Cocaine-Related Disorders - Genetics
Research News and Information

Monday, November 23, 2009

Lack of cocaine self-administration in mice expressing a cocaine-insensitive dopamine transporter.

12 Jul 2009 Cocaine addiction is a worldwide public health problem for which there are no established treatments. The dopamine transporter (DAT) is suspected as the primary target mediating cocaine's abuse-related effects based on numerous pharmacological ... Read more...

Measurement of the risk for substance use disorders: phenotypic and genetic analysis of an index of common liability.

16 Apr 2009 The inability to quantify the risk for disorders, such as substance use disorders (SUD), hinders etiology research and development of targeted intervention. Based on the concept of common transmissible liability to SUD related to illicit drugs, a ... Read more...

Neuropeptide S reinstates cocaine-seeking behavior and increases locomotor activity through corticotropin-releasing factor receptor 1 in mice.

30 Mar 2009 Neuropeptide S (NPS) is a recently discovered neuropeptide that increases arousal and wakefulness while decreasing anxiety-like behavior. Here, we used a self-administration paradigm to demonstrate that intracerebroventricular infusion of NPS ... Read more...

Latest indexed articles for 'Cocaine-Related Disorders - Genetics'

These are the very latest articles for this heading:

• Lack of cocaine self-administration in mice expressing a cocaine-insensitive dopamine transporter. 12 Jul 2009
• Measurement of the risk for substance use disorders: phenotypic and genetic analysis of an index of common liability. 16 Apr 2009
• Neuropeptide S reinstates cocaine-seeking behavior and increases locomotor activity through corticotropin-releasing factor receptor 1 in mice. 30 Mar 2009
• New insights into the genetics of addiction. 30 Mar 2009
• Genetic differences in hippocampal synaptic plasticity. 26 Mar 2009
• Association of variants in MANEA with cocaine-related behaviors. 27 Feb 2009
• Stress and addiction: glucocorticoid receptor in dopaminoceptive neurons facilitates cocaine seeking. 20 Feb 2009
• Association analysis between polymorphisms in the conserved dopamine neurotrophic factor (CDNF) gene and cocaine dependence. 19 Feb 2009
• Ethanol- and cocaine-induced locomotion are genetically related to increases in accumbal dopamine. 9 Feb 2009
• Perspective: the manifest destiny of cocaine research. 2 Feb 2009
• Short- and long-term adverse effects of cocaine abuse during pregnancy on the heart development. 30 Jan 2009
• Pharmacogenetic treatments for drug addiction: cocaine, amphetamine and methamphetamine. 30 Dec 2008
• Marker-assisted dissection of genetic influences on motor and neuroendocrine sensitization to cocaine in rats. 9 Dec 2008
• Interaction between two independent CNR1 variants increases risk for cocaine dependence in European Americans: a replication study in family-based sample and population-based sample. Dec 2008
• Loss of the Ca2+/calmodulin-dependent protein kinase type IV in dopaminoceptive neurons enhances behavioral effects of cocaine. 8 Nov 2008
• Neonatal FGF2 alters cocaine self-administration in the adult rat. 3 Nov 2008
• A functional haplotype implicated in vulnerability to develop cocaine dependence is associated with reduced PDYN expression in human brain. 13 Oct 2008
• Does COMT val158met affect behavioral phenotypes: yes, no, maybe? 13 Oct 2008
• Cortical thickness abnormalities in cocaine addiction--a reflection of both drug use and a pre-existing disposition to drug abuse? 7 Oct 2008
• Correlating human and animal studies of cocaine abuse and gene expression. 29 Sep 2008

See a longer list of these articles.

Technical information about 'Cocaine-Related Disorders'

Definition: Disorders related or resulting from use of cocaine.

Descriptor UI: D019970

Alternative terms: Cocaine-Related Disorders; Cocaine Related Disorders; Cocaine-Related Disorder; Disorder, Cocaine-Related; Disorders, Cocaine-Related; Cocaine Abuse; Abuse, Cocaine; Cocaine Dependence; Dependence, Cocaine; Dependences, Cocaine; Cocaine Addiction; Addiction, Cocaine;

Allowable Qualifiers: blood; cerebrospinal fluid; classification; complications; diagnosis; diet therapy; drug therapy; economics; enzymology; ethnology; etiology; genetics; history; immunology; metabolism; microbiology; mortality; nursing; epidemiology; parasitology; pathology; physiopathology; prevention & control; psychology; radiography; radionuclide imaging; rehabilitation; surgery; therapy; urine; ultrasonography; virology;

Tree Number: C21.739.300; F03.900.300;

History Note: 98