Collagen Type I - Biosynthesis
Research News and Information

Saturday, November 21, 2009

Rac1 promotes TGF-beta-stimulated mesangial cell type I collagen expression through a PI3K/Akt-dependent mechanism.

31 Aug 2009 Transforming growth factor (TGF)-beta is a central mediator in the progression of glomerulosclerosis, leading to accumulation of aberrant extracellular matrix proteins and inappropriate expression of smooth muscle alpha-actin in the kidney. ... Read more...

Composite chitosan/nano-hydroxyapatite scaffolds induce osteocalcin production by osteoblasts in vitro and support bone formation in vivo.

30 Aug 2009 There is a significant clinical need to develop alternatives to autografts and allografts for bone grafting procedures. Porous, biodegradable scaffolds based on the biopolymer chitosan have been investigated as bone graft substitutes, and the ... Read more...

Less Smad2 is good for you! A scientific update on coffee's liver benefits.

30 Aug 2009 Scientists at the National Institutes of Health have reported that increased coffee consumption is associated with a slower progression of fibrogenesis in patients with chronic and particularly alcoholic liver disease and a reduced incidence of ... Read more...

Latest indexed articles for 'Collagen Type I - Biosynthesis'

These are the very latest articles for this heading:

• Rac1 promotes TGF-beta-stimulated mesangial cell type I collagen expression through a PI3K/Akt-dependent mechanism. 31 Aug 2009
• Composite chitosan/nano-hydroxyapatite scaffolds induce osteocalcin production by osteoblasts in vitro and support bone formation in vivo. 30 Aug 2009
• Less Smad2 is good for you! A scientific update on coffee's liver benefits. 30 Aug 2009
• Chronic angiotensin-(1-7) administration improves vascular remodeling after angioplasty through the regulation of the TGF-beta/Smad signaling pathway in rabbits. 24 Aug 2009
• Osteogenic potential and responsiveness to leptin of mesenchymal stem cells between postmenopausal women with osteoarthritis and osteoporosis. 30 Jul 2009
• Insulin-like growth factor-I improves chondrogenesis of predifferentiated human umbilical cord mesenchymal stromal cells. 30 Jul 2009
• Temporal growth factor release from platelet-rich plasma, trehalose lyophilized platelets, and bone marrow aspirate and their effect on tendon and ligament gene expression. 30 Jul 2009
• Cannabinoids inhibit fibrogenesis in diffuse systemic sclerosis fibroblasts. 7 Jul 2009
• Type I pro-collagen promoting and anti-collagenase activities of Phyllanthus emblica extract in mouse fibroblasts. 29 Jun 2009
• Hepatic stellate cells express functional CXCR4: role in stromal cell-derived factor-1alpha-mediated stellate cell activation. 30 May 2009
• The linker region of Smad2 mediates TGF-beta-dependent ERK2-induced collagen synthesis. 20 May 2009
• Pleural mesothelial cell transformation into myofibroblasts and haptotactic migration in response to TGF-beta1 in vitro. 29 Apr 2009
• Periostin promotes a fibroblastic lineage pathway in atrioventricular valve progenitor cells. 29 Apr 2009
• Histone deacetylase 7, a potential target for the antifibrotic treatment of systemic sclerosis. 29 Apr 2009
• Response of human osteoblasts exposed to wear particles generated at the interface of total hip stems and bone cement. 29 Apr 2009
• Low-level laser irradiation promotes cell proliferation and mRNA expression of type I collagen and decorin in porcine Achilles tendon fibroblasts in vitro. 29 Apr 2009
• Chondrogenic differentiation of adipose tissue-derived mesenchymal stem cells: greater doses of growth factor are necessary. 29 Apr 2009
• Differential long-term stimulation of type I versus type III collagen after infrared irradiation. 26 Apr 2009
• Pancreatic carcinoma cells stimulate proliferation and matrix synthesis of hepatic stellate cells. 20 Apr 2009
• Zinc supplementation attenuates ethanol- and acetaldehyde-induced liver stellate cell activation by inhibiting reactive oxygen species (ROS) production and by influencing intracellular signaling. 15 Apr 2009

See a longer list of these articles.

Technical information about 'Collagen Type I'

Definition: The most common form of fibrillar collagen. It is a major constituent of bone (BONE AND BONES) and SKIN and consists of a heterotrimer of two alpha1(I) and one alpha2(I) chains.

Registry Number: 0

Descriptor UI: D024042

Alternative terms: Collagen Type I; Type 1 Collagen; Collagen, Type 1; Type I Collagen; Collagen, Type I; Procollagen Type I; Type I Procollagen; Procollagen, Type I; Pro alpha 1 Collagen; Pro alpha 2 Collagen; Collagen Type I, alpha1 Subunit; alpha1 Type 1 Collagen; Collagen Type I, alpha1 Chain; Collagen alpha1(I); Collagen Type I, alpha2 Subunit; Collagen alpha2(I); alpha2 Type 1 Collagen; Collagen Type I, alpha2 Chain; alpha-2 Type 1 Collagen;

Related Mesh Headings: Osteogenesis Imperfecta;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists;

Tree Number: D05.750.078.280.300.100; D12.776.860.300.250.300.100;

History Note: 2002; use COLLAGEN 1966-2001; for ALPHA-2 TYPE 1 COLLAGEN use COLLAGEN 1987-2001; for PROCOLLAGEN TYPE I use PROCOLLAGEN 1986-2001; for TYPE I PROCOLLAGEN & PRO ALPHA 2 COLLAGEN use PROCOLLAGEN 1982-2001; for PRO ALPHA 1 COLLAGEN use PROCOLLAGEN 1988-2001

Technical Notes: precursors: coord IM with PROCOLLAGEN (IM)