiring emergent craniotomy: is it beneficial?

29 Sep 2009 OBJECT: The role of recombinant activated factor VII (rFVIIa) in traumatic brain injury (TBI) has not been well established. This study evaluates the outcomes of using rFVIIa as first-line therapy in patients with a severe TBI requiring emergent ... Read more...

Dyspnoea in a young woman with active systemic lupus erythematosus.

30 Jul 2009 Diffuse alveolar haemorrhage (DAH) is a rare but life-threatening complication of systemic lupus erythematosus (SLE). We present the case of a 24-year-old Cambodian woman with SLE followed in the Brigham and Women's Hospital Lupus Center in Boston, ... Read more...

Pharmacokinetics and dose requirements of factor VIII over the age range 3-74 years: a population analysis based on 50 patients with long-term prophylactic treatment for haemophilia A.

24 Jun 2009 PURPOSE: The three aims of this investigation were (1) to develop a population pharmacokinetic (PK) model for factor VIII (FVIII) in haemophilia A patients, with estimates of inter-occasion and inter-individual variance, (2) to investigate whether ... Read more...

Latest indexed articles for 'Coagulants'

These are the very latest articles for this heading:

• The use of recombinant activated factor VIIa in coagulopathic traumatic brain injuries requiring emergent craniotomy: is it beneficial? 29 Sep 2009
• Traumatic haemorrhage: a role for recombinant factor VIIa? 29 Sep 2009
• The "off-label" role of recombinant factor VIIa in surgery: is the problem deficient evidence or defective concept? 17 Sep 2009
• Prothrombin complex concentrate and fatal thrombosis: poor evidence to implicate a relatively safe drug. 30 Aug 2009
• Successful treatment of intractable hemorrhage with recombinant factor VIIa during cranial vault reconstruction in an infant. 30 Jul 2009
• Dyspnoea in a young woman with active systemic lupus erythematosus. 30 Jul 2009
• Pharmacokinetics and dose requirements of factor VIII over the age range 3-74 years: a population analysis based on 50 patients with long-term prophylactic treatment for haemophilia A. 24 Jun 2009
• Hemostatic and hemorrhagic problems in neurosurgical patients. 24 Jun 2009
• Elevated procoagulant microparticles expressing endothelial and platelet markers in essential thrombocythemia. 6 Jun 2009
• Inactivation of plasminogen activator inhibitor type 1 by activated factor XII plays a role in the enhancement of fibrinolysis by contact factors in-vitro. Jun 2009
• Successful treatment with rituximab in an elderly patient with acquired factor VIII inhibitor. 30 May 2009
• The frequency of bleeding complications after invasive dental treatment in patients receiving single and dual antiplatelet therapy. 30 May 2009
• rFV11a and paediatric open-heart surgery: thrombosis in the cardiopulmonary bypass circuit in spite of adequate markers of anticoagulation. 30 May 2009
• Severely diminished response to vitamin K-treatment for self-inflicted warfarin intoxication in a patient genotyped as CYP2C9*3*3. 28 May 2009
• A new inorganic-organic composite coagulant, consisting of polyferric sulphate (PFS) and polyacrylamide (PAA). 18 May 2009
• In vitro anticoagulation monitoring of low-molecular-weight heparin. 18 May 2009
• Long-term results of central venous access devices in children with haemophilia. 18 May 2009
• Bleeding management with fibrinogen concentrate targeting a high-normal plasma fibrinogen level: a pilot study. 30 Apr 2009
• Quantifying the source of infection for HIV-infected hemophiliacs in the U.K. from 1979 to 1984. 29 Apr 2009
• Spinal epidural hematoma in hemophilic children: controversies in management. 8 Apr 2009

See a longer list of these articles.

Technical information about 'Coagulants'

Definition: Exogenous substances used to promote blood coagulation. The endogenous BLOOD COAGULATION FACTORS are considered to be coagulants only when administered as drugs.

Registry Number: 0

Descriptor UI: D003029

Alternative terms: Coagulants;

Related Mesh Headings: Blood Coagulation Factors; Thrombin;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Tree Number: D27.505.954.502.270;

Online Note: search HEMOSTATICS 1966-74

History Note: 75; was see under HEMOSTATICS 1963-74

Technical Notes: consider also BLOOD COAGULATION /drug eff