Cocaine - Administration & dosage
Research News and Information

Saturday, November 21, 2009

Diffusion tensor imaging in cocaine dependence: regional effects of cocaine on corpus callosum and effect of cocaine administration route.

29 Sep 2009 Recent studies demonstrated that diffusion tensor imaging (DTI) can provide information regarding white matter integrity of the corpus callosum (CC). In this study, DTI parameters were compared between cocaine dependent subjects (CDs) and non-drug ... Read more...

Regulation of dynamin 2 and G protein-coupled receptor kinase 2 in rat nucleus accumbens during acute and repeated cocaine administration.

29 Sep 2009 Exposure to cocaine causes many neuroadaptations including alterations in several neurotransmitter receptors and transporters. This study investigated potential mechanisms of cocaine-induced receptor and transporter regulation by measuring levels of ... Read more...

c-Fos expression associated with reinstatement of cocaine-seeking behavior by response-contingent conditioned cues.

29 Sep 2009 The capability of cocaine cues to generate craving in cocaine-dependent humans, even after extended abstinence, is modeled in rats using cue reinstatement of extinguished cocaine-seeking behavior. We investigated neural activity associated with ... Read more...

Latest indexed articles for 'Cocaine - Administration & dosage'

These are the very latest articles for this heading:

• Diffusion tensor imaging in cocaine dependence: regional effects of cocaine on corpus callosum and effect of cocaine administration route. 29 Sep 2009
• Regulation of dynamin 2 and G protein-coupled receptor kinase 2 in rat nucleus accumbens during acute and repeated cocaine administration. 29 Sep 2009
• c-Fos expression associated with reinstatement of cocaine-seeking behavior by response-contingent conditioned cues. 29 Sep 2009
• Neural encoding of cocaine-seeking behavior is coincident with phasic dopamine release in the accumbens core and shell. 2 Sep 2009
• Basolateral amygdala involvement in memory reconsolidation processes that facilitate drug context-induced cocaine seeking. 25 Aug 2009
• Dorsal hippocampal regulation of memory reconsolidation processes that facilitate drug context-induced cocaine-seeking behavior in rats. 25 Aug 2009
• Attenuated behavioural responses to acute and chronic cocaine in GASP-1-deficient mice. 25 Aug 2009
• Yoked delivery of cocaine is aversive and protects against the motivation for drug in rats. 30 Jul 2009
• Environmental and pharmacological factors in the development of noncontingent tolerance to cocaine in pigeons. 30 Jul 2009
• Repeated dosing with oral cocaine in humans: assessment of direct effects, withdrawal, and pharmacokinetics. 30 Jul 2009
• A phase 1 trial of pharmacologic interactions between transdermal selegiline and a 4-hour cocaine infusion. 30 Jul 2009
• Acquisition of and withdrawal from cocaine self-administration regulates 5-HT mRNA expression in rat striatum. 28 Jul 2009
• Upregulation of GLT1 attenuates cue-induced reinstatement of cocaine-seeking behavior in rats. 20 Jul 2009
• Lack of cocaine self-administration in mice expressing a cocaine-insensitive dopamine transporter. 12 Jul 2009
• Effects of environmental enrichment on sensitivity to cocaine in female rats: importance of control rates of behavior. 29 Jun 2009
• Behavioral momentum of cocaine self-administration: effects of frequency of reinforcement on resistance to extinction. 29 Jun 2009
• Extended daily access to cocaine results in distinct alterations in Homer 1b/c and NMDA receptor subunit expression within the medial prefrontal cortex. 29 Jun 2009
• Khantzian's 'self-medication hypothesis' of drug addiction and films by Martin Scorsese. 30 May 2009
• Prolonged withdrawal from repeated noncontingent cocaine exposure increases NMDA receptor expression and ERK activity in the nucleus accumbens. 25 May 2009
• Chronic cocaine enhances corticotropin-releasing factor-dependent potentiation of excitatory transmission in ventral tegmental area dopamine neurons. 18 May 2009

See a longer list of these articles.

Technical information about 'Cocaine'

Definition: An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse. Cocaine, like amphetamines, acts by multiple mechanisms on brain catecholaminergic neurons; the mechanism of its reinforcing effects is thought to involve inhibition of dopamine uptake.

Chemical name: 8-Azabicyclo(3.2.1)octane-2-carboxylic acid, 3-(benzoyloxy)-8-methyl-, methyl ester, (1R-(exo,exo))-

Registry Number: 50-36-2

Descriptor UI: D003042

Alternative terms: Cocaine; Cocaine Hydrochloride; Hydrochloride, Cocaine; Cocaine HCl; HCl, Cocaine;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: Vasoconstrictor Agents; Dopamine Uptake Inhibitors; Anesthetics, Local;

Tree Number: D02.145.074.722.388; D03.132.889.354; D03.605.869.388; D04.075.080.875.099.722.388;

Online Note: use COCAINE/analogs & derivatives to search COCAINE DERIVATIVES 1975-77; use TROPANES 1969-74

History Note: COCAINE DERIVATIVES was see under COCAINE 1975-77; was see under TROPANES 1969-74

Technical Notes: cocaine derivatives = COCAINE /analogs;CRACK COCAINE is available; cocaine addiction = COCAINE-RELATED DISORDERS