Cocaine
Research News and Information

Saturday, November 21, 2009

Cocaine exposure in utero alters synaptic plasticity in the medial prefrontal cortex of postnatal rats.

5 Oct 2009 Cocaine exposure during pregnancy causes abnormality in fetal brain development, leading to cognitive dysfunction of the offspring, but the underlying cellular mechanism remains mostly unclear. In this study, we examined synaptic functions in the ... Read more...

Simultaneous screening and quantification of 29 drugs of abuse in oral fluid by solid-phase extraction and ultraperformance LC-MS/MS.

29 Sep 2009 BACKGROUND: The European DRUID (Driving under the Influence of Drugs, Alcohol And Medicines) project calls for analysis of oral fluid (OF) samples, collected randomly and anonymously at the roadside from drivers in Denmark throughout 2008-2009. To ... Read more...

A neurocomputational model for cocaine addiction.

29 Sep 2009 Based on the dopamine hypotheses of cocaine addiction and the assumption of decrement of brain reward system sensitivity after long-term drug exposure, we propose a computational model for cocaine addiction. Utilizing average reward temporal ... Read more...

Latest indexed articles for 'Cocaine'

These are the very latest articles for this heading:

• Cocaine exposure in utero alters synaptic plasticity in the medial prefrontal cortex of postnatal rats. 5 Oct 2009
• Simultaneous screening and quantification of 29 drugs of abuse in oral fluid by solid-phase extraction and ultraperformance LC-MS/MS. 29 Sep 2009
• A neurocomputational model for cocaine addiction. 29 Sep 2009
• Diffusion tensor imaging in cocaine dependence: regional effects of cocaine on corpus callosum and effect of cocaine administration route. 29 Sep 2009
• Regulation of dynamin 2 and G protein-coupled receptor kinase 2 in rat nucleus accumbens during acute and repeated cocaine administration. 29 Sep 2009
• c-Fos expression associated with reinstatement of cocaine-seeking behavior by response-contingent conditioned cues. 29 Sep 2009
• Similar neurons, opposite adaptations: psychostimulant experience differentially alters firing properties in accumbens core versus shell. 28 Sep 2009
• [Neuroenhancement: doping for the brain] 27 Sep 2009
• The 18F-FDG PET cingulate island sign and comparison to 123I-beta-CIT SPECT for diagnosis of dementia with Lewy bodies. 14 Sep 2009
• Orbitofrontal and anterior cingulate cortex neurons selectively process cocaine-associated environmental cues in the rhesus monkey. 14 Sep 2009
• [Cocaine-triggered ischaemic enteritis] 12 Sep 2009
• Oral fluid testing for drugs of abuse. 8 Sep 2009
• Evaluating dopamine reward pathway in ADHD: clinical implications. 7 Sep 2009
• Neural encoding of cocaine-seeking behavior is coincident with phasic dopamine release in the accumbens core and shell. 2 Sep 2009
• Psychological mood state of opiate addicted women during pregnancy and postpartum in comparison to non-addicted healthy women. 30 Aug 2009
• An unusual case of cocaine-induced maculopathy. 30 Aug 2009
• Neurotoxic and cardiotoxic effects of cocaine and ethanol. 30 Aug 2009
• Comprehensive analysis of drugs of abuse in urine using disposable pipette extraction. 30 Aug 2009
• Cocaine and opiates use in pregnancy: detection of drugs in neonatal meconium and urine. 30 Aug 2009
• Toxic and acquired metabolic encephalopathies: MRI appearance. 30 Aug 2009

See a longer list of these articles.

Technical information about 'Cocaine'

Definition: An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse. Cocaine, like amphetamines, acts by multiple mechanisms on brain catecholaminergic neurons; the mechanism of its reinforcing effects is thought to involve inhibition of dopamine uptake.

Chemical name: 8-Azabicyclo(3.2.1)octane-2-carboxylic acid, 3-(benzoyloxy)-8-methyl-, methyl ester, (1R-(exo,exo))-

Registry Number: 50-36-2

Descriptor UI: D003042

Alternative terms: Cocaine; Cocaine Hydrochloride; Hydrochloride, Cocaine; Cocaine HCl; HCl, Cocaine;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: Vasoconstrictor Agents; Dopamine Uptake Inhibitors; Anesthetics, Local;

Tree Number: D02.145.074.722.388; D03.132.889.354; D03.605.869.388; D04.075.080.875.099.722.388;

Online Note: use COCAINE/analogs & derivatives to search COCAINE DERIVATIVES 1975-77; use TROPANES 1969-74

History Note: COCAINE DERIVATIVES was see under COCAINE 1975-77; was see under TROPANES 1969-74

Technical Notes: cocaine derivatives = COCAINE /analogs;CRACK COCAINE is available; cocaine addiction = COCAINE-RELATED DISORDERS