Cocaine - Pharmacokinetics
Research News and Information

Sunday, November 22, 2009

Repeated dosing with oral cocaine in humans: assessment of direct effects, withdrawal, and pharmacokinetics.

30 Jul 2009 Cocaine withdrawal symptoms are thought to play a role in relapse; studies characterizing the symptomatology have yielded mixed findings. This study sought to examine the pharmacodynamic/pharmacokinetic profile of repeated high dose exposure to oral ... Read more...

A phase 1 trial of pharmacologic interactions between transdermal selegiline and a 4-hour cocaine infusion.

30 Jul 2009 BACKGROUND: The selective MAO-B inhibitor selegiline has been evaluated in clinical trials as a potential medication for the treatment of cocaine dependence. This study evaluated the safety of and pharmacologic interactions between 7 days of ... Read more...

Extra-medical stimulant dependence among recent initiates.

7 Jun 2009 New estimates for the risk of becoming stimulant dependent within 24 months after first extra-medical (EM) use of a stimulant drug compound are presented, with a focus on subgroup variations in this risk (e.g., alcohol dependence, male-female ... Read more...

Latest indexed articles for 'Cocaine - Pharmacokinetics'

These are the very latest articles for this heading:

• Repeated dosing with oral cocaine in humans: assessment of direct effects, withdrawal, and pharmacokinetics. 30 Jul 2009
• A phase 1 trial of pharmacologic interactions between transdermal selegiline and a 4-hour cocaine infusion. 30 Jul 2009
• Extra-medical stimulant dependence among recent initiates. 7 Jun 2009
• Pharmacokinetics of disappearance of cocaine from hair after discontinuation of drug use. 28 May 2009
• Striatal dopamine responses to intranasal cocaine self-administration in humans. 25 Feb 2009
• Diffusion tensor imaging of cocaine-treated rodents. 10 Feb 2009
• Cocaine: history, social implications, and toxicity: a review. 30 Jan 2009
• The effect of a chimeric human/murine anti-cocaine monoclonal antibody on cocaine self-administration in rats. 14 Dec 2008
• Effects of the H3 receptor inverse agonist thioperamide on cocaine-induced locomotion in mice: role of the histaminergic system and potential pharmacokinetic interactions. 7 Oct 2008
• Selective hyposmia in Parkinson disease: association with hippocampal dopamine activity. 28 Sep 2008
• Opioid and cocaine combined effect on cocaine-induced changes in HPA and HPG axes hormones in men. 16 Sep 2008
• Evaluation of a pharmacokinetic hypothesis for reduced locomotor stimulation from methamphetamine and cocaine in adolescent versus adult male C57BL/6J mice. 15 Sep 2008
• Fast uptake and long-lasting binding of methamphetamine in the human brain: comparison with cocaine. 20 Jul 2008
• The binding sites for cocaine and dopamine in the dopamine transporter overlap. 20 Jun 2008
• Modafinil: a useful medication for cocaine addiction? Review of the evidence from neuropharmacological, experimental and clinical studies. 30 May 2008
• Gamma-hydroxybutyric acid (GHB) measurement by GC-MS in blood, urine and gastric contents, following an acute intoxication in Belgium. 29 Apr 2008
• Failure of amoxicillin to produce false-positive urine screens for cocaine metabolite. 29 Apr 2008
• Neurokinin B/NK3 receptors exert feedback inhibition on L-DOPA actions in the 6-OHDA lesion rat model of Parkinson's disease. 16 Mar 2008
• Loss of thalamic serotonin transporters in early drug-naïve Parkinson's disease patients is associated with tremor: an [(123)I]beta-CIT SPECT study. 10 Mar 2008
• Ex vivo evaluation of N-(3-[18F]fluoropropyl)-2 beta-carbomethoxy-3 beta-(4-fluorophenyl)nortropane in rats. 30 Jan 2008

See a longer list of these articles.

Technical information about 'Cocaine'

Definition: An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse. Cocaine, like amphetamines, acts by multiple mechanisms on brain catecholaminergic neurons; the mechanism of its reinforcing effects is thought to involve inhibition of dopamine uptake.

Chemical name: 8-Azabicyclo(3.2.1)octane-2-carboxylic acid, 3-(benzoyloxy)-8-methyl-, methyl ester, (1R-(exo,exo))-

Registry Number: 50-36-2

Descriptor UI: D003042

Alternative terms: Cocaine; Cocaine Hydrochloride; Hydrochloride, Cocaine; Cocaine HCl; HCl, Cocaine;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: Vasoconstrictor Agents; Dopamine Uptake Inhibitors; Anesthetics, Local;

Tree Number: D02.145.074.722.388; D03.132.889.354; D03.605.869.388; D04.075.080.875.099.722.388;

Online Note: use COCAINE/analogs & derivatives to search COCAINE DERIVATIVES 1975-77; use TROPANES 1969-74

History Note: COCAINE DERIVATIVES was see under COCAINE 1975-77; was see under TROPANES 1969-74

Technical Notes: cocaine derivatives = COCAINE /analogs;CRACK COCAINE is available; cocaine addiction = COCAINE-RELATED DISORDERS