Cocaine-Related Disorders - Physiopathology
Research News and Information

Saturday, November 21, 2009

A neurocomputational model for cocaine addiction.

29 Sep 2009 Based on the dopamine hypotheses of cocaine addiction and the assumption of decrement of brain reward system sensitivity after long-term drug exposure, we propose a computational model for cocaine addiction. Utilizing average reward temporal ... Read more...

Neurotoxic and cardiotoxic effects of cocaine and ethanol.

30 Aug 2009 INTRODUCTION: Concurrent abuse of alcohol and cocaine results in the formation of cocaethylene, a powerful cocaine metabolite. Cocaethylene potentiates the direct cardiotoxic and indirect neurotoxic effects of cocaine or alcohol alone. CASE REPORT: ... Read more...

Orexin/hypocretin signaling at the orexin 1 receptor regulates cue-elicited cocaine-seeking.

26 Jul 2009 The orexin/hypocretin system has recently been implicated in reward-processing and addiction. We examined the involvement of the orexin system in cue-induced reinstatement of extinguished cocaine-seeking by administering the orexin 1 receptor ... Read more...

Latest indexed articles for 'Cocaine-Related Disorders - Physiopathology'

These are the very latest articles for this heading:

• A neurocomputational model for cocaine addiction. 29 Sep 2009
• Neurotoxic and cardiotoxic effects of cocaine and ethanol. 30 Aug 2009
• Inactivating the activated: identifying functions of specific neural networks. 30 Jul 2009
• Orexin/hypocretin signaling at the orexin 1 receptor regulates cue-elicited cocaine-seeking. 26 Jul 2009
• Upregulation of GLT1 attenuates cue-induced reinstatement of cocaine-seeking behavior in rats. 20 Jul 2009
• Targeted disruption of cocaine-activated nucleus accumbens neurons prevents context-specific sensitization. 18 Jul 2009
• Cocaine-evoked synaptic plasticity: persistence in the VTA triggers adaptations in the NAc. 11 Jul 2009
• The effect of olanzapine pretreatment on acute cocaine toxicity in mice. 29 Jun 2009
• Cocaine modulates locomotion behavior in C. elegans. 15 Jun 2009
• Anterior cingulate cortex hypoactivations to an emotionally salient task in cocaine addiction. 26 May 2009
• Prolonged withdrawal from repeated noncontingent cocaine exposure increases NMDA receptor expression and ERK activity in the nucleus accumbens. 25 May 2009
• Control of within-binge cocaine-seeking by dopamine and glutamate in the core of nucleus accumbens. 11 May 2009
• Cue-induced dopamine release predicts cocaine preference: positron emission tomography studies in freely moving rodents. 11 May 2009
• Signaling pathway adaptations and novel protein kinase A substrates related to behavioral sensitization to cocaine. May 2009
• Sex differences in sleep and sleep-dependent learning in abstinent cocaine users. 16 Apr 2009
• Differential involvement of the norepinephrine, serotonin and dopamine reuptake transporter proteins in cocaine-induced taste aversion. 15 Apr 2009
• Escalation of food-maintained responding and sensitivity to the locomotor stimulant effects of cocaine in mice. 15 Apr 2009
• Third pathophysiology of prenatal cocaine exposure. 15 Apr 2009
• Recent EEG and ERP findings in substance abusers. 30 Mar 2009
• Dissociable effects of cocaine-seeking behavior following D1 receptor activation and blockade within the caudal and rostral basolateral amygdala in rats. 30 Mar 2009

See a longer list of these articles.

Technical information about 'Cocaine-Related Disorders'

Definition: Disorders related or resulting from use of cocaine.

Descriptor UI: D019970

Alternative terms: Cocaine-Related Disorders; Cocaine Related Disorders; Cocaine-Related Disorder; Disorder, Cocaine-Related; Disorders, Cocaine-Related; Cocaine Abuse; Abuse, Cocaine; Cocaine Dependence; Dependence, Cocaine; Dependences, Cocaine; Cocaine Addiction; Addiction, Cocaine;

Allowable Qualifiers: blood; cerebrospinal fluid; classification; complications; diagnosis; diet therapy; drug therapy; economics; enzymology; ethnology; etiology; genetics; history; immunology; metabolism; microbiology; mortality; nursing; epidemiology; parasitology; pathology; physiopathology; prevention & control; psychology; radiography; radionuclide imaging; rehabilitation; surgery; therapy; urine; ultrasonography; virology;

Tree Number: C21.739.300; F03.900.300;

History Note: 98