Cobalt - Pharmacology
Research News and Information

Sunday, November 22, 2009

Characterization and structure of the manganese-responsive transcriptional regulator ScaR.

Nov 2009 The streptococcal coaggregation regulator (ScaR) of Streptococcus gordonii is a manganese-dependent transcriptional regulator. When intracellular manganese concentrations become elevated, ScaR represses transcription of the scaCBA operon, which ... Read more...

Opposite role of infralimbic and prelimbic cortex in the tachycardiac response evoked by acute restraint stress in rats.

13 Aug 2009 The ventral medial prefrontal cortex (vMPFC) comprises the prelimbic cortex (PL) and the infralimbic cortex (IL). Conflicting results have been reported from studies aiming to investigate the role played by the vMPFC in behavioral and autonomic ... Read more...

Heme oxygenase-1 induction modulates hypoxic pulmonary vasoconstriction through upregulation of ecSOD.

5 Aug 2009 Endothelium-denuded bovine pulmonary arteries (BPA) contract to hypoxia through a mechanism potentially involving removing a superoxide-derived hydrogen peroxide-mediated relaxation. BPA organ cultured for 24 h with 0.1 mM cobalt chloride (CoCl(2)) ... Read more...

Latest indexed articles for 'Cobalt - Pharmacology'

These are the very latest articles for this heading:

• Characterization and structure of the manganese-responsive transcriptional regulator ScaR. Nov 2009
• Opposite role of infralimbic and prelimbic cortex in the tachycardiac response evoked by acute restraint stress in rats. 13 Aug 2009
• Heme oxygenase-1 induction modulates hypoxic pulmonary vasoconstriction through upregulation of ecSOD. 5 Aug 2009
• T-type calcium channels are regulated by hypoxia/reoxygenation in ventricular myocytes. 5 Aug 2009
• Targeted inhibition of Snail family zinc finger transcription factors by oligonucleotide-Co(III) Schiff base conjugate. Aug 2009
• Downregulation of gap junction expression and function by endoplasmic reticulum stress. 30 Jul 2009
• Cobalt chloride-induced hypoxia modulates the invasive potential and matrix metalloproteinases of primary and metastatic breast cancer cells. 30 Jul 2009
• MrdH, a novel metal resistance determinant of Pseudomonas putida KT2440, is flanked by metal-inducible mobile genetic elements. 29 Jul 2009
• Dioxin receptor deficiency impairs angiogenesis by a mechanism involving VEGF-A depletion in the endothelium and transforming growth factor-beta overexpression in the stroma. 16 Jul 2009
• Dicamba monooxygenase: structural insights into a dynamic Rieske oxygenase that catalyzes an exocyclic monooxygenation. 13 Jul 2009
• Molecular mechanisms of HIF-1alpha modulation induced by oxygen tension and BMP2 in glioblastoma derived cells. 7 Jul 2009
• Isolation of cobalt hyper-resistant mutants of Saccharomyces cerevisiae by in vivo evolutionary engineering approach. Jul 2009
• In vitro effects of hypoxia-inducible factor 1alpha on the biological characteristics of the SiHa uterine cervix cancer cell line. 29 Jun 2009
• Soluble and particulate Co-Cr-Mo alloy implant metals activate the inflammasome danger signaling pathway in human macrophages: a novel mechanism for implant debris reactivity. 29 Jun 2009
• Interaction of drug based binuclear mixed-ligand complexes with DNA. 15 Jun 2009
• Real-time nanomechanical and topographical mapping on live bacterial cells-Brevibacterium casei under stress due to their exposure to Co2+ ions during microbial synthesis of Co3O4 nanoparticles. 2 Jun 2009
• CoCl(2) induces apoptosis via the 18 kDa translocator protein in U118MG human glioblastoma cells. 31 May 2009
• Heterochromatinization as a potential mechanism of nickel-induced carcinogenesis. 31 May 2009
• Adenine nucleotide translocase-1 induces cardiomyocyte death through upregulation of the pro-apoptotic protein Bax. 30 May 2009
• Molecular characterization of a new acetyl xylan esterase (AXEII) from edible straw mushroom Volvariella volvacea with both de-O-acetylation and de-N-acetylation activity. 30 May 2009

See a longer list of these articles.

Technical information about 'Cobalt'

Definition: A trace element that is a component of vitamin B12. It has the atomic symbol Co, atomic number 27, and atomic weight 58.93. It is used in nuclear weapons, alloys, and pigments. Deficiency in animals leads to anemia; its excess in humans can lead to erythrocytosis.

Chemical name: Cobalt

Registry Number: 7440-48-4

Descriptor UI: D003035

Alternative terms: Cobalt;

Related Mesh Headings: Cobalt Isotopes; Cobalt Radioisotopes;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; classification; deficiency; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: Trace Elements;

Tree Number: D01.268.556.185; D01.268.956.155; D01.552.544.185;

Technical Notes: Co-59