Cocaine - Pharmacology
Research News and Information

Saturday, November 21, 2009

A neurocomputational model for cocaine addiction.

29 Sep 2009 Based on the dopamine hypotheses of cocaine addiction and the assumption of decrement of brain reward system sensitivity after long-term drug exposure, we propose a computational model for cocaine addiction. Utilizing average reward temporal ... Read more...

c-Fos expression associated with reinstatement of cocaine-seeking behavior by response-contingent conditioned cues.

29 Sep 2009 The capability of cocaine cues to generate craving in cocaine-dependent humans, even after extended abstinence, is modeled in rats using cue reinstatement of extinguished cocaine-seeking behavior. We investigated neural activity associated with ... Read more...

Similar neurons, opposite adaptations: psychostimulant experience differentially alters firing properties in accumbens core versus shell.

28 Sep 2009 The principal components of neuronal excitability include synaptic and intrinsic membrane parameters. While recent studies indicate that cocaine exposure can induce widespread changes in synaptic function in the neural circuits for reward, intrinsic ... Read more...

Latest indexed articles for 'Cocaine - Pharmacology'

These are the very latest articles for this heading:

• A neurocomputational model for cocaine addiction. 29 Sep 2009
• c-Fos expression associated with reinstatement of cocaine-seeking behavior by response-contingent conditioned cues. 29 Sep 2009
• Similar neurons, opposite adaptations: psychostimulant experience differentially alters firing properties in accumbens core versus shell. 28 Sep 2009
• [Neuroenhancement: doping for the brain] 27 Sep 2009
• Orbitofrontal and anterior cingulate cortex neurons selectively process cocaine-associated environmental cues in the rhesus monkey. 14 Sep 2009
• Attenuated behavioural responses to acute and chronic cocaine in GASP-1-deficient mice. 25 Aug 2009
• Isoflurane anesthesia interferes with the expression of cocaine-induced sensitization in female rats. 2 Aug 2009
• Environmental and pharmacological factors in the development of noncontingent tolerance to cocaine in pigeons. 30 Jul 2009
• Examination of reinforcement magnitude on the pharmacological disruption of fixed-ratio performance. 30 Jul 2009
• Repeated dosing with oral cocaine in humans: assessment of direct effects, withdrawal, and pharmacokinetics. 30 Jul 2009
• A phase 1 trial of pharmacologic interactions between transdermal selegiline and a 4-hour cocaine infusion. 30 Jul 2009
• Inactivating the activated: identifying functions of specific neural networks. 30 Jul 2009
• Acquisition of and withdrawal from cocaine self-administration regulates 5-HT mRNA expression in rat striatum. 28 Jul 2009
• Fluoxetine (Prozac) binding to serotonin transporter is modulated by chloride and conformational changes. 27 Jul 2009
• Orexin/hypocretin signaling at the orexin 1 receptor regulates cue-elicited cocaine-seeking. 26 Jul 2009
• Cyclin-dependent kinase 5 inhibitors: inhibition of dopamine transporter activity. 21 Jul 2009
• Targeted disruption of cocaine-activated nucleus accumbens neurons prevents context-specific sensitization. 18 Jul 2009
• In vivo cocaine experience generates silent synapses. 14 Jul 2009
• Antidepressant treatment facilitates dopamine release and drug seeking behavior in a genetic animal model of depression. 13 Jul 2009
• Cocaine-evoked synaptic plasticity: persistence in the VTA triggers adaptations in the NAc. 11 Jul 2009

See a longer list of these articles.

Technical information about 'Cocaine'

Definition: An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse. Cocaine, like amphetamines, acts by multiple mechanisms on brain catecholaminergic neurons; the mechanism of its reinforcing effects is thought to involve inhibition of dopamine uptake.

Chemical name: 8-Azabicyclo(3.2.1)octane-2-carboxylic acid, 3-(benzoyloxy)-8-methyl-, methyl ester, (1R-(exo,exo))-

Registry Number: 50-36-2

Descriptor UI: D003042

Alternative terms: Cocaine; Cocaine Hydrochloride; Hydrochloride, Cocaine; Cocaine HCl; HCl, Cocaine;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: Vasoconstrictor Agents; Dopamine Uptake Inhibitors; Anesthetics, Local;

Tree Number: D02.145.074.722.388; D03.132.889.354; D03.605.869.388; D04.075.080.875.099.722.388;

Online Note: use COCAINE/analogs & derivatives to search COCAINE DERIVATIVES 1975-77; use TROPANES 1969-74

History Note: COCAINE DERIVATIVES was see under COCAINE 1975-77; was see under TROPANES 1969-74

Technical Notes: cocaine derivatives = COCAINE /analogs;CRACK COCAINE is available; cocaine addiction = COCAINE-RELATED DISORDERS