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Collagen Type I
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Definition of 'Collagen Type I'

The most common form of fibrillar collagen. It is a major constituent of bone (BONE AND BONES) and SKIN and consists of a heterotrimer of two alpha1(I) and one alpha2(I) chains.

Common names: Collagen Type I; Type 1 Collagen; Collagen, Type 1; Type I Collagen; Collagen, Type I; Procollagen Type I; Type I Procollagen; Procollagen, Type I; Pro alpha 1 Collagen; Pro alpha 2 Collagen; Collagen Type I, alpha1 Subunit; alpha1 Type 1 Collagen; Collagen Type I, alpha1 Chain; Collagen alpha1(I)

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Saturday, November 21, 2009

Runx2, p53, and pRB status as diagnostic parameters for deregulation of osteoblast growth and differentiation in a new pre-chemotherapeutic osteosarcoma cell line (OS1).

29 Nov 2009 Osteosarcomas are the most prevalent primary bone tumors found in pediatric patients. To understand their molecular etiology, cell culture models are used to define disease mechanisms under controlled conditions. Many osteosarcoma cell lines (e.g., ... Read more...


OPLA scaffold, collagen I, and horse serum induce an higher degree of myogenic differentiation of adult rat cardiac stem cells.

29 Nov 2009 In the last few years, a major goal of cardiac research has been to drive stem cell differentiation to replace damaged myocardium. Several research groups have attempted to differentiate potential cardiac stem cells (CSCs) using bi- or ... Read more...


Natural history of markers of collagen turnover in patients with early diastolic dysfunction and impact of eplerenone.

25 Oct 2009 OBJECTIVES: This study was designed to evaluate the impact of eplerenone on collagen turnover in preserved systolic function heart failure (HFPSF). BACKGROUND: Despite growing interest in abnormal collagen metabolism as a feature of HFPSF with ... Read more...

 

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Technical information about 'Collagen Type I'

Definition: The most common form of fibrillar collagen. It is a major constituent of bone (BONE AND BONES) and SKIN and consists of a heterotrimer of two alpha1(I) and one alpha2(I) chains.

Registry Number: 0

Descriptor UI: D024042

Alternative terms: Collagen Type I; Type 1 Collagen; Collagen, Type 1; Type I Collagen; Collagen, Type I; Procollagen Type I; Type I Procollagen; Procollagen, Type I; Pro alpha 1 Collagen; Pro alpha 2 Collagen; Collagen Type I, alpha1 Subunit; alpha1 Type 1 Collagen; Collagen Type I, alpha1 Chain; Collagen alpha1(I); Collagen Type I, alpha2 Subunit; Collagen alpha2(I); alpha2 Type 1 Collagen; Collagen Type I, alpha2 Chain; alpha-2 Type 1 Collagen;

Related Mesh Headings: Osteogenesis Imperfecta;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists;

Tree Number: D05.750.078.280.300.100; D12.776.860.300.250.300.100;

History Note: 2002; use COLLAGEN 1966-2001; for ALPHA-2 TYPE 1 COLLAGEN use COLLAGEN 1987-2001; for PROCOLLAGEN TYPE I use PROCOLLAGEN 1986-2001; for TYPE I PROCOLLAGEN & PRO ALPHA 2 COLLAGEN use PROCOLLAGEN 1982-2001; for PRO ALPHA 1 COLLAGEN use PROCOLLAGEN 1988-2001

Technical Notes: precursors: coord IM with PROCOLLAGEN (IM)

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